Human Gene EMC2 (uc003ymw.1) Description and Page Index
  Description: Homo sapiens ER membrane protein complex subunit 2 (EMC2), mRNA.
Transcript (Including UTRs)
   Position: hg19 chr8:109,455,853-109,499,136 Size: 43,284 Total Exon Count: 11 Strand: +
Coding Region
   Position: hg19 chr8:109,455,888-109,498,827 Size: 42,940 Coding Exon Count: 11 

Page IndexSequence and LinksUniProtKB CommentsCTDGene AllelesRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
Other NamesModel InformationMethods
Data last updated: 2013-06-14

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr8:109,455,853-109,499,136)mRNA (may differ from genome)Protein (297 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
BioGPSCGAPEnsemblEntrez GeneExonPrimerGeneCards
neXtProtOMIMPubMedStanford SOURCETreefamUniProtKB

-  Comments and Description Text from UniProtKB
DESCRIPTION: RecName: Full=ER membrane protein complex subunit 2; AltName: Full=Tetratricopeptide repeat protein 35; Short=TPR repeat protein 35;
SUBUNIT: Component of the ER membrane protein complex (EMC).
SUBCELLULAR LOCATION: Nucleus (By similarity). Cytoplasm.
SIMILARITY: Belongs to the EMC2 family.
SIMILARITY: Contains 3 TPR repeats.

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
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-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 37.28 RPKM in Brain - Spinal cord (cervical c-1)
Total median expression: 1098.12 RPKM

View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -9.7035-0.277 Picture PostScript Text
3' UTR -54.41309-0.176 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR001440 - TPR-1
IPR013026 - TPR-contain_dom
IPR011990 - TPR-like_helical
IPR013105 - TPR_2
IPR019734 - TPR_repeat

Pfam Domains:
PF13181 - Tetratricopeptide repeat
PF14559 - Tetratricopeptide repeat

SCOP Domains:
81901 - HCP-like
48439 - Protein prenylyltransferase
48452 - TPR-like

ModBase Predicted Comparative 3D Structure on Q15006
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologGenome BrowserGenome BrowserGenome BrowserGenome BrowserGenome Browser
Gene DetailsGene Details Gene DetailsGene DetailsGene Details
Gene SorterGene Sorter Gene SorterGene SorterGene Sorter
 Protein SequenceProtein SequenceProtein SequenceProtein SequenceProtein Sequence

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005515 protein binding

Biological Process:
GO:0034975 protein folding in endoplasmic reticulum

Cellular Component:
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005783 endoplasmic reticulum
GO:0072546 ER membrane protein complex

-  Descriptions from all associated GenBank mRNAs
  BC021667 - Homo sapiens tetratricopeptide repeat domain 35, mRNA (cDNA clone MGC:22689 IMAGE:3682913), complete cds.
LP895594 - Sequence 458 from Patent EP3253886.
JD365713 - Sequence 346737 from Patent EP1572962.
AK222615 - Homo sapiens mRNA for KIAA0103 variant, clone: CBL00683.
BC020753 - Homo sapiens tetratricopeptide repeat domain 35, mRNA (cDNA clone MGC:22600 IMAGE:4809693), complete cds.
BC007027 - Homo sapiens tetratricopeptide repeat domain 35, mRNA (cDNA clone IMAGE:4051121), containing frame-shift errors.
AK290974 - Homo sapiens cDNA FLJ76169 complete cds.
D14659 - Homo sapiens KIAA0103 mRNA, complete cds.
CU692380 - Synthetic construct Homo sapiens gateway clone IMAGE:100016996 5' read TTC35 mRNA.
AB384437 - Synthetic construct DNA, clone: pF1KA0103, Homo sapiens TTC35 gene for tetratricopeptide repeat protein 35, complete cds, without stop codon, in Flexi system.
CU676696 - Synthetic construct Homo sapiens gateway clone IMAGE:100022244 5' read TTC35 mRNA.
HQ447150 - Synthetic construct Homo sapiens clone IMAGE:100070438; CCSB007426_02 tetratricopeptide repeat domain 35 (TTC35) gene, encodes complete protein.
KJ892834 - Synthetic construct Homo sapiens clone ccsbBroadEn_02228 TTC35 gene, encodes complete protein.
KJ898074 - Synthetic construct Homo sapiens clone ccsbBroadEn_07468 TTC35 gene, encodes complete protein.
CR457402 - Homo sapiens full open reading frame cDNA clone RZPDo834B0818D for gene KIAA0103, KIAA0103; complete cds, incl. stopcodon.
AK057571 - Homo sapiens cDNA FLJ33009 fis, clone THYMU1000331, weakly similar to O-linked GlcNAc transferases.
JD326211 - Sequence 307235 from Patent EP1572962.
JD463634 - Sequence 444658 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: EMC2_HUMAN, KIAA0103, NM_014673, NP_055488, Q15006, Q8WUE1, TTC35
UCSC ID: uc003ymw.1
RefSeq Accession: NM_014673
Protein: Q15006 (aka EMC2_HUMAN)
CCDS: CCDS6309.1

-  Gene Model Information
category: coding nonsense-mediated-decay: no RNA accession: NM_014673.3
exon count: 11CDS single in 3' UTR: no RNA size: 1268
ORF size: 894CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 1988.00frame shift in genome: no % Coverage: 97.63
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.