ID:TBCD5_HUMAN DESCRIPTION: RecName: Full=TBC1 domain family member 5; FUNCTION: May act as a GTPase-activating protein for Rab family protein(s). INTERACTION: P54253:ATXN1; NbExp=2; IntAct=EBI-742381, EBI-930964; SIMILARITY: Contains 1 Rab-GAP TBC domain. SEQUENCE CAUTION: Sequence=BAA13201.2; Type=Erroneous initiation;
Walking Kathryn L Lunetta et al. BMC medical genetics 2007, Genetic correlates of longevity and selected age-related phenotypes: a genome-wide association study in the Framingham Study., BMC medical genetics.
[PubMed 17903295]
Longevity and aging traits are associated with SNPs on the Affymetrix 100K GeneChip. None of the associations achieved genome-wide significance. These data generate hypotheses and serve as a resource for replication as more genes and biologic pathways are proposed as contributing to longevity and healthy aging.
Walking Kathryn L Lunetta et al. BMC medical genetics 2007, Genetic correlates of longevity and selected age-related phenotypes: a genome-wide association study in the Framingham Study., BMC medical genetics.
[PubMed 17903295]
Longevity and aging traits are associated with SNPs on the Affymetrix 100K GeneChip. None of the associations achieved genome-wide significance. These data generate hypotheses and serve as a resource for replication as more genes and biologic pathways are proposed as contributing to longevity and healthy aging.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q92609
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0002092 positive regulation of receptor internalization GO:0006886 intracellular protein transport GO:0006914 autophagy GO:0015031 protein transport GO:0016236 macroautophagy GO:0031338 regulation of vesicle fusion GO:0042147 retrograde transport, endosome to Golgi GO:0042594 response to starvation GO:0090630 activation of GTPase activity GO:1902017 regulation of cilium assembly
US Server
