Human Gene TRIM67 (uc009xfn.1)
  Description: Homo sapiens tripartite motif containing 67 (TRIM67), mRNA.
Transcript (Including UTRs)
   Position: hg19 chr1:231,298,674-231,357,314 Size: 58,641 Total Exon Count: 10 Strand: +
Coding Region
   Position: hg19 chr1:231,298,716-231,351,186 Size: 52,471 Coding Exon Count: 10 

Page IndexSequence and LinksUniProtKB CommentsPrimersGenetic AssociationsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
GO AnnotationsmRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr1:231,298,674-231,357,314)mRNA (may differ from genome)Protein (783 aa)
Gene SorterGenome BrowserOther Species FASTATable SchemaAlphaFoldBioGPS
EnsemblEntrez GeneExonPrimerGeneCardsGeneNetworkH-INV
HGNCHPRDLynxMGIneXtProtOMIM
PubMedUniProtKBBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: TRI67_HUMAN
DESCRIPTION: RecName: Full=Tripartite motif-containing protein 67; AltName: Full=TRIM9-like protein;
SUBCELLULAR LOCATION: Cytoplasm (By similarity). Cytoplasm, cytoskeleton (By similarity). Note=Microtubule-associated (By similarity).
SIMILARITY: Belongs to the TRIM/RBCC family.
SIMILARITY: Contains 2 B box-type zinc fingers.
SIMILARITY: Contains 1 B30.2/SPRY domain.
SIMILARITY: Contains 1 COS domain.
SIMILARITY: Contains 1 fibronectin type-III domain.
SIMILARITY: Contains 1 RING-type zinc finger.
SEQUENCE CAUTION: Sequence=BAC86689.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact;

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database (archive): TRIM67
CDC HuGE Published Literature: TRIM67
Positive Disease Associations: Heart Rate
Related Studies:
  1. Heart Rate
    , , . [PubMed 0]

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 7.42 RPKM in Brain - Cerebellum
Total median expression: 22.28 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -15.2042-0.362 Picture PostScript Text
3' UTR -2166.406128-0.354 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR001870 - B30.2/SPRY
IPR003649 - Bbox_C
IPR008985 - ConA-like_lec_gl_sf
IPR017903 - COS_domain
IPR003961 - Fibronectin_type3
IPR013783 - Ig-like_fold
IPR003877 - SPRY_rcpt
IPR000315 - Znf_B-box
IPR001841 - Znf_RING
IPR013083 - Znf_RING/FYVE/PHD
IPR017907 - Znf_RING_CS

Pfam Domains:
PF00041 - Fibronectin type III domain
PF00097 - Zinc finger, C3HC4 type (RING finger)
PF00622 - SPRY domain
PF00643 - B-box zinc finger
PF13445 - RING-type zinc-finger

SCOP Domains:
49265 - Fibronectin type III
49899 - Concanavalin A-like lectins/glucanases
57845 - B-box zinc-binding domain
57850 - RING/U-box

ModBase Predicted Comparative 3D Structure on Q6ZTA4
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
      
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0008270 zinc ion binding
GO:0046872 metal ion binding

Biological Process:
GO:0010976 positive regulation of neuron projection development
GO:0046580 negative regulation of Ras protein signal transduction
GO:1903827 regulation of cellular protein localization
GO:2000060 positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process

Cellular Component:
GO:0005622 intracellular
GO:0005737 cytoplasm
GO:0005856 cytoskeleton


