Human Gene PSME3 (uc002ibq.4) Description and Page Index
  Description: Homo sapiens proteasome (prosome, macropain) activator subunit 3 (PA28 gamma; Ki) (PSME3), transcript variant 2, mRNA.
RefSeq Summary (NM_176863): The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. The immunoproteasome contains an alternate regulator, referred to as the 11S regulator or PA28, that replaces the 19S regulator. Three subunits (alpha, beta and gamma) of the 11S regulator have been identified. This gene encodes the gamma subunit of the 11S regulator. Six gamma subunits combine to form a homohexameric ring. Alternate splicing results in multiple transcript variants. [provided by RefSeq, May 2012].
Transcript (Including UTRs)
   Position: hg19 chr17:40,985,159-40,995,777 Size: 10,619 Total Exon Count: 11 Strand: +
Coding Region
   Position: hg19 chr17:40,985,649-40,993,595 Size: 7,947 Coding Exon Count: 11 

Page IndexSequence and LinksCTDGene AllelesRNA-Seq ExpressionMicroarray Expression
RNA StructureProtein StructureOther SpeciesmRNA DescriptionsPathwaysOther Names
Model InformationMethods
Data last updated: 2013-06-14

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr17:40,985,159-40,995,777)mRNA (may differ from genome)Protein (267 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaBioGPS
CGAPEnsemblEntrez GeneExonPrimerGeneCardsH-INV
ReactomeStanford SOURCEUniProtKBWikipedia

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 32.95 RPKM in Cells - EBV-transformed lymphocytes
Total median expression: 798.52 RPKM

View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -215.60490-0.440 Picture PostScript Text
3' UTR -689.272182-0.316 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  Pfam Domains:
PF02251 - Proteasome activator pa28 alpha subunit
PF02252 - Proteasome activator pa28 beta subunit

SCOP Domains:
47216 - Proteasome activator reg(alpha)

ModBase Predicted Comparative 3D Structure on P61289-2
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 Protein Sequence    

