Human Gene ZNF71 (uc002qnm.4)
  Description: Homo sapiens zinc finger protein 71 (ZNF71), mRNA.
Transcript (Including UTRs)
   Position: hg19 chr19:57,106,664-57,135,544 Size: 28,881 Total Exon Count: 3 Strand: +
Coding Region
   Position: hg19 chr19:57,132,656-57,134,125 Size: 1,470 Coding Exon Count: 1 

Page IndexSequence and LinksUniProtKB CommentsPrimersGenetic AssociationsMalaCards
CTDGene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein Structure
Other SpeciesGO AnnotationsmRNA DescriptionsPathwaysOther NamesModel Information
Methods
Data last updated at UCSC: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr19:57,106,664-57,135,544)mRNA (may differ from genome)Protein (489 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGeneCardsGeneNetwork
H-INVHGNCHPRDLynxMalacardsMGI
neXtProtOMIMPubMedReactomeTreefamUniProtKB
WikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: ZNF71_HUMAN
DESCRIPTION: RecName: Full=Endothelial zinc finger protein induced by tumor necrosis factor alpha; AltName: Full=Zinc finger protein 71;
FUNCTION: May be involved in transcriptional regulation.
SUBCELLULAR LOCATION: Nucleus (Potential).
TISSUE SPECIFICITY: Highly expressed in placenta, followed by brain, testis, pancreas, heart, small intestine, muscle, uterus, prostate and peripheral blood leukocytes. Not detected in liver, lung, colon, stomach, salivary and thyroid gland.
INDUCTION: By TNF.
SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein family.
SIMILARITY: Contains 13 C2H2-type zinc fingers.
SEQUENCE CAUTION: Sequence=AAD23608.1; Type=Erroneous initiation;

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database (archive): ZNF71
CDC HuGE Published Literature: ZNF71

-  MalaCards Disease Associations
  MalaCards Gene Search: ZNF71
Diseases sorted by gene-association score: hypotrichosis 1 (1)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 2.57 RPKM in Uterus
Total median expression: 78.38 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -125.40238-0.527 Picture PostScript Text
3' UTR -498.001419-0.351 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR007087 - Znf_C2H2
IPR015880 - Znf_C2H2-like
IPR013087 - Znf_C2H2/integrase_DNA-bd

Pfam Domains:
PF00096 - Zinc finger, C2H2 type
PF12874 - Zinc-finger of C2H2 type
PF13894 - C2H2-type zinc finger
PF13912 - C2H2-type zinc finger

SCOP Domains:
48695 - Multiheme cytochromes
57667 - C2H2 and C2HC zinc fingers

ModBase Predicted Comparative 3D Structure on Q9NQZ8
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
      
      
      
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003700 transcription factor activity, sequence-specific DNA binding
GO:0046872 metal ion binding

Biological Process:
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription from RNA polymerase II promoter

Cellular Component:
GO:0005634 nucleus


-  Descriptions from all associated GenBank mRNAs
  BC014280 - Homo sapiens zinc finger protein 71, mRNA (cDNA clone MGC:11153 IMAGE:3840512), complete cds.
JD485565 - Sequence 466589 from Patent EP1572962.
JD472901 - Sequence 453925 from Patent EP1572962.
JD383030 - Sequence 364054 from Patent EP1572962.
JD195038 - Sequence 176062 from Patent EP1572962.
AF269249 - Homo sapiens endothelial zinc finger protein induced by tumor necrosis factor alpha (EZFIT) mRNA, complete cds.
JD368954 - Sequence 349978 from Patent EP1572962.
AX721136 - Sequence 96 from Patent WO0220754.
CU676957 - Synthetic construct Homo sapiens gateway clone IMAGE:100017360 5' read ZNF71 mRNA.
AB529316 - Synthetic construct DNA, clone: pF1KB9669, Homo sapiens ZNF71 gene for zinc finger protein 71, without stop codon, in Flexi system.
KJ899385 - Synthetic construct Homo sapiens clone ccsbBroadEn_08779 ZNF71 gene, encodes complete protein.
AK057019 - Homo sapiens cDNA FLJ32457 fis, clone SKNMC1000026, highly similar to Homo sapiens endothelial zinc finger protein induced by tumor necrosis factor alpha (EZFIT) mRNA.
DL492511 - Novel nucleic acids.
DL490980 - Novel nucleic acids.
DL490980 - Novel nucleic acids.
DL491906 - Novel nucleic acids.
DL490469 - Novel nucleic acids.
JD538028 - Sequence 519052 from Patent EP1572962.
JD548989 - Sequence 530013 from Patent EP1572962.
JD541013 - Sequence 522037 from Patent EP1572962.
JD226959 - Sequence 207983 from Patent EP1572962.
JD487037 - Sequence 468061 from Patent EP1572962.
JD471043 - Sequence 452067 from Patent EP1572962.
JD180542 - Sequence 161566 from Patent EP1572962.
JD444045 - Sequence 425069 from Patent EP1572962.
JD126902 - Sequence 107926 from Patent EP1572962.
JD441851 - Sequence 422875 from Patent EP1572962.
JD073332 - Sequence 54356 from Patent EP1572962.
JD362934 - Sequence 343958 from Patent EP1572962.
JD369642 - Sequence 350666 from Patent EP1572962.
JD095755 - Sequence 76779 from Patent EP1572962.
JD158375 - Sequence 139399 from Patent EP1572962.
JD274172 - Sequence 255196 from Patent EP1572962.
JD219393 - Sequence 200417 from Patent EP1572962.
JD346180 - Sequence 327204 from Patent EP1572962.
JD506425 - Sequence 487449 from Patent EP1572962.
JD350262 - Sequence 331286 from Patent EP1572962.
JD313397 - Sequence 294421 from Patent EP1572962.
JD385684 - Sequence 366708 from Patent EP1572962.
JD564756 - Sequence 545780 from Patent EP1572962.
JD550005 - Sequence 531029 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein Q9NQZ8 (Reactome details) participates in the following event(s):

R-HSA-975040 KRAB-ZNF / KAP Interaction
R-HSA-212436 Generic Transcription Pathway
R-HSA-73857 RNA Polymerase II Transcription
R-HSA-74160 Gene expression (Transcription)

-  Other Names for This Gene
  Alternate Gene Symbols: EZFIT, NM_021216, NP_067039, Q15919, Q9NQZ8, Q9UC09, Q9UQD3, ZNF71_HUMAN
UCSC ID: uc002qnm.4
RefSeq Accession: NM_021216
Protein: Q9NQZ8 (aka ZNF71_HUMAN or ZN71_HUMAN)
CCDS: CCDS12947.1

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: NM_021216.4
exon count: 3CDS single in 3' UTR: no RNA size: 3144
ORF size: 1470CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 3087.00frame shift in genome: no % Coverage: 99.46
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.