Description: Homo sapiens phospholipase A2, group IVD (cytosolic) (PLA2G4D), mRNA. RefSeq Summary (NM_178034): The phospholipase A2 enzyme family, including PLA2G4D, catalyze the hydrolysis of glycerophospholipids at the sn-2 position and then liberate free fatty acids and lysophospholipids (Chiba et al., 2004 [PubMed 14709560]).[supplied by OMIM, Jun 2009]. Transcript (Including UTRs) Position: hg19 chr15:42,359,881-42,386,752 Size: 26,872 Total Exon Count: 20 Strand: - Coding Region Position: hg19 chr15:42,360,913-42,386,657 Size: 25,745 Coding Exon Count: 20
ID:PA24D_HUMAN DESCRIPTION: RecName: Full=Cytosolic phospholipase A2 delta; Short=cPLA2-delta; EC=3.1.1.4; AltName: Full=Phospholipase A2 group IVD; FUNCTION: Calcium-dependent phospholipase A2 that selectively hydrolyzes glycerophospholipids in the sn-2 position. Not arachidonic acid-specific but has linoleic acid-specific activity. May play a role in inflammation in psoriatic lesions. CATALYTIC ACTIVITY: Phosphatidylcholine + H(2)O = 1- acylglycerophosphocholine + a carboxylate. ENZYME REGULATION: Stimulated by cytosolic Ca(2+). SUBCELLULAR LOCATION: Cytoplasm, cytosol. Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side (By similarity). Note=Translocates to membrane vesicles in a calcium- dependent fashion. Translocates to perinuclear regions upon ionomycin stimulation (By similarity). TISSUE SPECIFICITY: Expressed in stratified squamous epithelia, such as those in skin and cervix, but not in other tissues. Strongly expressed in the upper spinous layer of the psoriatic epidermis, expressed weakly and discontinuously in atopic dermatitis and mycosis fungoides, and not detected in the epidermis of normal skin. DOMAIN: The N-terminal C2 domain associates with lipid membranes upon calcium binding. It modulates enzyme activity by presenting the active site to its substrate in response to elevations of cytosolic Ca(2+) (By similarity). SIMILARITY: Contains 1 C2 domain. SIMILARITY: Contains 1 PLA2c domain. SEQUENCE CAUTION: Sequence=AAH34571.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q86XP0
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