-  Descriptions from all associated GenBank mRNAs
  AK126782 - Homo sapiens cDNA FLJ44831 fis, clone BRACE3047482, moderately similar to Homo sapiens tripartite motif-containing 9 (TRIM9).
BC156316 - Synthetic construct Homo sapiens clone IMAGE:100061731, MGC:190085 tripartite motif-containing 67 (TRIM67) mRNA, encodes complete protein.
BC157055 - Synthetic construct Homo sapiens clone IMAGE:100063343, MGC:190749 tripartite motif-containing 67 (TRIM67) mRNA, encodes complete protein.
AY253917 - Homo sapiens TRIM9-like protein TNL (TNL) mRNA, complete cds.
JD042747 - Sequence 23771 from Patent EP1572962.
AK055338 - Homo sapiens cDNA FLJ30776 fis, clone FEBRA2000793.
JD117677 - Sequence 98701 from Patent EP1572962.
JD137458 - Sequence 118482 from Patent EP1572962.
JD548546 - Sequence 529570 from Patent EP1572962.
JD369917 - Sequence 350941 from Patent EP1572962.
JD328129 - Sequence 309153 from Patent EP1572962.
JD438344 - Sequence 419368 from Patent EP1572962.
JD487299 - Sequence 468323 from Patent EP1572962.
JD559153 - Sequence 540177 from Patent EP1572962.
JD284002 - Sequence 265026 from Patent EP1572962.
JD209842 - Sequence 190866 from Patent EP1572962.
JD291441 - Sequence 272465 from Patent EP1572962.
JD453139 - Sequence 434163 from Patent EP1572962.
CR627464 - Homo sapiens mRNA; cDNA DKFZp547N093 (from clone DKFZp547N093).
JD485493 - Sequence 466517 from Patent EP1572962.
JD483345 - Sequence 464369 from Patent EP1572962.
JD150686 - Sequence 131710 from Patent EP1572962.
JD254507 - Sequence 235531 from Patent EP1572962.
JD559011 - Sequence 540035 from Patent EP1572962.
JD546389 - Sequence 527413 from Patent EP1572962.
JD417016 - Sequence 398040 from Patent EP1572962.
JD465599 - Sequence 446623 from Patent EP1572962.
JD384475 - Sequence 365499 from Patent EP1572962.
JD544554 - Sequence 525578 from Patent EP1572962.
JD563291 - Sequence 544315 from Patent EP1572962.
JD538978 - Sequence 520002 from Patent EP1572962.
JD275341 - Sequence 256365 from Patent EP1572962.
JD154554 - Sequence 135578 from Patent EP1572962.
JD107693 - Sequence 88717 from Patent EP1572962.
JD370730 - Sequence 351754 from Patent EP1572962.
JD251273 - Sequence 232297 from Patent EP1572962.
JD279713 - Sequence 260737 from Patent EP1572962.
JD277052 - Sequence 258076 from Patent EP1572962.
JD374664 - Sequence 355688 from Patent EP1572962.
JD557914 - Sequence 538938 from Patent EP1572962.
JD084786 - Sequence 65810 from Patent EP1572962.
JD154010 - Sequence 135034 from Patent EP1572962.
JD261508 - Sequence 242532 from Patent EP1572962.
JD412447 - Sequence 393471 from Patent EP1572962.
JD065764 - Sequence 46788 from Patent EP1572962.
JD533929 - Sequence 514953 from Patent EP1572962.
JD203261 - Sequence 184285 from Patent EP1572962.
JD221521 - Sequence 202545 from Patent EP1572962.
JD408693 - Sequence 389717 from Patent EP1572962.
JD214039 - Sequence 195063 from Patent EP1572962.
JD141964 - Sequence 122988 from Patent EP1572962.
JD067990 - Sequence 49014 from Patent EP1572962.
JD560408 - Sequence 541432 from Patent EP1572962.
JD122485 - Sequence 103509 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: NM_001004342, NP_001004342, Q5TER7, Q5TER8, Q6ZTA4, Q7Z4K7, TNL, TRI67_HUMAN
UCSC ID: uc009xfn.1
RefSeq Accession: NM_001004342
Protein: Q6ZTA4 (aka TRI67_HUMAN)
CCDS: CCDS44333.1

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: NM_001004342.3
exon count: 10CDS single in 3' UTR: no RNA size: 8522
ORF size: 2352CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 4901.00frame shift in genome: no % Coverage: 100.00
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.