Description: Homo sapiens cyclin-dependent kinase 1 (CDK1), transcript variant 1, mRNA. RefSeq Summary (NM_001786): The protein encoded by this gene is a member of the Ser/Thr protein kinase family. This protein is a catalytic subunit of the highly conserved protein kinase complex known as M-phase promoting factor (MPF), which is essential for G1/S and G2/M phase transitions of eukaryotic cell cycle. Mitotic cyclins stably associate with this protein and function as regulatory subunits. The kinase activity of this protein is controlled by cyclin accumulation and destruction through the cell cycle. The phosphorylation and dephosphorylation of this protein also play important regulatory roles in cell cycle control. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]. Transcript (Including UTRs) Position: hg19 chr10:62,538,212-62,554,610 Size: 16,399 Total Exon Count: 8 Strand: + Coding Region Position: hg19 chr10:62,539,924-62,553,733 Size: 13,810 Coding Exon Count: 7
ID:CDK1_HUMAN DESCRIPTION: RecName: Full=Cyclin-dependent kinase 1; Short=CDK1; EC=2.7.11.22; EC=2.7.11.23; AltName: Full=Cell division control protein 2 homolog; AltName: Full=Cell division protein kinase 1; AltName: Full=p34 protein kinase; FUNCTION: Plays a key role in the control of the eukaryotic cell cycle by modulating the centrosome cycle as well as mitotic onset; promotes G2-M transition, and regulates G1 progress and G1-S transition via association with multiple interphase cyclins. Required in higher cells for entry into S-phase and mitosis. Phosphorylates PARVA/actopaxin, APC, AMPH, APC, BARD1, Bcl- xL/BCL2L1, BRCA2, CALD1, CASP8, CDC7, CDC20, CDC25A, CDC25C, CC2D1A, CSNK2 proteins/CKII, FZR1/CDH1, CDK7, CEBPB, CHAMP1, DMD/dystrophin, EEF1 proteins/EF-1, EZH2, KIF11/EG5, EGFR, FANCG, FOS, GFAP, GOLGA2/GM130, GRASP1, UBE2A/hHR6A, HIST1H1 proteins/histone H1, HMGA1, HIVEP3/KRC, LMNA, LMNB, LMNC, LBR, LATS1, MAP1B, MAP4, MARCKS, MCM2, MCM4, MKLP1, MYB, NEFH, NFIC, NPC/nuclear pore complex, PITPNM1/NIR2, NPM1, NCL, NUCKS1, NPM1/numatrin, ORC1, PRKAR2A, EEF1E1/p18, EIF3F/p47, p53/TP53, NONO/p54NRB, PAPOLA, PLEC/plectin, RB1, UL40/R2, RAB4A, RAP1GAP, RCC1, RPS6KB1/S6K1, KHDRBS1/SAM68, ESPL1, SKI, BIRC5/survivin, STIP1, TEX14, beta-tubulins, MAPT/TAU, NEDD1, VIM/vimentin, TK1, FOXO1, RUNX1/AML1 and RUNX2. CDK1/CDC2-cyclin-B controls pronuclear union in interphase fertilized eggs. Essential for early stages of embryonic development. During G2 and early mitosis, CDC25A/B/C-mediated dephosphorylation activates CDK1/cyclin complexes which phosphorylate several substrates that trigger at least centrosome separation, Golgi dynamics, nuclear envelope breakdown and chromosome condensation. Once chromosomes are condensed and aligned at the metaphase plate, CDK1 activity is switched off by WEE1- and PKMYT1-mediated phosphorylation to allow sister chromatid separation, chromosome decondensation, reformation of the nuclear envelope and cytokinesis. Inactivated by PKR/EIF2AK2- and WEE1-mediated phosphorylation upon DNA damage to stop cell cycle and genome replication at the G2 checkpoint thus facilitating DNA repair. Reactivated after successful DNA repair through WIP1-dependent signaling leading to CDC25A/B/C- mediated dephosphorylation and restoring cell cycle progression. In proliferating cells, CDK1-mediated FOXO1 phosphorylation