Human Gene POP7 (uc003uwh.4) Description and Page Index
  Description: Homo sapiens processing of precursor 7, ribonuclease P/MRP subunit (S. cerevisiae) (POP7), mRNA.
Transcript (Including UTRs)
   Position: hg19 chr7:100,303,676-100,305,123 Size: 1,448 Total Exon Count: 2 Strand: +
Coding Region
   Position: hg19 chr7:100,304,454-100,304,876 Size: 423 Coding Exon Count: 1 

Page IndexSequence and LinksUniProtKB CommentsCTDGene AllelesRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
PathwaysOther NamesModel InformationMethods
Data last updated: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr7:100,303,676-100,305,123)mRNA (may differ from genome)Protein (140 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
BioGPSCGAPEnsemblEntrez GeneExonPrimerGeneCards
GeneNetworkH-INVHGNCHPRDLynxMGI
neXtProtOMIMPubMedReactomeStanford SOURCETreefam
UniProtKBWikipedia

-  Comments and Description Text from UniProtKB
  ID: POP7_HUMAN
DESCRIPTION: RecName: Full=Ribonuclease P protein subunit p20; Short=RNaseP protein p20; EC=3.1.26.5; AltName: Full=Ribonucleases P/MRP protein subunit POP7 homolog; Short=hPOP7;
FUNCTION: Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.
CATALYTIC ACTIVITY: Endonucleolytic cleavage of RNA, removing 5'- extranucleotides from tRNA precursor.
SUBUNIT: Component of nuclear RNase P and RNase MRP ribonucleoproteins. RNase P consists of a RNA moiety and at least 8 protein subunits; POP1, RPP14, RPP20/POP7, RPP25, RPP29/POP4, RPP30, RPP38 and RPP40. RNase MRP consists of a RNA moiety and at least 9 protein subunits; POP1, RPP14, RPP20/POP7, RPP25, RPP29/POP4, RPP30, RPP38, RPP40, POP5 and RPP21. Interacts with RPP25. RPP20/POP7 is probably a dimer.
INTERACTION: Q9BUL9:RPP25; NbExp=2; IntAct=EBI-366574, EBI-366570; P63162:SNRPN; NbExp=5; IntAct=EBI-366574, EBI-712493;
SUBCELLULAR LOCATION: Nucleus, nucleolus (Potential).
SIMILARITY: Belongs to the histone-like Alba family.

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
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-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 30.26 RPKM in Brain - Frontal Cortex (BA9)
Total median expression: 923.61 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -117.80262-0.450 Picture PostScript Text
3' UTR -76.54247-0.310 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR014612 - RNase_P/MRP_p20

Pfam Domains:
PF01918 - Alba
PF12328 - Rpp20 subunit of nuclear RNase MRP and P

SCOP Domains:
82704 - AlbA-like

ModBase Predicted Comparative 3D Structure on O75817
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
      
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0003676 nucleic acid binding
GO:0003723 RNA binding
GO:0004526 ribonuclease P activity
GO:0005515 protein binding
GO:0016787 hydrolase activity

Biological Process:
GO:0001682 tRNA 5'-leader removal
GO:0008033 tRNA processing
GO:0090502 RNA phosphodiester bond hydrolysis, endonucleolytic

Cellular Component:
GO:0000172 ribonuclease MRP complex
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005655 nucleolar ribonuclease P complex
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0030681 multimeric ribonuclease P complex


-  Descriptions from all associated GenBank mRNAs
  BC001430 - Homo sapiens processing of precursor 7, ribonuclease P/MRP subunit (S. cerevisiae), mRNA (cDNA clone MGC:1986 IMAGE:3138336), complete cds.
U94316 - Homo sapiens ribonuclease P protein subunit p20 (RPP20) mRNA, complete cds.
JD393738 - Sequence 374762 from Patent EP1572962.
JD473417 - Sequence 454441 from Patent EP1572962.
KJ892977 - Synthetic construct Homo sapiens clone ccsbBroadEn_02371 POP7 gene, encodes complete protein.
JD516687 - Sequence 497711 from Patent EP1572962.
JD203387 - Sequence 184411 from Patent EP1572962.
JD399294 - Sequence 380318 from Patent EP1572962.
JD424792 - Sequence 405816 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein O75817 (Reactome details) participates in the following event(s):

R-HSA-5696810 RNase P cleaves the 5' end of pre-tRNA
R-HSA-6784531 tRNA processing in the nucleus
R-HSA-72306 tRNA processing
R-HSA-8953854 Metabolism of RNA

-  Other Names for This Gene
  Alternate Gene Symbols: A4D2E0, NM_005837, NP_005828, O75817, POP7_HUMAN, Q9BV74, RPP20
UCSC ID: uc003uwh.4
RefSeq Accession: NM_005837
Protein: O75817 (aka POP7_HUMAN)
CCDS: CCDS5704.1

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: NM_005837.2
exon count: 2CDS single in 3' UTR: no RNA size: 949
ORF size: 423CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 1046.00frame shift in genome: no % Coverage: 98.21
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.