-  Descriptions from all associated GenBank mRNAs
  AK057221 - Homo sapiens cDNA FLJ32659 fis, clone TESTI1000045, highly similar to Proteasome activator complex subunit 3.
LF209350 - JP 2014500723-A/16853: Polycomb-Associated Non-Coding RNAs.
AK314347 - Homo sapiens cDNA, FLJ95110.
AK307110 - Homo sapiens cDNA, FLJ97058.
BC001423 - Homo sapiens proteasome (prosome, macropain) activator subunit 3 (PA28 gamma; Ki), mRNA (cDNA clone MGC:1394 IMAGE:3139753), complete cds.
EU794653 - Homo sapiens epididymis secretory protein Li 283 (HEL-S-283) mRNA, complete cds.
BX640801 - Homo sapiens mRNA; cDNA DKFZp686J2076 (from clone DKFZp686J2076).
AK292618 - Homo sapiens cDNA FLJ78054 complete cds, highly similar to Homo sapiens proteasome (prosome, macropain) activator subunit 3 (PA28 gamma; Ki) (PSME3), transcript variant 1, mRNA.
BC002684 - Homo sapiens proteasome (prosome, macropain) activator subunit 3 (PA28 gamma; Ki), mRNA (cDNA clone MGC:3572 IMAGE:3606558), complete cds.
JD067261 - Sequence 48285 from Patent EP1572962.
AK303211 - Homo sapiens cDNA FLJ57249 complete cds, highly similar to Proteasome activator complex subunit 3.
AK074999 - Homo sapiens cDNA FLJ90518 fis, clone NT2RP3004557, highly similar to Proteasome activator complex subunit 3.
LF327916 - JP 2014500723-A/135419: Polycomb-Associated Non-Coding RNAs.
JD195732 - Sequence 176756 from Patent EP1572962.
U11292 - Homo sapiens Ki nuclear autoantigen mRNA, complete cds.
JD462229 - Sequence 443253 from Patent EP1572962.
JD057644 - Sequence 38668 from Patent EP1572962.
BC008020 - Homo sapiens proteasome (prosome, macropain) activator subunit 3 (PA28 gamma; Ki), mRNA (cDNA clone MGC:15945 IMAGE:3537911), complete cds.
JD445538 - Sequence 426562 from Patent EP1572962.
JD343272 - Sequence 324296 from Patent EP1572962.
JD519415 - Sequence 500439 from Patent EP1572962.
AB528620 - Synthetic construct DNA, clone: pF1KB6359, Homo sapiens PSME3 gene for proteasome (prosome, macropain) activator subunit 3, without stop codon, in Flexi system.
DQ891930 - Synthetic construct clone IMAGE:100004560; FLH181520.01X; RZPDo839E04136D proteasome (prosome, macropain) activator subunit 3 (PA28 gamma; Ki) (PSME3) gene, encodes complete protein.
DQ895117 - Synthetic construct Homo sapiens clone IMAGE:100009577; FLH181516.01L; RZPDo839E04135D proteasome (prosome, macropain) activator subunit 3 (PA28 gamma; Ki) (PSME3) gene, encodes complete protein.
CU678118 - Synthetic construct Homo sapiens gateway clone IMAGE:100018614 5' read PSME3 mRNA.
KJ892954 - Synthetic construct Homo sapiens clone ccsbBroadEn_02348 PSME3 gene, encodes complete protein.
BT019386 - Homo sapiens proteasome (prosome, macropain) activator subunit 3 (PA28 gamma; Ki) mRNA, complete cds.
CR541745 - Homo sapiens full open reading frame cDNA clone RZPDo834H0629D for gene PSME3, proteasome (prosome, macropain) activator subunit 3 (PA28 gamma; Ki); complete cds, incl. stopcodon.
FJ200488 - Homo sapiens REG gamma-3 variant mRNA, complete cds.