at the G2-M phase represses FOXO1 interaction with 14-3-3 proteins and thereby promotes FOXO1 nuclear accumulation and transcription factor activity, leading to cell death of postmitotic neurons. The phosphorylation of beta-tubulins regulates microtubule dynamics during mitosis. NEDD1 phosphorylation promotes PLK1-mediated NEDD1 phosphorylation and subsequent targeting of the gamma-tubulin ring complex (gTuRC) to the centrosome, an important step for spindle formation. In addition, CC2D1A phosphorylation regulates CC2D1A spindle pole localization and association with SCC1/RAD21 and centriole cohesion during mitosis. The phosphorylation of Bcl- xL/BCL2L1 after prolongated G2 arrest upon DNA damage triggers apoptosis. In contrast, CASP8 phosphorylation during mitosis prevents its activation by proteolysis and subsequent apoptosis. This phosphorylation occurs in cancer cell lines, as well as in primary breast tissues and lymphocytes. EZH2 phosphorylation promotes H3K27me3 maintenance and epigenetic gene silencing. CALD1 phosphorylation promotes Schwann cell migration during peripheral nerve regeneration. CATALYTIC ACTIVITY: ATP + a protein = ADP + a phosphoprotein. CATALYTIC ACTIVITY: ATP + [DNA-directed RNA polymerase] = ADP + [DNA-directed RNA polymerase] phosphate. ENZYME REGULATION: Phosphorylation at Thr-14 or Tyr-15 inactivates the enzyme, while phosphorylation at Thr-161 activates it. Activated through a multistep process; binding to cyclin-B is required for relocation of cyclin-kinase complexes to the nucleus, activated by CAK/CDK7-mediated phosphorylation on Thr-161, and CDC25-mediated dephosphorylation of inhibitory phosphorylation on Thr-14 and Tyr-15. Inhibited by flavopiridol and derivatives, pyrimidine derivatives, pyridine derivatives, purine derivatives, staurosporine, paullones, oxoindoles, indazole analogs, indolin-2- ones, pyrazolo[3,4-b]pyridines, imidazo[1,2-a]pyridine (AZ703), thiazolinone analogs(RO-3306), thiazol urea, macrocyclic quinoxalin-2-one, pyrrolo[2,3-a]carbazole, pyrazolo[1,5-a]-1,3,5- triazine, pyrazolo[1,5-a]pyrimidine (Dinaciclib, SCH 727965), 2- (1-ethyl-2-hydroxyethylamino)-6-benzylamino-9-isopropylpurine (roscovitine), olomoucine, AG-024322, AT-7519, P276-00, R547/Ro- 4584820 and SNS-032/BMS-387032. Repressed by the CDK inhibitors CDKN1A/p21 and CDKN1B/p27 during the G1 phase and by CDKN1A/p21 at the G1-S checkpoint upon DNA damage. Transient activation by rapid and transient dephosphorylation at Tyr-15 triggered by TGFB1. SUBUNIT: Forms a stable but non-covalent complex with a regulatory subunit and with a cyclin. Interacts with cyclins-B (CCNB1, CCNB2 and CCNB3) to form a serine/threonine kinase holoenzyme complex also known as maturation promoting factor (MPF). The cyclin subunit imparts substrate specificity to the complex. Can also form CDK1-cylin-D and CDK1-cyclin-E complexes that phosphorylate RB1 in vitro. Binds to RB1 and other transcription factors such as FOXO1 and RUNX2. Promotes G2-M transition when in complex with a cyclin-B. Interacts with DLGAP5. Binds to the CDK inhibitors CDKN1A/p21 and CDKN1B/p27. Isoform 2 is unable to complex with cyclin-B1 and also fails to bind to CDKN1A/p21. Interacts with catalytically active CCNB1 and RALBP1 during mitosis to form an endocytotic complex during interphase. Associates with cyclins-A and