Human Gene SCRT2 (uc002wec.3)
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Sequence and Links to Tools and Databases
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Comments and Description Text from UniProtKB
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ID: SCRT2_HUMAN
DESCRIPTION: RecName: Full=Transcriptional repressor scratch 2; AltName: Full=Scratch homolog 2 zinc finger protein;
FUNCTION: May be involved in transcriptional regulation. SUBCELLULAR LOCATION: Nucleus (Potential). SIMILARITY: Belongs to the snail C2H2-type zinc-finger protein family. SIMILARITY: Contains 5 C2H2-type zinc fingers.
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Primer design for this transcript
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Comparative Toxicogenomics Database (CTD)
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The following chemicals interact with this gene
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Common Gene Haplotype Alleles
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RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
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Microarray Expression Data
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mRNA Secondary Structure of 3' and 5' UTRs
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The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
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Protein Domain and Structure Information
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InterPro Domains: Graphical view of domain structure IPR007087 - Znf_C2H2
IPR015880 - Znf_C2H2-like
IPR013087 - Znf_C2H2/integrase_DNA-bd
Pfam Domains: PF00096 - Zinc finger, C2H2 type
PF12874 - Zinc-finger of C2H2 type
PF13894 - C2H2-type zinc finger
PF13912 - C2H2-type zinc finger
SCOP Domains: 57667 - C2H2 and C2HC zinc fingers
ModBase Predicted Comparative 3D Structure on Q9NQ03
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
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Orthologous Genes in Other Species
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Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
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Gene Ontology (GO) Annotations with Structured Vocabulary
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Molecular Function: GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding
GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0046872 metal ion binding
Biological Process: GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:1902042 negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:2001222 regulation of neuron migration
Cellular Component: GO:0000790 nuclear chromatin
GO:0005634 nucleus
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Descriptions from all associated GenBank mRNAs
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AK125343 - Homo sapiens cDNA FLJ43353 fis, clone NT2RP7009867. AY129025 - Homo sapiens clone FP7030 unknown mRNA. BC172245 - Synthetic construct Homo sapiens clone IMAGE:100068939, MGC:198950 scratch homolog 2, zinc finger protein (Drosophila) (SCRT2) mRNA, encodes complete protein.
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Other Names for This Gene
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Alternate Gene Symbols: FP7030, NM_033129, NP_149120, Q9NQ03, SCRT2_HUMAN UCSC ID: uc002wec.3 RefSeq Accession: NM_033129
Protein: Q9NQ03
(aka SCRT2_HUMAN or SCR2_HUMAN)
CCDS: CCDS13006.1
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Gene Model Information
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category:
| coding
| nonsense-mediated-decay:
| no
| RNA accession:
| NM_033129.3
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exon count:
| 2 | CDS single in 3' UTR:
| no
| RNA size:
| 3594 |
ORF size:
| 924 | CDS single in intron:
| no
| Alignment % ID:
| 100.00 |
txCdsPredict score:
| 1917.50 | frame shift in genome:
| no
| % Coverage:
| 99.53 |
has start codon:
| yes
| stop codon in genome:
| no
| # of Alignments:
| 1 |
has end codon:
| yes
| retained intron:
| no
| # AT/AC introns
| 0 |
selenocysteine:
| no
| end bleed into intron:
| 0 | # strange splices:
| 0 |
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for a detailed description of the fields of the table above.
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Methods, Credits, and Use Restrictions
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Click here
for details on how this gene model was made and data restrictions if any.
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