Human Gene MED10 (uc003jdo.3) Description and Page Index
Description: Homo sapiens mediator complex subunit 10 (MED10), mRNA. RefSeq Summary (NM_032286): MED10 is a component of the Mediator complex, which is a coactivator for DNA-binding factors that activate transcription via RNA polymerase II (Sato et al., 2003 [PubMed 12584197]).[supplied by OMIM, Oct 2008]. ##Evidence-Data-START## Transcript exon combination :: CB149061.1, SRR5189652.30109.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2467146 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000255764.4/ ENSP00000255764.3 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Transcript (Including UTRs) Position: hg19 chr5:6,372,039-6,378,639 Size: 6,601 Total Exon Count: 4 Strand: - Coding Region Position: hg19 chr5:6,372,616-6,378,596 Size: 5,981 Coding Exon Count: 4
ID:MED10_HUMAN DESCRIPTION: RecName: Full=Mediator of RNA polymerase II transcription subunit 10; AltName: Full=Mediator complex subunit 10; AltName: Full=Transformation-related gene 17 protein; Short=TRG-17; AltName: Full=Transformation-related gene 20 protein; Short=TRG-20; FUNCTION: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. SUBUNIT: Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP. SUBCELLULAR LOCATION: Nucleus (Probable). SIMILARITY: Belongs to the Mediator complex subunit 10 family.
Genetic Association Studies of Complex Diseases and Disorders
Genetic Association Database (archive): MED10 CDC HuGE Published Literature: MED10 Positive Disease Associations: Iron Related Studies:
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9BTT4
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0001104 RNA polymerase II transcription cofactor activity GO:0005515 protein binding GO:0061630 ubiquitin protein ligase activity
Biological Process: GO:0006351 transcription, DNA-templated GO:0006355 regulation of transcription, DNA-templated GO:0006357 regulation of transcription from RNA polymerase II promoter GO:0006367 transcription initiation from RNA polymerase II promoter GO:0016567 protein ubiquitination GO:0019827 stem cell population maintenance GO:0045944 positive regulation of transcription from RNA polymerase II promoter