B1 during S-phase in regenerating hepatocytes. Interacts with FANCC. Interacts with CEP63; this interaction recruits CDK1 to centrosomes. INTERACTION: O15392:BIRC5; NbExp=6; IntAct=EBI-444308, EBI-518823; P14635:CCNB1; NbExp=4; IntAct=EBI-444308, EBI-495332; P30307:CDC25C; NbExp=2; IntAct=EBI-444308, EBI-974439; Q12778:FOXO1; NbExp=5; IntAct=EBI-444308, EBI-1108782; O95835:LATS1; NbExp=2; IntAct=EBI-444308, EBI-444209; Q99640:PKMYT1; NbExp=2; IntAct=EBI-444308, EBI-495308; SUBCELLULAR LOCATION: Nucleus. Cytoplasm. Mitochondrion. Cytoplasm, cytoskeleton, centrosome. Note=Cytoplasmic during the interphase. Reversibly translocated from cytoplasm to nucleus when phosphorylated before G2-M transition when associated with cyclin- B1. Accumulates in mitochondria in G2-arrested cells upon DNA- damage. TISSUE SPECIFICITY: Isoform 2 is found in breast cancer tissues. INDUCTION: Follows a cyclic expression; during interphase, accumulates gradually following G1, S to reach a critical threshold at the end of G2, which promotes self-activation and triggers onset of mitosis. Induced transiently by TGFB1 at an early phase of TGFB1-mediated apoptosis, but later repressed. Triggered by CKS1B during mitotic entry in breast cancer cells. Down-regulated under genotoxic stresses triggered by PKR/EIF2AK2- mediated phosphorylation. PTM: Phosphorylation at Thr-161 by CAK/CDK7 activates kinase activity. Phosphorylation at Thr-14 and Tyr-15 by PKMYT1 prevents nuclear translocation. Phosphorylation at Tyr-15 by WEE1 and WEE2 inhibits the protein kinase activity and acts as a negative regulator of entry into mitosis (G2 to M transition). Phosphorylation by PKMYT1 and WEE1 takes place during mitosis to keep CDK1-cyclin-B complexes inactive until the end of G2. By the end of G2, PKMYT1 and WEE1 are inactivated, but CDC25A and CDC25B are activated. Dephosphorylation by active CDC25A and CDC25B at Thr-14 and Tyr-15, leads to CDK1 activation at the G2-M transition. Phosphorylation at Tyr-15 by WEE2 during oogenesis is required to maintain meiotic arrest in oocytes during the germinal vesicle (GV) stage, a long period of quiescence at dictyate prophase I, leading to prevent meiotic reentry. Phosphorylation by WEE2 is also required for metaphase II exit during egg activation to ensure exit from meiosis in oocytes and promote pronuclear formation. Phosphorylated at Tyr-4 by PKR/EIF2AK2 upon genotoxic stress. This phosphorylation triggers CDK1 polyubiquitination and subsequent proteolysis, thus leading to G2 arrest. In response to UV irradiation, phosphorylation at Tyr-15 by PRKCD activates the G2/M DNA damage checkpoint. PTM: Polyubiquitinated upon genotoxic stress. MISCELLANEOUS: As a key regulator of the cell cycle, CDK1 is a potent therapeutic target for inhibitors in cancer treatment (PubMed:21517772). SIMILARITY: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily. SIMILARITY: Contains 1 protein kinase domain. SEQUENCE CAUTION: Sequence=EAW54204.1; Type=Erroneous gene model prediction; WEB RESOURCE: Name=NIEHS-SNPs; URL="http://egp.gs.washington.edu/data/cdc2/";
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P06493
