Description: Homo sapiens wingless-type MMTV integration site family, member 8A (WNT8A), mRNA. RefSeq Summary (NM_058244): The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family, and may be implicated in development of early embryos as well as germ cell tumors. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2014]. Transcript (Including UTRs) Position: hg19 chr5:137,419,774-137,427,199 Size: 7,426 Total Exon Count: 6 Strand: + Coding Region Position: hg19 chr5:137,419,779-137,426,762 Size: 6,984 Coding Exon Count: 6
ID:WNT8A_HUMAN DESCRIPTION: RecName: Full=Protein Wnt-8a; AltName: Full=Protein Wnt-8d; Flags: Precursor; FUNCTION: Ligand for members of the frizzled family of seven transmembrane receptors. May play an important role in the development and differentiation of certain forebrain structures, notably the hippocampus. SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix. SIMILARITY: Belongs to the Wnt family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9H1J5
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
BC144497 - Homo sapiens cDNA clone IMAGE:9053024, containing frame-shift errors. AY009402 - Homo sapiens WNT8d precursor (WNT8d) mRNA, complete cds. BC144001 - Homo sapiens cDNA clone IMAGE:9052519, with apparent retained intron. AB057725 - Homo sapiens mRNA for WNT8A, complete cds. AB590697 - Synthetic construct DNA, clone: pFN21AE1833, Homo sapiens WNT8A gene for wingless-type MMTV integration site family, member 8A, without stop codon, in Flexi system. BC156844 - Synthetic construct Homo sapiens clone IMAGE:100062529, MGC:190545 wingless-type MMTV integration site family, member 8A (WNT8A) mRNA, encodes complete protein. DQ570282 - Homo sapiens piRNA piR-30394, complete sequence. JD227012 - Sequence 208036 from Patent EP1572962. JD423444 - Sequence 404468 from Patent EP1572962. JD179599 - Sequence 160623 from Patent EP1572962. JD401231 - Sequence 382255 from Patent EP1572962. JD528889 - Sequence 509913 from Patent EP1572962. JD168515 - Sequence 149539 from Patent EP1572962. JD265619 - Sequence 246643 from Patent EP1572962. JD377223 - Sequence 358247 from Patent EP1572962. JD263006 - Sequence 244030 from Patent EP1572962. JD359164 - Sequence 340188 from Patent EP1572962. JD297024 - Sequence 278048 from Patent EP1572962. JD231233 - Sequence 212257 from Patent EP1572962. JD323752 - Sequence 304776 from Patent EP1572962.
Biochemical and Signaling Pathways
KEGG - Kyoto Encyclopedia of Genes and Genomes hsa04310 - Wnt signaling pathway hsa04340 - Hedgehog signaling pathway hsa04916 - Melanogenesis hsa05200 - Pathways in cancer hsa05217 - Basal cell carcinoma
BioCarta from NCI Cancer Genome Anatomy Project h_wnt-lrp6Pathway - Wnt/LRP6 Signalling
Reactome (by CSHL, EBI, and GO)
Protein Q9H1J5 (Reactome details) participates in the following event(s):
R-HSA-201708 Frizzled receptors bind Wnts R-HSA-3238694 PORCN palmitoleoylates N-glycosyl WNTs R-HSA-1458875 WNT binds to FZD and LRP5/6 R-HSA-3247843 secretion of WNT ligands R-HSA-3247840 WLS binds WNT ligands in the Golgi R-HSA-1504188 FZD recruits DVL to the receptor complex R-HSA-201691 Phosphorylation of LRP5/6 cytoplasmic domain by CSNKI R-NUL-1458902 frog CK1gamma phosphorylates LRP5/6 R-HSA-201677 Phosphorylation of LRP5/6 cytoplasmic domain by membrane-associated GSK3beta R-HSA-1504186 DVL recruits GSK3beta:AXIN1 to the receptor complex R-HSA-373080 Class B/2 (Secretin family receptors) R-HSA-3238698 WNT ligand biogenesis and trafficking R-HSA-201681 TCF dependent signaling in response to WNT R-HSA-500792 GPCR ligand binding R-HSA-195721 Signaling by WNT R-HSA-4641262 Disassembly of the destruction complex and recruitment of AXIN to the membrane R-HSA-372790 Signaling by GPCR R-HSA-162582 Signal Transduction
US Server
