Human Gene TRIM67 (uc009xfn.1)
Description: Homo sapiens tripartite motif containing 67 (TRIM67), mRNA.
Transcript (Including UTRs)
Position: hg19 chr1:231,298,674-231,357,314 Size: 58,641 Total Exon Count: 10 Strand: +
Coding Region
Position: hg19 chr1:231,298,716-231,351,186 Size: 52,471 Coding Exon Count: 10
Data last updated at UCSC: 2013-06-14
Sequence and Links to Tools and Databases
Comments and Description Text from UniProtKB
ID: TRI67_HUMAN
DESCRIPTION: RecName: Full=Tripartite motif-containing protein 67; AltName: Full=TRIM9-like protein;
SUBCELLULAR LOCATION: Cytoplasm (By similarity). Cytoplasm, cytoskeleton (By similarity). Note=Microtubule-associated (By similarity).SIMILARITY: Belongs to the TRIM/RBCC family.SIMILARITY: Contains 2 B box-type zinc fingers.SIMILARITY: Contains 1 B30.2/SPRY domain.SIMILARITY: Contains 1 COS domain.SIMILARITY: Contains 1 fibronectin type-III domain.SIMILARITY: Contains 1 RING-type zinc finger.SEQUENCE CAUTION: Sequence=BAC86689.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact;
Primer design for this transcript
Genetic Association Studies of Complex Diseases and Disorders
Genetic Association Database (archive): TRIM67
CDC HuGE Published Literature: TRIM67
Positive Disease Associations: Heart Rate
Related Studies: Heart Rate , , .
[PubMed 0 ]
Comparative Toxicogenomics Database (CTD)
The following chemicals interact with this gene
Common Gene Haplotype Alleles
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RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
Microarray Expression Data
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mRNA Secondary Structure of 3' and 5' UTRs
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Protein Domain and Structure Information
InterPro Domains: Graphical view of domain structure IPR001870 - B30.2/SPRY
IPR003649 - Bbox_C
IPR008985 - ConA-like_lec_gl_sf
IPR017903 - COS_domain
IPR003961 - Fibronectin_type3
IPR013783 - Ig-like_fold
IPR003877 - SPRY_rcpt
IPR000315 - Znf_B-box
IPR001841 - Znf_RING
IPR013083 - Znf_RING/FYVE/PHD
IPR017907 - Znf_RING_CS
Pfam Domains: PF00041 - Fibronectin type III domain
PF00097 - Zinc finger, C3HC4 type (RING finger)
PF00622 - SPRY domain
PF00643 - B-box zinc finger
PF13445 - RING-type zinc-finger
SCOP Domains: 49265 - Fibronectin type III
49899 - Concanavalin A-like lectins/glucanases
57845 - B-box zinc-binding domain
57850 - RING/U-box
ModBase Predicted Comparative 3D Structure on Q6ZTA4
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Mouse Rat Zebrafish D. melanogaster C. elegans S. cerevisiae
No ortholog No ortholog No ortholog No ortholog No ortholog No ortholog
Gene Details
Gene Sorter
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0008270 zinc ion binding
GO:0046872 metal ion binding
Biological Process: GO:0010976 positive regulation of neuron projection development
GO:0046580 negative regulation of Ras protein signal transduction
GO:1903827 regulation of cellular protein localization
GO:2000060 positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
Cellular Component: GO:0005622 intracellular
GO:0005737 cytoplasm
GO:0005856 cytoskeleton
Descriptions from all associated GenBank mRNAs