JX156303 - Homo sapiens PA28 gamma variant 5 mRNA, complete cds, alternatively spliced.
JD160410 - Sequence 141434 from Patent EP1572962.
JD552520 - Sequence 533544 from Patent EP1572962.
JD087410 - Sequence 68434 from Patent EP1572962.
JD524256 - Sequence 505280 from Patent EP1572962.
JD297979 - Sequence 279003 from Patent EP1572962.
JD083813 - Sequence 64837 from Patent EP1572962.
JD551245 - Sequence 532269 from Patent EP1572962.
JD358351 - Sequence 339375 from Patent EP1572962.
JD290068 - Sequence 271092 from Patent EP1572962.
JD390715 - Sequence 371739 from Patent EP1572962.
JD418466 - Sequence 399490 from Patent EP1572962.
JD203496 - Sequence 184520 from Patent EP1572962.
JD404437 - Sequence 385461 from Patent EP1572962.
JD163923 - Sequence 144947 from Patent EP1572962.
JD555658 - Sequence 536682 from Patent EP1572962.
JD092648 - Sequence 73672 from Patent EP1572962.
JD252024 - Sequence 233048 from Patent EP1572962.
JD449057 - Sequence 430081 from Patent EP1572962.
JD020816 - Sequence 1840 from Patent EP1572962.
JD032767 - Sequence 13791 from Patent EP1572962.
JD410016 - Sequence 391040 from Patent EP1572962.
JD551938 - Sequence 532962 from Patent EP1572962.
JD110230 - Sequence 91254 from Patent EP1572962.
JD251193 - Sequence 232217 from Patent EP1572962.
JD402079 - Sequence 383103 from Patent EP1572962.
JD398829 - Sequence 379853 from Patent EP1572962.
JD133505 - Sequence 114529 from Patent EP1572962.
JD545443 - Sequence 526467 from Patent EP1572962.
JD279000 - Sequence 260024 from Patent EP1572962.
JD064424 - Sequence 45448 from Patent EP1572962.
JD218701 - Sequence 199725 from Patent EP1572962.
JD300884 - Sequence 281908 from Patent EP1572962.
JD354720 - Sequence 335744 from Patent EP1572962.
JD433405 - Sequence 414429 from Patent EP1572962.
JD435276 - Sequence 416300 from Patent EP1572962.
JD257175 - Sequence 238199 from Patent EP1572962.
JD281110 - Sequence 262134 from Patent EP1572962.
JD460431 - Sequence 441455 from Patent EP1572962.
JD284978 - Sequence 266002 from Patent EP1572962.
JD429858 - Sequence 410882 from Patent EP1572962.
JD527455 - Sequence 508479 from Patent EP1572962.
JD299572 - Sequence 280596 from Patent EP1572962.
JD563668 - Sequence 544692 from Patent EP1572962.
JD294382 - Sequence 275406 from Patent EP1572962.
JD464250 - Sequence 445274 from Patent EP1572962.
JD402333 - Sequence 383357 from Patent EP1572962.
JD322353 - Sequence 303377 from Patent EP1572962.
JD283872 - Sequence 264896 from Patent EP1572962.
LF209352 - JP 2014500723-A/16855: Polycomb-Associated Non-Coding RNAs.
JD229451 - Sequence 210475 from Patent EP1572962.
JD299988 - Sequence 281012 from Patent EP1572962.
JD297639 - Sequence 278663 from Patent EP1572962.
JD202841 - Sequence 183865 from Patent EP1572962.
JD503862 - Sequence 484886 from Patent EP1572962.
MA563493 - JP 2018138019-A/135419: Polycomb-Associated Non-Coding RNAs.
MA444927 - JP 2018138019-A/16853: Polycomb-Associated Non-Coding RNAs.
MA444929 - JP 2018138019-A/16855: Polycomb-Associated Non-Coding RNAs.

