Human Gene TATDN2 (uc003bvf.3)
Description: Homo sapiens TatD DNase domain containing 2 (TATDN2), mRNA.
Transcript (Including UTRs)
Position: hg19 chr3:10,290,177-10,322,906 Size: 32,730 Total Exon Count: 8 Strand: +
Coding Region
Position: hg19 chr3:10,290,885-10,320,709 Size: 29,825 Coding Exon Count: 6
Data last updated at UCSC: 2013-06-14
Sequence and Links to Tools and Databases
Comments and Description Text from UniProtKB
ID: TATD2_HUMAN
DESCRIPTION: RecName: Full=Putative deoxyribonuclease TATDN2; EC=3.1.21.-;
FUNCTION: Putative deoxyribonuclease (By similarity).COFACTOR: Binds 2 divalent metal cations per subunit (By similarity).SUBCELLULAR LOCATION: Nucleus (Potential).SIMILARITY: Belongs to the TatD DNase family.SEQUENCE CAUTION: Sequence=BAA13208.2; Type=Erroneous initiation;
Primer design for this transcript
Genetic Association Studies of Complex Diseases and Disorders
Genetic Association Database (archive): TATDN2
CDC HuGE Published Literature: TATDN2
Comparative Toxicogenomics Database (CTD)
The following chemicals interact with this gene
Common Gene Haplotype Alleles
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RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
Microarray Expression Data
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mRNA Secondary Structure of 3' and 5' UTRs
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Protein Domain and Structure Information
InterPro Domains: Graphical view of domain structure IPR018228 - DNase_TatD-rel_CS
IPR001130 - TatD_family
Pfam Domains: PF01026 - TatD related DNase
SCOP Domains: 51556 - Metallo-dependent hydrolases
ModBase Predicted Comparative 3D Structure on Q93075
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Descriptions from all associated GenBank mRNAs
D86972 - Homo sapiens mRNA for KIAA0218 gene.AK289794 - Homo sapiens cDNA FLJ76748 complete cds, highly similar to Homo sapiens TatD DNase domain containing 2 (TATDN2), mRNA.DQ571531 - Homo sapiens piRNA piR-31643, complete sequence.JD508521 - Sequence 489545 from Patent EP1572962.BC090935 - Homo sapiens TatD DNase domain containing 2, mRNA (cDNA clone MGC:104979 IMAGE:3064714), complete cds.JD560332 - Sequence 541356 from Patent EP1572962.BC101776 - Homo sapiens TatD DNase domain containing 2, mRNA (cDNA clone MGC:126825 IMAGE:8069282), complete cds.BC101770 - Homo sapiens TatD DNase domain containing 2, mRNA (cDNA clone MGC:126819 IMAGE:8069276), complete cds.JD061152 - Sequence 42176 from Patent EP1572962.AB383807 - Synthetic construct DNA, clone: pF1KSDA0218, Homo sapiens TATDN2 gene for TatD DNase domain-containing deoxyribonuclease 2, complete cds, without stop codon, in Flexi system.DQ588061 - Homo sapiens piRNA piR-55173, complete sequence.EU789553 - Homo sapiens clone TATDN2-T1 TATDN2/GHRLOS fusion mRNA, complete sequence.EU789554 - Homo sapiens clone TATDN2-T2 TATDN2/GHRLOS fusion mRNA, complete sequence.DQ596381 - Homo sapiens piRNA piR-34447, complete sequence.DQ575373 - Homo sapiens piRNA piR-43485, complete sequence.DQ584136 - Homo sapiens piRNA piR-51248, complete sequence.DQ573723 - Homo sapiens piRNA piR-41835, complete sequence.DQ572137 - Homo sapiens piRNA piR-40249, complete sequence.DQ575202 - Homo sapiens piRNA piR-43314, complete sequence.DQ593741 - Homo sapiens piRNA piR-33853, complete sequence.DQ571166 - Homo sapiens piRNA piR-31278, complete sequence.DQ596273 - Homo sapiens piRNA piR-34339, complete sequence.DQ570943 - Homo sapiens piRNA piR-31055, complete sequence.DQ586656 - Homo sapiens piRNA piR-53768, complete sequence.DQ586657 - Homo sapiens piRNA piR-53769, complete sequence.DQ590453 - Homo sapiens piRNA piR-57565, complete sequence.DQ575623 - Homo sapiens piRNA piR-43735, complete sequence.DQ588764 - Homo sapiens piRNA piR-55876, complete sequence.DQ571266 - Homo sapiens piRNA piR-31378, complete sequence.DQ588207 - Homo sapiens piRNA piR-55319, complete sequence.DQ574446 - Homo sapiens piRNA piR-42558, complete sequence.AK311203 - Homo sapiens cDNA, FLJ18245.DQ577121 - Homo sapiens piRNA piR-45233, complete sequence.DQ585176 - Homo sapiens piRNA piR-52288, complete sequence.DQ585387 - Homo sapiens piRNA piR-52499, complete sequence.JD383124 - Sequence 364148 from Patent EP1572962.JD466256 - Sequence 447280 from Patent EP1572962.DQ571190 - Homo sapiens piRNA piR-31302, complete sequence.DQ571191 - Homo sapiens piRNA piR-31303, complete sequence.DQ571192 - Homo sapiens piRNA piR-31304, complete sequence.JD361523 - Sequence 342547 from Patent EP1572962.JD357644 - Sequence 338668 from Patent EP1572962.JD514697 - Sequence 495721 from Patent EP1572962.JD545104 - Sequence 526128 from Patent EP1572962.JD220679 - Sequence 201703 from Patent EP1572962.JD215385 - Sequence 196409 from Patent EP1572962.EU789547 - Homo sapiens clone UIS520-CAGE ghrelin splice variant antisense RNA (GHRLOS), partial sequence, alternatively spliced.EU789548 - Homo sapiens clone UIS512-CAGE ghrelin splice variant antisense RNA (GHRLOS), partial sequence, alternatively spliced.EU789549 - Homo sapiens clone UIS508-CAGE ghrelin splice variant antisense RNA (GHRLOS), partial sequence, alternatively spliced.EU789550 - Homo sapiens clone UIS506-CAGE ghrelin splice variant antisense RNA (GHRLOS), partial sequence, alternatively spliced.EU789551 - Homo sapiens clone UIS502-CAGE ghrelin splice variant antisense RNA (GHRLOS), partial sequence, alternatively spliced.EU789552 - Homo sapiens clone UIS500-CAGE ghrelin splice variant antisense RNA (GHRLOS), partial sequence, alternatively spliced.JD237820 - Sequence 218844 from Patent EP1572962.JD349032 - Sequence 330056 from Patent EP1572962.JD482532 - Sequence 463556 from Patent EP1572962.JD219319 - Sequence 200343 from Patent EP1572962.JD043994 - Sequence 25018 from Patent EP1572962.JD066575 - Sequence 47599 from Patent EP1572962.DQ591352 - Homo sapiens piRNA piR-58464, complete sequence.JD039910 - Sequence 20934 from Patent EP1572962.JD375556 - Sequence 356580 from Patent EP1572962.JD500907 - Sequence 481931 from Patent EP1572962.JD473497 - Sequence 454521 from Patent EP1572962.JD103497 - Sequence 84521 from Patent EP1572962.JD330291 - Sequence 311315 from Patent EP1572962.JD379518 - Sequence 360542 from Patent EP1572962.JD449411 - Sequence 430435 from Patent EP1572962.JD561710 - Sequence 542734 from Patent EP1572962.JD128544 - Sequence 109568 from Patent EP1572962.JD391385 - Sequence 372409 from Patent EP1572962.JD276616 - Sequence 257640 from Patent EP1572962.JD276617 - Sequence 257641 from Patent EP1572962.JD100178 - Sequence 81202 from Patent EP1572962.JD300637 - Sequence 281661 from Patent EP1572962.JD220846 - Sequence 201870 from Patent EP1572962.JD496134 - Sequence 477158 from Patent EP1572962.JD331820 - Sequence 312844 from Patent EP1572962.JD350535 - Sequence 331559 from Patent EP1572962.JD555412 - Sequence 536436 from Patent EP1572962.DQ589761 - Homo sapiens piRNA