Description: Homo sapiens FERM and PDZ domain containing 4 (FRMPD4), mRNA. RefSeq Summary (NM_014728): This gene encodes a multi-domain (WW, PDZ, FERM) containing protein. Through its interaction with other proteins (such as PSD-95), it functions as a positive regulator of dendritic spine morphogenesis and density, and is required for the maintenance of excitatory synaptic transmission. [provided by RefSeq, Jan 2010]. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Transcript (Including UTRs) Position: hg19 chrX:12,156,585-12,742,642 Size: 586,058 Total Exon Count: 17 Strand: + Coding Region Position: hg19 chrX:12,157,091-12,738,652 Size: 581,562 Coding Exon Count: 17
ID:FRPD4_HUMAN DESCRIPTION: RecName: Full=FERM and PDZ domain-containing protein 4; AltName: Full=PDZ domain-containing protein 10; AltName: Full=PSD-95-interacting regulator of spine morphogenesis; Short=Preso; FUNCTION: Positive regulator of dendritic spine morphogenesis and density. Required for the maintenance of excitatory synaptic transmission. Binds phosphatidylinositol 4,5-bisphosphate. SUBUNIT: Interacts (via C-terminus) with DLG1, DLG2, DLG3 and DLG4/PSD95. Interacts (via N-terminus) with ARHGEF7; the interaction is mediated by the PDZ domain. SUBCELLULAR LOCATION: Cell projection, dendritic spine. DOMAIN: The FERM domain mediates the interaction with phosphatidylinositol 4,5-bisphosphate. SIMILARITY: Contains 1 FERM domain. SIMILARITY: Contains 1 PDZ (DHR) domain. SIMILARITY: Contains 1 WW domain.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF00373 - FERM central domain PF00595 - PDZ domain (Also known as DHR or GLGF)
SCOP Domains: 47031 - Second domain of FERM 50156 - PDZ domain-like 51045 - WW domain
ModBase Predicted Comparative 3D Structure on Q14CM0
Front
Top
Side
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.