AK126782 - Homo sapiens cDNA FLJ44831 fis, clone BRACE3047482, moderately similar to Homo sapiens tripartite motif-containing 9 (TRIM9).BC156316 - Synthetic construct Homo sapiens clone IMAGE:100061731, MGC:190085 tripartite motif-containing 67 (TRIM67) mRNA, encodes complete protein.BC157055 - Synthetic construct Homo sapiens clone IMAGE:100063343, MGC:190749 tripartite motif-containing 67 (TRIM67) mRNA, encodes complete protein.AY253917 - Homo sapiens TRIM9-like protein TNL (TNL) mRNA, complete cds.JD042747 - Sequence 23771 from Patent EP1572962.AK055338 - Homo sapiens cDNA FLJ30776 fis, clone FEBRA2000793.JD117677 - Sequence 98701 from Patent EP1572962.JD137458 - Sequence 118482 from Patent EP1572962.JD548546 - Sequence 529570 from Patent EP1572962.JD369917 - Sequence 350941 from Patent EP1572962.JD328129 - Sequence 309153 from Patent EP1572962.JD438344 - Sequence 419368 from Patent EP1572962.JD487299 - Sequence 468323 from Patent EP1572962.JD559153 - Sequence 540177 from Patent EP1572962.JD284002 - Sequence 265026 from Patent EP1572962.JD209842 - Sequence 190866 from Patent EP1572962.JD291441 - Sequence 272465 from Patent EP1572962.JD453139 - Sequence 434163 from Patent EP1572962.CR627464 - Homo sapiens mRNA; cDNA DKFZp547N093 (from clone DKFZp547N093).JD485493 - Sequence 466517 from Patent EP1572962.JD483345 - Sequence 464369 from Patent EP1572962.JD150686 - Sequence 131710 from Patent EP1572962.JD254507 - Sequence 235531 from Patent EP1572962.JD559011 - Sequence 540035 from Patent EP1572962.JD546389 - Sequence 527413 from Patent EP1572962.JD417016 - Sequence 398040 from Patent EP1572962.JD465599 - Sequence 446623 from Patent EP1572962.JD384475 - Sequence 365499 from Patent EP1572962.JD544554 - Sequence 525578 from Patent EP1572962.JD563291 - Sequence 544315 from Patent EP1572962.JD538978 - Sequence 520002 from Patent EP1572962.JD275341 - Sequence 256365 from Patent EP1572962.JD154554 - Sequence 135578 from Patent EP1572962.JD107693 - Sequence 88717 from Patent EP1572962.JD370730 - Sequence 351754 from Patent EP1572962.JD251273 - Sequence 232297 from Patent EP1572962.JD279713 - Sequence 260737 from Patent EP1572962.JD277052 - Sequence 258076 from Patent EP1572962.JD374664 - Sequence 355688 from Patent EP1572962.JD557914 - Sequence 538938 from Patent EP1572962.JD084786 - Sequence 65810 from Patent EP1572962.JD154010 - Sequence 135034 from Patent EP1572962.JD261508 - Sequence 242532 from Patent EP1572962.JD412447 - Sequence 393471 from Patent EP1572962.JD065764 - Sequence 46788 from Patent EP1572962.JD533929 - Sequence 514953 from Patent EP1572962.JD203261 - Sequence 184285 from Patent EP1572962.JD221521 - Sequence 202545 from Patent EP1572962.JD408693 - Sequence 389717 from Patent EP1572962.JD214039 - Sequence 195063 from Patent EP1572962.JD141964 - Sequence 122988 from Patent EP1572962.JD067990 - Sequence 49014 from Patent EP1572962.JD560408 - Sequence 541432 from Patent EP1572962.JD122485 - Sequence 103509 from Patent EP1572962.
Other Names for This Gene
Alternate Gene Symbols: NM_001004342, NP_001004342, Q5TER7, Q5TER8, Q6ZTA4, Q7Z4K7, TNL, TRI67_HUMANUCSC ID: uc009xfn.1RefSeq Accession: NM_001004342
Protein: Q6ZTA4
(aka TRI67_HUMAN)
CCDS: CCDS44333.1
Gene Model Information
category:
coding
nonsense-mediated-decay:
no
RNA accession:
NM_001004342.3
exon count:
10 CDS single in 3' UTR:
no
RNA size:
8522
ORF size:
2352 CDS single in intron:
no
Alignment % ID:
100.00
txCdsPredict score:
4901.00 frame shift in genome:
no
% Coverage:
100.00
has start codon:
yes
stop codon in genome:
no
# of Alignments:
1
has end codon:
yes
retained intron:
no
# AT/AC introns
0
selenocysteine:
no
end bleed into intron:
0 # strange splices:
0
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Methods, Credits, and Use Restrictions
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for details on how this gene model was made and data restrictions if any.