Description: Homo sapiens WD repeat domain 85 (DPH7), mRNA. RefSeq Summary (NM_138778): Diphthamide is a post-translationally modified histidine residue present in elongation factor 2, and is the target of diphtheria toxin. This gene encodes a protein that contains a WD-40 domain, and is thought to be involved in diphthamide biosynthesis. A similar protein in yeast functions as a methylesterase, converting methylated diphthine to diphthine, which can then undergo amidation to produce diphthamide. [provided by RefSeq, Oct 2016]. Transcript (Including UTRs) Position: hg19 chr9:140,458,939-140,473,387 Size: 14,449 Total Exon Count: 5 Strand: - Coding Region Position: hg19 chr9:140,459,186-140,468,730 Size: 9,545 Coding Exon Count: 2
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Mouse
Rat
Zebrafish
D. melanogaster
C. elegans
S. cerevisiae
No ortholog
No ortholog
No ortholog
No ortholog
No ortholog
No ortholog
Descriptions from all associated GenBank mRNAs
BC040173 - Homo sapiens WD repeat domain 85, mRNA (cDNA clone MGC:41963 IMAGE:4791980), complete cds. BC003123 - Homo sapiens WD repeat domain 85, mRNA (cDNA clone MGC:3209 IMAGE:3502107), complete cds. BC017335 - Homo sapiens WD repeat domain 85, mRNA (cDNA clone MGC:29782 IMAGE:4642600), complete cds. BC016349 - Homo sapiens WD repeat domain 85, mRNA (cDNA clone IMAGE:4071233), with apparent retained intron. AK075115 - Homo sapiens cDNA FLJ90634 fis, clone PLACE1003598, weakly similar to TRP-ASP REPEATS CONTAINING PROTEIN RBA-1. HQ448236 - Synthetic construct Homo sapiens clone IMAGE:100071637; CCSB007843_03 WD repeat domain 85 (WDR85) gene, encodes complete protein. KJ895195 - Synthetic construct Homo sapiens clone ccsbBroadEn_04589 WDR85 gene, encodes complete protein. KJ904948 - Synthetic construct Homo sapiens clone ccsbBroadEn_14342 WDR85 gene, encodes complete protein. AK310226 - Homo sapiens cDNA, FLJ17268. CU675946 - Synthetic construct Homo sapiens gateway clone IMAGE:100017300 5' read WDR85 mRNA. AK308998 - Homo sapiens cDNA, FLJ99039. AK307180 - Homo sapiens cDNA, FLJ97128. AK310987 - Homo sapiens cDNA, FLJ18029. JD055041 - Sequence 36065 from Patent EP1572962. JD336050 - Sequence 317074 from Patent EP1572962.