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0000086 G2/M transition of mitotic cell cycle GO:0000187 activation of MAPK activity GO:0000226 microtubule cytoskeleton organization GO:0000278 mitotic cell cycle GO:0006260 DNA replication GO:0006281 DNA repair GO:0006468 protein phosphorylation GO:0006915 apoptotic process GO:0006977 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest GO:0007049 cell cycle GO:0007077 mitotic nuclear envelope disassembly GO:0007095 mitotic G2 DNA damage checkpoint GO:0007098 centrosome cycle GO:0007344 pronuclear fusion GO:0007569 cell aging GO:0008283 cell proliferation GO:0009636 response to toxic substance GO:0010243 response to organonitrogen compound GO:0010389 regulation of G2/M transition of mitotic cell cycle GO:0010468 regulation of gene expression GO:0010628 positive regulation of gene expression GO:0010971 positive regulation of G2/M transition of mitotic cell cycle GO:0014038 regulation of Schwann cell differentiation GO:0014070 response to organic cyclic compound GO:0014075 response to amine GO:0014823 response to activity GO:0016310 phosphorylation GO:0016477 cell migration GO:0016572 histone phosphorylation GO:0016579 protein deubiquitination GO:0018105 peptidyl-serine phosphorylation GO:0018107 peptidyl-threonine phosphorylation GO:0030261 chromosome condensation GO:0030855 epithelial cell differentiation GO:0031100 animal organ regeneration GO:0031145 anaphase-promoting complex-dependent catabolic process GO:0033160 positive regulation of protein import into nucleus, translocation GO:0034501 protein localization to kinetochore GO:0042493 response to drug GO:0042542 response to hydrogen peroxide GO:0043066 negative regulation of apoptotic process GO:0044772 mitotic cell cycle phase transition GO:0045471 response to ethanol GO:0045740 positive regulation of DNA replication GO:0045931 positive regulation of mitotic cell cycle GO:0045995 regulation of embryonic development GO:0046686 response to cadmium ion GO:0046688 response to copper ion GO:0046718 viral entry into host cell GO:0048678 response to axon injury GO:0051301 cell division GO:0051445 regulation of meiotic cell cycle GO:0055015 ventricular cardiac muscle cell development GO:0060045 positive regulation of cardiac muscle cell proliferation GO:0065003 macromolecular complex assembly GO:0070301 cellular response to hydrogen peroxide GO:0090166 Golgi disassembly GO:0097711 ciliary basal body docking GO:1900182 positive regulation of protein localization to nucleus GO:1905448 positive regulation of mitochondrial ATP synthesis coupled electron transport
AK295741 - Homo sapiens cDNA FLJ50170 complete cds, highly similar to Cell division control protein 2 homolog (EC 2.7.11.22). HW061216 - JP 2012529430-A/91: METHODS FOR TREATING CHRONIC KIDNEY DISEASE. JB252024 - Sequence 91 from Patent EP2440214. LP764923 - Sequence 91 from Patent EP3276004. X05360 - Human CDC2 gene involved in cell cycle control. Y00272 - Human cell cycle control gene CDC2. JD038702 - Sequence 19726 from Patent EP1572962. CR933728 - Homo sapiens mRNA; cDNA DKFZp686L20222 (from clone DKFZp686L20222). BC107750 - Homo sapiens cell division cycle 2, G1 to S and G2 to M, mRNA (cDNA clone MGC:111195 IMAGE:6710672), complete cds. AK291939 - Homo sapiens cDNA FLJ76624 complete cds, highly similar to Homo sapiens cell division cycle 2, G1 to S and G2 to M (CDC2), transcript variant 1, mRNA. HW061218 - JP 2012529430-A/93: METHODS FOR TREATING CHRONIC KIDNEY DISEASE. JB252026 - Sequence 93 from Patent