Description: Homo sapiens potassium voltage-gated channel, shaker-related subfamily, member 2 (KCNA2), transcript variant 1, mRNA. RefSeq Summary (NM_004974): Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member contains six membrane-spanning domains with a shaker-type repeat in the fourth segment. It belongs to the delayed rectifier class, members of which allow nerve cells to efficiently repolarize following an action potential. The coding region of this gene is intronless, and the gene is clustered with genes KCNA3 and KCNA10 on chromosome 1. [provided by RefSeq, Jul 2008]. Transcript (Including UTRs) Position: hg19 chr1:111,145,776-111,148,975 Size: 3,200 Total Exon Count: 3 Strand: - Coding Region Position: hg19 chr1:111,145,905-111,147,404 Size: 1,500 Coding Exon Count: 1
ID:KCNA2_HUMAN DESCRIPTION: RecName: Full=Potassium voltage-gated channel subfamily A member 2; AltName: Full=NGK1; AltName: Full=Voltage-gated K(+) channel HuKIV; AltName: Full=Voltage-gated potassium channel HBK5; AltName: Full=Voltage-gated potassium channel subunit Kv1.2; FUNCTION: Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. SUBUNIT: Heterotetramer of potassium channel proteins. Binds PDZ domains of DLG1, DLG2 and DLG4 (By similarity). SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein. DOMAIN: The N-terminus may be important in determining the rate of inactivation of the channel while the tail may play a role in modulation of channel activity and/or targeting of the channel to specific subcellular compartments. DOMAIN: The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position. PTM: Phosphorylated on tyrosine residues by activated PTK2B/PYK2; this regulates ion channel activity (By similarity). SIMILARITY: Belongs to the potassium channel family. A (Shaker) (TC 1.A.1.2) subfamily. Kv1.2/KCNA2 sub-subfamily.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P16389
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0006811 ion transport GO:0006813 potassium ion transport GO:0014059 regulation of dopamine secretion GO:0019228 neuronal action potential GO:0019233 sensory perception of pain GO:0021633 optic nerve structural organization GO:0034765 regulation of ion transmembrane transport GO:0045188 regulation of circadian sleep/wake cycle, non-REM sleep GO:0051259 protein oligomerization GO:0051260 protein homooligomerization GO:0055085 transmembrane transport GO:0071805 potassium ion transmembrane transport
BC043564 - Homo sapiens potassium voltage-gated channel, shaker-related subfamily, member 2, mRNA (cDNA clone MGC:50217 IMAGE:5212949), complete cds. KJ901536 - Synthetic construct Homo sapiens clone ccsbBroadEn_10930 KCNA2 gene, encodes complete protein. CU692176 - Synthetic construct Homo sapiens gateway clone IMAGE:100021364 5' read KCNA2 mRNA. AK290061 - Homo sapiens cDNA FLJ77031 complete cds, highly similar to Homo sapiens potassium voltage-gated channel, shaker-related subfamily, member 2 (KCNA2), mRNA. L02752 - Human potassium channel mRNA, complete cds. AB464665 - Synthetic construct DNA, clone: pF1KB9873, Homo sapiens KCNA2 gene for potassium voltage-gated channel, shaker-related subfamily, member 2, without stop codon, in Flexi system. JD349130 - Sequence 330154 from Patent EP1572962. JD345486 - Sequence 326510 from Patent EP1572962. JD197971 - Sequence 178995 from Patent EP1572962. JD337471 - Sequence 318495 from Patent EP1572962. JD521032 - Sequence 502056 from Patent EP1572962. JD202448 - Sequence 183472 from Patent EP1572962. JD421316 - Sequence 402340 from Patent EP1572962. JD208316 - Sequence 189340 from Patent EP1572962.
Biochemical and Signaling Pathways
BioCarta from NCI Cancer Genome Anatomy Project h_bArrestin-srcPathway - Roles of ¿-arrestin-dependent Recruitment of Src Kinases in GPCR Signaling h_bArrestinPathway - ¿-arrestins in GPCR Desensitization h_barr-mapkPathway - Role of ¿-arrestins in the activation and targeting of MAP kinases
Reactome (by CSHL, EBI, and GO)
Protein P16389 (Reactome details) participates in the following event(s):
US Server