-  Biochemical and Signaling Pathways
  KEGG - Kyoto Encyclopedia of Genes and Genomes
hsa03050 - Proteasome
hsa04612 - Antigen processing and presentation

Reactome (by CSHL, EBI, and GO)

Protein P61289 (Reactome details) participates in the following event(s):

R-HSA-5665871 ADRM1 binds 26S proteasome
R-HSA-8956140 NEDD8 and UBD bind NUB1 and the 26S proteasome
R-HSA-5665854 ADRM1:26S proteaseome binds UCHL5
R-HSA-5689539 ADRM1:26S proteaseome binds USP14
R-HSA-5689603 UCH proteinases
R-HSA-8951664 Neddylation
R-HSA-5689880 Ub-specific processing proteases
R-HSA-5688426 Deubiquitination
R-HSA-597592 Post-translational protein modification
R-HSA-68827 CDT1 association with the CDC6:ORC:origin complex
R-HSA-68949 Orc1 removal from chromatin
R-HSA-69017 CDK-mediated phosphorylation and removal of Cdc6
R-HSA-69601 Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
R-HSA-69229 Ubiquitin-dependent degradation of Cyclin D1
R-HSA-174178 APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
R-HSA-174154 APC/C:Cdc20 mediated degradation of Securin
R-HSA-2467813 Separation of Sister Chromatids
R-HSA-174113 SCF-beta-TrCP mediated degradation of Emi1
R-HSA-174184 Cdc20:Phospho-APC/C mediated degradation of Cyclin A
R-HSA-180534 Vpu mediated degradation of CD4
R-HSA-180585 Vif-mediated degradation of APOBEC3G
R-HSA-9020702 Interleukin-1 signaling
R-HSA-211733 Regulation of activated PAK-2p34 by proteasome mediated degradation
R-HSA-349425 Autodegradation of the E3 ubiquitin ligase COP1
R-HSA-350562 Regulation of ornithine decarboxylase (ODC)
R-HSA-450408 AUF1 (hnRNP D0) binds and destabilizes mRNA
R-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation
R-HSA-1169091 Activation of NF-kappaB in B cells
R-HSA-1234176 Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
R-HSA-1236974 ER-Phagosome pathway
R-HSA-1236978 Cross-presentation of soluble exogenous antigens (endosomes)
R-HSA-4641258 Degradation of DVL
R-HSA-195253 Degradation of beta-catenin by the destruction complex
R-HSA-4641257 Degradation of AXIN
R-HSA-4608870 Asymmetric localization of PCP proteins
R-HSA-5358346 Hedgehog ligand biogenesis
R-HSA-5362768 Hh mutants that don't undergo autocatalytic processing are degraded by ERAD
R-HSA-202424 Downstream TCR signaling
R-HSA-2871837 FCERI mediated NF-kB activation
R-HSA-5607764 CLEC7A (Dectin-1) signaling
R-HSA-5607761 Dectin-1 mediated noncanonical NF-kB signaling
R-HSA-5676590 NIK-->noncanonical NF-kB signaling
R-HSA-5610785 GLI3 is processed to GLI3R by the proteasome
R-HSA-5610783 Degradation of GLI2 by the proteasome
R-HSA-5610780 Degradation of GLI1 by the proteasome
R-HSA-5632684 Hedgehog 'on' state
R-HSA-5658442 Regulation of RAS by GAPs
R-HSA-5668541 TNFR2 non-canonical NF-kB pathway
R-HSA-5687128 MAPK6/MAPK4 signaling
R-HSA-8948751 Regulation of PTEN stability and activity
R-HSA-69481 G2/M Checkpoints
R-HSA-8852276 The role of GTSE1 in G2/M progression after G2 checkpoint
R-HSA-8854050 FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
R-HSA-382556 ABC-family proteins mediated transport
R-HSA-5678895 Defective CFTR causes cystic fibrosis
R-HSA-8939236 RUNX1 regulates transcription of genes involved in differentiation of HSCs
R-HSA-8939902 Regulation of RUNX2 expression and activity
R-HSA-9010553 Regulation of expression of SLITs and ROBOs
R-HSA-174084 Autodegradation of Cdh1 by Cdh1:APC/C
R-HSA-187577 SCF(Skp2)-mediated degradation of p27/p21
R-HSA-8941858 Regulation of RUNX3 expression and activity
R-HSA-392499 Metabolism of proteins
R-HSA-68867 Assembly of the pre-replicative complex
R-HSA-69052 Switching of origins to a post-replicative state
R-HSA-69610 p53-Independent DNA Damage Response
R-HSA-75815 Ubiquitin-dependent degradation of Cyclin D
R-HSA-174143 APC/C-mediated degradation of cell cycle proteins
R-HSA-176409 APC/C:Cdc20 mediated degradation of mitotic proteins
R-HSA-68882 Mitotic Anaphase
R-HSA-176408 Regulation of APC/C activators between G1/S and early anaphase
