Human Gene ZNF502 (uc003cnt.3)
  Description: Homo sapiens zinc finger protein 502 (ZNF502), transcript variant 4, mRNA.
Transcript (Including UTRs)
   Position: hg19 chr3:44,754,135-44,765,323 Size: 11,189 Total Exon Count: 3 Strand: +
Coding Region
   Position: hg19 chr3:44,761,754-44,763,944 Size: 2,191 Coding Exon Count: 2 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr3:44,754,135-44,765,323)mRNA (may differ from genome)Protein (544 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
H-INVHGNCLynxMGIneXtProtPubMed
UniProtKBBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: ZN502_HUMAN
DESCRIPTION: RecName: Full=Zinc finger protein 502;
FUNCTION: May be involved in transcriptional regulation.
SUBCELLULAR LOCATION: Nucleus (Potential).
SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein family.
SIMILARITY: Contains 14 C2H2-type zinc fingers.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 5.48 RPKM in Testis
Total median expression: 121.24 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -53.60157-0.341 Picture PostScript Text
3' UTR -427.811379-0.310 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR007087 - Znf_C2H2
IPR015880 - Znf_C2H2-like
IPR013087 - Znf_C2H2/integrase_DNA-bd

Pfam Domains:
PF00096 - Zinc finger, C2H2 type
PF13912 - C2H2-type zinc finger

SCOP Domains:
48695 - Multiheme cytochromes
57667 - C2H2 and C2HC zinc fingers
57889 - Cysteine-rich domain
57903 - FYVE/PHD zinc finger

ModBase Predicted Comparative 3D Structure on Q8TBZ5
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
      
      
      
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0005515 protein binding
GO:0046872 metal ion binding

Biological Process:
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0044791 positive regulation by host of viral release from host cell
GO:0044794 positive regulation by host of viral process

Cellular Component:
GO:0005634 nucleus


-  Descriptions from all associated GenBank mRNAs
  LP896266 - Sequence 1130 from Patent EP3253886.
AK027761 - Homo sapiens cDNA FLJ14855 fis, clone PLACE1000979, moderately similar to ZINC FINGER PROTEIN 135.
BC028377 - Homo sapiens zinc finger protein 502, mRNA (cDNA clone MGC:32901 IMAGE:4822224), complete cds.
JD248040 - Sequence 229064 from Patent EP1572962.
JD252696 - Sequence 233720 from Patent EP1572962.
JD252697 - Sequence 233721 from Patent EP1572962.
JD382264 - Sequence 363288 from Patent EP1572962.
CU688478 - Synthetic construct Homo sapiens gateway clone IMAGE:100020307 5' read ZNF502 mRNA.
AB384986 - Synthetic construct DNA, clone: pF1KB4757, Homo sapiens ZNF502 gene for zinc finger protein 502, complete cds, without stop codon, in Flexi system.
EU446552 - Synthetic construct Homo sapiens clone IMAGE:100070003; IMAGE:100011761; FLH258277.01L zinc finger protein 502 (ZNF502) gene, encodes complete protein.
JF432286 - Synthetic construct Homo sapiens clone IMAGE:100073463 zinc finger protein 502 (ZNF502) gene, encodes complete protein.
KJ895147 - Synthetic construct Homo sapiens clone ccsbBroadEn_04541 ZNF502 gene, encodes complete protein.
AK022577 - Homo sapiens cDNA FLJ12515 fis, clone NT2RM2001771, moderately similar to ZINC FINGER PROTEIN 135.
JD246153 - Sequence 227177 from Patent EP1572962.
JD314816 - Sequence 295840 from Patent EP1572962.
JD314817 - Sequence 295841 from Patent EP1572962.
JD314816 - Sequence 295840 from Patent EP1572962.
JD314817 - Sequence 295841 from Patent EP1572962.
JD314888 - Sequence 295912 from Patent EP1572962.
JD314875 - Sequence 295899 from Patent EP1572962.
JD314882 - Sequence 295906 from Patent EP1572962.
JD328708 - Sequence 309732 from Patent EP1572962.
JD541090 - Sequence 522114 from Patent EP1572962.
JD443579 - Sequence 424603 from Patent EP1572962.
JD287569 - Sequence 268593 from Patent EP1572962.
JD166402 - Sequence 147426 from Patent EP1572962.
JD419212 - Sequence 400236 from Patent EP1572962.
JD488675 - Sequence 469699 from Patent EP1572962.
JD241578 - Sequence 222602 from Patent EP1572962.
JD481164 - Sequence 462188 from Patent EP1572962.
JD092874 - Sequence 73898 from Patent EP1572962.
JD381975 - Sequence 362999 from Patent EP1572962.
JD102414 - Sequence 83438 from Patent EP1572962.
JD504138 - Sequence 485162 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: NM_001134442, NP_149987, Q8TBZ5, ZN502_HUMAN
UCSC ID: uc003cnt.3
RefSeq Accession: NM_001134442
Protein: Q8TBZ5 (aka ZN502_HUMAN or Z502_HUMAN)
CCDS: CCDS2719.1

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: NM_001134442.1
exon count: 3CDS single in 3' UTR: no RNA size: 3186
ORF size: 1635CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 3447.50frame shift in genome: no % Coverage: 99.53
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.