Human Gene PDZD11 (uc004dyd.1) Description and Page Index
  Description: Homo sapiens PDZ domain containing 11 (PDZD11), mRNA.
Transcript (Including UTRs)
   Position: hg19 chrX:69,506,211-69,509,798 Size: 3,588 Total Exon Count: 7 Strand: -
Coding Region
   Position: hg19 chrX:69,506,932-69,509,191 Size: 2,260 Coding Exon Count: 6 

Page IndexSequence and LinksUniProtKB CommentsMalaCardsCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated: 2013-06-14

-  Sequence and Links to Tools and Databases
Genomic Sequence (chrX:69,506,211-69,509,798)mRNA (may differ from genome)Protein (140 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
BioGPSCGAPEnsemblEntrez GeneExonPrimerGeneCards
neXtProtOMIMPubMedReactomeStanford SOURCETreefam

-  Comments and Description Text from UniProtKB
DESCRIPTION: RecName: Full=PDZ domain-containing protein 11;
SUBCELLULAR LOCATION: Isoform 2: Secreted (Potential).
SIMILARITY: Contains 1 PDZ (DHR) domain.

-  MalaCards Disease Associations
  MalaCards Gene Search: PDZD11
Diseases sorted by gene-association score: purulent acute otitis media (8), pleomorphic adenoma carcinoma (2), middle ear disease (2)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 32.59 RPKM in Brain - Hypothalamus
Total median expression: 884.40 RPKM

View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -36.00102-0.353 Picture PostScript Text
3' UTR -197.62721-0.274 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR001478 - PDZ

Pfam Domains:
PF00595 - PDZ domain (Also known as DHR or GLGF)
PF13180 - PDZ domain

SCOP Domains:
50156 - PDZ domain-like

ModBase Predicted Comparative 3D Structure on Q5EBL8
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005515 protein binding
GO:0008022 protein C-terminus binding

Biological Process:
GO:0007269 neurotransmitter secretion
GO:0045199 maintenance of epithelial cell apical/basal polarity
GO:1903361 protein localization to basolateral plasma membrane

Cellular Component:
GO:0005576 extracellular region
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005911 cell-cell junction
GO:0016323 basolateral plasma membrane
GO:0045202 synapse
GO:0098793 presynapse

-  Descriptions from all associated GenBank mRNAs
  BX537725 - Homo sapiens mRNA; cDNA DKFZp686O17275 (from clone DKFZp686O17275); complete cds.
LF211591 - JP 2014500723-A/19094: Polycomb-Associated Non-Coding RNAs.
LF385341 - JP 2014500723-A/192844: Polycomb-Associated Non-Coding RNAs.
AK311539 - Homo sapiens cDNA, FLJ18581.
BC089433 - Homo sapiens PDZ domain containing 11, mRNA (cDNA clone IMAGE:30559280), partial cds.
BC012996 - Homo sapiens PDZ domain containing 11, mRNA (cDNA clone MGC:3404 IMAGE:3530647), complete cds.
AK024746 - Homo sapiens cDNA: FLJ21093 fis, clone CAS03791, highly similar to AF151061 Homo sapiens HSPC227 mRNA.
AF151061 - Homo sapiens HSPC227 mRNA, complete cds.
AY358829 - Homo sapiens clone DNA143010 GWSC6486 (UNQ6486) mRNA, complete cds.
JD398459 - Sequence 379483 from Patent EP1572962.
JD365800 - Sequence 346824 from Patent EP1572962.
LF381700 - JP 2014500723-A/189203: Polycomb-Associated Non-Coding RNAs.
LF381701 - JP 2014500723-A/189204: Polycomb-Associated Non-Coding RNAs.
JD113082 - Sequence 94106 from Patent EP1572962.
JD349502 - Sequence 330526 from Patent EP1572962.
JD424869 - Sequence 405893 from Patent EP1572962.
JD428731 - Sequence 409755 from Patent EP1572962.
LF381702 - JP 2014500723-A/189205: Polycomb-Associated Non-Coding RNAs.
JD502153 - Sequence 483177 from Patent EP1572962.
KJ898866 - Synthetic construct Homo sapiens clone ccsbBroadEn_08260 PDZD11 gene, encodes complete protein.
AB464005 - Synthetic construct DNA, clone: pF1KB8215, Homo sapiens PDZD11 gene for PDZ domain containing 11, without stop codon, in Flexi system.
AM393208 - Synthetic construct Homo sapiens clone IMAGE:100002275 for hypothetical protein (PDZD11 gene).
CR457149 - Homo sapiens full open reading frame cDNA clone RZPDo834C129D for gene LOC51248, hypothetical protein LOC51248; complete cds, incl. stopcodon.
LF381703 - JP 2014500723-A/189206: Polycomb-Associated Non-Coding RNAs.
JD532540 - Sequence 513564 from Patent EP1572962.
JD220960 - Sequence 201984 from Patent EP1572962.
MA620918 - JP 2018138019-A/192844: Polycomb-Associated Non-Coding RNAs.
MA447168 - JP 2018138019-A/19094: Polycomb-Associated Non-Coding RNAs.
MA617277 - JP 2018138019-A/189203: Polycomb-Associated Non-Coding RNAs.
MA617278 - JP 2018138019-A/189204: Polycomb-Associated Non-Coding RNAs.
MA617279 - JP 2018138019-A/189205: Polycomb-Associated Non-Coding RNAs.
MA617280 - JP 2018138019-A/189206: Polycomb-Associated Non-Coding RNAs.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein Q5EBL8 (Reactome details) participates in the following event(s):

R-HSA-936802 ATP7A transports cytosolic Cu2+ to extracellular region
R-HSA-199206 SLC5A6 cotransports extracellular PanK and 2Na+ to cytosol
R-HSA-199219 SLC5A6 cotransports extracellular Btn and 2xNa+ to cytosol
R-HSA-429581 SLC5A6 transports vitamins from extracellular region to cytosol
R-HSA-6803545 ATP7A transports cytosolic Cu2+ to phagosomal lumen
R-HSA-936837 Ion transport by P-type ATPases
R-HSA-199220 Vitamin B5 (pantothenate) metabolism
R-HSA-196780 Biotin transport and metabolism
R-HSA-425397 Transport of vitamins, nucleosides, and related molecules
R-HSA-6803544 Ion influx/efflux at host-pathogen interface
R-HSA-983712 Ion channel transport
R-HSA-196849 Metabolism of water-soluble vitamins and cofactors
R-HSA-425407 SLC-mediated transmembrane transport
R-HSA-6803157 Antimicrobial peptides
R-HSA-382551 Transport of small molecules
R-HSA-196854 Metabolism of vitamins and cofactors
R-HSA-168249 Innate Immune System
R-HSA-1430728 Metabolism
R-HSA-168256 Immune System

-  Other Names for This Gene
  Alternate Gene Symbols: D3DVU3, HSPC227, NM_016484, NP_057568, PDZ11_HUMAN, PDZK11, Q5EBL8, Q6UWE1, Q9P0Q1, UNQ6486/PRO21335
UCSC ID: uc004dyd.1
RefSeq Accession: NM_016484
Protein: Q5EBL8 (aka PDZ11_HUMAN)
CCDS: CCDS14400.1

-  Gene Model Information
category: coding nonsense-mediated-decay: no RNA accession: NM_016484.4
exon count: 7CDS single in 3' UTR: no RNA size: 1246
ORF size: 423CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 802.00frame shift in genome: no % Coverage: 100.00
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.