R-HSA-179419 APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint
R-HSA-162909 Host Interactions of HIV factors
R-HSA-446652 Interleukin-1 family signaling
R-HSA-169911 Regulation of Apoptosis
R-HSA-69541 Stabilization of p53
R-HSA-351202 Metabolism of polyamines
R-HSA-450531 Regulation of mRNA stability by proteins that bind AU-rich elements
R-HSA-983169 Class I MHC mediated antigen processing & presentation
R-HSA-1168372 Downstream signaling events of B Cell Receptor (BCR)
R-HSA-1234174 Regulation of Hypoxia-inducible Factor (HIF) by oxygen
R-HSA-1236975 Antigen processing-Cross presentation
R-HSA-201681 TCF dependent signaling in response to WNT
R-HSA-195721 Signaling by WNT
R-HSA-4086400 PCP/CE pathway
R-HSA-5358351 Signaling by Hedgehog
R-HSA-5387390 Hh mutants abrogate ligand secretion
R-HSA-202403 TCR signaling
R-HSA-2454202 Fc epsilon receptor (FCERI) signaling
R-HSA-5621481 C-type lectin receptors (CLRs)
R-HSA-5610787 Hedgehog 'off' state
R-HSA-5673001 RAF/MAP kinase cascade
R-HSA-1280215 Cytokine Signaling in Immune system
R-HSA-5683057 MAPK family signaling cascades
R-HSA-6807070 PTEN Regulation
R-HSA-69620 Cell Cycle Checkpoints
R-HSA-69275 G2/M Transition
R-HSA-382551 Transport of small molecules
R-HSA-5619084 ABC transporter disorders
R-HSA-8878171 Transcriptional regulation by RUNX1
R-HSA-8878166 Transcriptional regulation by RUNX2
R-HSA-376176 Signaling by ROBO receptors
R-HSA-69202 Cyclin E associated events during G1/S transition
R-HSA-69656 Cyclin A:Cdk2-associated events at S phase entry
R-HSA-8878159 Transcriptional regulation by RUNX3
R-HSA-69002 DNA Replication Pre-Initiation
R-HSA-69239 Synthesis of DNA
R-HSA-69613 p53-Independent G1/S DNA damage checkpoint
R-HSA-69242 S Phase
R-HSA-453276 Regulation of mitotic cell cycle
R-HSA-176814 Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins
R-HSA-2555396 Mitotic Metaphase and Anaphase
R-HSA-162906 HIV Infection
R-HSA-449147 Signaling by Interleukins
R-HSA-109581 Apoptosis
R-HSA-69563 p53-Dependent G1 DNA Damage Response
R-HSA-71291 Metabolism of nitrogenous molecules
R-HSA-8953854 Metabolism of RNA
R-HSA-1280218 Adaptive Immune System
R-HSA-983705 Signaling by the B Cell Receptor (BCR)
R-HSA-2262749 Cellular response to hypoxia
R-HSA-162582 Signal Transduction
R-HSA-3858494 Beta-catenin independent WNT signaling
R-HSA-5663202 Diseases of signal transduction
R-HSA-168249 Innate Immune System
R-HSA-5684996 MAPK1/MAPK3 signaling
R-HSA-168256 Immune System
R-HSA-1257604 PIP3 activates AKT signaling
R-HSA-1640170 Cell Cycle
R-HSA-453274 Mitotic G2-G2/M phases
R-HSA-5619115 Disorders of transmembrane transporters
R-HSA-212436 Generic Transcription Pathway
R-HSA-422475 Axon guidance
R-HSA-69206 G1/S Transition
R-HSA-68874 M/G1 Transition
R-HSA-69306 DNA Replication
R-HSA-69615 G1/S DNA Damage Checkpoints
R-HSA-69278 Cell Cycle (Mitotic)
R-HSA-68886 M Phase
R-HSA-5663205 Infectious disease
R-HSA-5357801 Programmed Cell Death
R-HSA-69580 p53-Dependent G1/S DNA damage checkpoint
R-HSA-1430728 Metabolism
R-HSA-2262752 Cellular responses to stress
R-HSA-1643685 Disease
R-HSA-9006925 Intracellular signaling by second messengers
R-HSA-73857 RNA Polymerase II Transcription
R-HSA-1266738 Developmental Biology
R-HSA-453279 Mitotic G1-G1/S phases
R-HSA-8953897 Cellular responses to external stimuli
R-HSA-74160 Gene expression (Transcription)

-  Other Names for This Gene
  Alternate Gene Symbols: NM_176863, NP_789839, P61289-2, uc002ibq.3
UCSC ID: uc002ibq.4
RefSeq Accession: NM_176863
Protein: P61289-2, splice isoform of P61289 CCDS: CCDS11442.1, CCDS45689.1

-  Gene Model Information
category: coding nonsense-mediated-decay: no RNA accession: NM_176863.2
exon count: 11CDS single in 3' UTR: no RNA size: 3494
ORF size: 804CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 1596.00frame shift in genome: no % Coverage: 99.48
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.