Description: Homo sapiens ubiquitin specific peptidase 45 (USP45), mRNA. RefSeq Summary (NM_001080481): The protein encoded by this gene is a deubiquitylase that binds ERCC1, the catalytic subunit of the XPF-ERCC1 DNA repair endonuclease. This endonuclease is a critical regulator of DNA repair processes, and the deubiquitylase activity of the encoded protein is important for maintaining the DNA repair ability of XPF-ERCC1. [provided by RefSeq, Sep 2016]. Transcript (Including UTRs) Position: hg19 chr6:99,880,184-99,963,252 Size: 83,069 Total Exon Count: 18 Strand: - Coding Region Position: hg19 chr6:99,883,592-99,958,096 Size: 74,505 Coding Exon Count: 17
ID:UBP45_HUMAN DESCRIPTION: RecName: Full=Ubiquitin carboxyl-terminal hydrolase 45; EC=3.4.19.12; AltName: Full=Deubiquitinating enzyme 45; AltName: Full=Ubiquitin thioesterase 45; AltName: Full=Ubiquitin-specific-processing protease 45; CATALYTIC ACTIVITY: Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C- terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal). TISSUE SPECIFICITY: Broadly expressed, with highest levels in ovary, skeletal muscle and spleen. SIMILARITY: Belongs to the peptidase C19 family. SIMILARITY: Contains 1 UBP-type zinc finger. SEQUENCE CAUTION: Sequence=CAI17192.1; Type=Erroneous gene model prediction; Sequence=CAI19761.1; Type=Erroneous gene model prediction;
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Genetic Association Studies of Complex Diseases and Disorders
Genetic Association Database (archive): USP45 CDC HuGE Published Literature: USP45 Positive Disease Associations: Glucose
, Tunica Media Related Studies:
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF00443 - Ubiquitin carboxyl-terminal hydrolase PF02148 - Zn-finger in ubiquitin-hydrolases and other protein PF13423 - Ubiquitin carboxyl-terminal hydrolase
ModBase Predicted Comparative 3D Structure on Q70EL2
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0004843 thiol-dependent ubiquitin-specific protease activity GO:0008233 peptidase activity GO:0008234 cysteine-type peptidase activity GO:0008270 zinc ion binding GO:0016787 hydrolase activity GO:0036459 thiol-dependent ubiquitinyl hydrolase activity GO:0046872 metal ion binding
Biological Process: GO:0006281 DNA repair GO:0006508 proteolysis GO:0006511 ubiquitin-dependent protein catabolic process GO:0016579 protein deubiquitination GO:0070911 global genome nucleotide-excision repair
US Server