piR-56873, complete sequence.JD492332 - Sequence 473356 from Patent EP1572962.JD435308 - Sequence 416332 from Patent EP1572962.JD226917 - Sequence 207941 from Patent EP1572962.JD528618 - Sequence 509642 from Patent EP1572962.JD418310 - Sequence 399334 from Patent EP1572962.EU789528 - Homo sapiens clone 5RLM-RACE-I ghrelin splice variant antisense RNA (GHRLOS), partial sequence, alternatively spliced.EU789529 - Homo sapiens clone 5RLM-RACE-II ghrelin splice variant antisense RNA (GHRLOS), partial sequence, alternatively spliced.EU789530 - Homo sapiens clone 5RLM-RACE-III ghrelin splice variant antisense RNA (GHRLOS), partial sequence, alternatively spliced.EU789538 - Homo sapiens clone E-UIS927 ghrelin splice variant antisense RNA (GHRLOS), partial sequence, alternatively spliced.EU789534 - Homo sapiens clone A-UIS935 ghrelin splice variant antisense RNA (GHRLOS), partial sequence, alternatively spliced.EU789535 - Homo sapiens clone B-UIS933 ghrelin splice variant antisense RNA (GHRLOS), partial sequence, alternatively spliced.EU789536 - Homo sapiens clone C-UIS930 ghrelin splice variant antisense RNA (GHRLOS), partial sequence, alternatively spliced.EU789537 - Homo sapiens clone D-UIS928 ghrelin splice variant antisense RNA (GHRLOS), partial sequence, alternatively spliced.EU789539 - Homo sapiens clone F-UIS925 ghrelin splice variant antisense RNA (GHRLOS), partial sequence, alternatively spliced.EU789540 - Homo sapiens clone G-UIS324 ghrelin splice variant antisense RNA (GHRLOS), partial sequence, alternatively spliced.EU789541 - Homo sapiens clone H-UIS334 ghrelin splice variant antisense RNA (GHRLOS), partial sequence, alternatively spliced.EU789542 - Homo sapiens clone I-UIS520 ghrelin splice variant antisense RNA (GHRLOS), partial sequence, alternatively spliced.EU789543 - Homo sapiens clone J-UIS526 ghrelin splice variant antisense RNA (GHRLOS), partial sequence, alternatively spliced.EU789544 - Homo sapiens clone K-UIS529 ghrelin splice variant antisense RNA (GHRLOS), partial sequence, alternatively spliced.EU789545 - Homo sapiens clone L-UIS502 ghrelin splice variant antisense RNA (GHRLOS), partial sequence, alternatively spliced.EU789546 - Homo sapiens clone M-UIS510 ghrelin splice variant antisense RNA (GHRLOS), partial sequence, alternatively spliced.JD049810 - Sequence 30834 from Patent EP1572962.JD093465 - Sequence 74489 from Patent EP1572962.JD184060 - Sequence 165084 from Patent EP1572962.JD154523 - Sequence 135547 from Patent EP1572962.
Biochemical and Signaling Pathways
Other Names for This Gene
Alternate Gene Symbols: KIAA0218, NM_014760, NP_055575, Q3MIL9, Q5BKU0, Q93075, TATD2_HUMANUCSC ID: uc003bvf.3RefSeq Accession: NM_014760
Protein: Q93075
(aka TATD2_HUMAN or TAT2_HUMAN)
CCDS: CCDS33698.1
Gene Model Information
category:
coding
nonsense-mediated-decay:
no
RNA accession:
NM_014760.3
exon count:
8 CDS single in 3' UTR:
no
RNA size:
4909
ORF size:
2286 CDS single in intron:
no
Alignment % ID:
100.00
txCdsPredict score:
3786.00 frame shift in genome:
no
% Coverage:
99.96
has start codon:
yes
stop codon in genome:
no
# of Alignments:
1
has end codon:
yes
retained intron:
yes
# AT/AC introns
0
selenocysteine:
no
end bleed into intron:
0 # strange splices:
0
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Methods, Credits, and Use Restrictions
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for details on how this gene model was made and data restrictions if any.