EP2440214. LP764925 - Sequence 93 from Patent EP3276004. D88357 - Homo sapiens mRNA for CDC2 delta T, complete cds. HW061217 - JP 2012529430-A/92: METHODS FOR TREATING CHRONIC KIDNEY DISEASE. JB252025 - Sequence 92 from Patent EP2440214. LP764924 - Sequence 92 from Patent EP3276004. BC014563 - Homo sapiens cell division cycle 2, G1 to S and G2 to M, mRNA (cDNA clone MGC:1785 IMAGE:2967728), complete cds. JD307841 - Sequence 288865 from Patent EP1572962. KJ890876 - Synthetic construct Homo sapiens clone ccsbBroadEn_00270 CDK1 gene, encodes complete protein. KJ905162 - Synthetic construct Homo sapiens clone ccsbBroadEn_14569 CDK1 gene, encodes complete protein. AB587332 - Synthetic construct DNA, clone: pF1KB8468, Homo sapiens CDC2 gene for cell division cycle 2, G1 to S and G2 to M, without stop codon, in Flexi system. AM392583 - Synthetic construct Homo sapiens clone IMAGE:100002752 for hypothetical protein (CDC2 gene). AM393047 - Synthetic construct Homo sapiens clone IMAGE:100002751 for hypothetical protein (CDC2 gene). AM393287 - Synthetic construct Homo sapiens clone IMAGE:100003002 for hypothetical protein (CDC2 gene). AM393726 - Synthetic construct Homo sapiens clone IMAGE:100003001 for hypothetical protein (CDC2 gene). BT007004 - Homo sapiens cell division cycle 2, G1 to S and G2 to M mRNA, complete cds. JD024699 - Sequence 5723 from Patent EP1572962. LF343339 - JP 2014500723-A/150842: Polycomb-Associated Non-Coding RNAs. JD035802 - Sequence 16826 from Patent EP1572962. AK027271 - Homo sapiens cDNA FLJ14365 fis, clone HEMBA1001019. JD281245 - Sequence 262269 from Patent EP1572962. MA578916 - JP 2018138019-A/150842: Polycomb-Associated Non-Coding RNAs.
Biochemical and Signaling Pathways
KEGG - Kyoto Encyclopedia of Genes and Genomes hsa04110 - Cell cycle hsa04114 - Oocyte meiosis hsa04115 - p53 signaling pathway hsa04540 - Gap junction hsa04914 - Progesterone-mediated oocyte maturation
BioCarta from NCI Cancer Genome Anatomy Project h_g2Pathway - Cell Cycle: G2/M Checkpoint h_sam68Pathway - Regulation of Splicing through Sam68 h_mPRPathway - How Progesterone Initiates the Oocyte Maturation h_ptc1Pathway - Sonic Hedgehog (SHH) Receptor Ptc1 Regulates cell cycle h_akap95Pathway - AKAP95 role in mitosis and chromosome dynamics h_cellcyclePathway - Cyclins and Cell Cycle Regulation h_srcRPTPPathway - Activation of Src by Protein-tyrosine phosphatase alpha h_stathminPathway - Stathmin and breast cancer resistance to antimicrotubule agents h_cdc25Pathway - cdc25 and chk1 Regulatory Pathway in response to DNA damage h_rbPathway - RB Tumor Suppressor/Checkpoint Signaling in response to DNA damage h_g1Pathway - Cell Cycle: G1/S Check Point h_akapCentrosomePathway - Protein Kinase A at the Centrosome h_EfpPathway - Estrogen-responsive protein Efp controls cell cycle and breast tumors growth
Reactome (by CSHL, EBI, and GO)
Protein P06493 (Reactome details) participates in the following event(s):
R-HSA-170057 Formation of Cyclin B:Cdc2 complexes R-HSA-170084 Formation of Cyclin A:Cdc2 complexes R-HSA-113638 Association of Cyclin B/Cdk1 with replicative origin inhibits pre-RC formation R-HSA-170126 Phosphorylation of Cyclin B1 in the CRS domain R-HSA-174120 Association of Cyclin B:Cdc2 with Cdc20:APC/C complex R-HSA-170131 Translocation of CRS phosphorylated Cyclin B1:Cdc2 complexes R-HSA-174171 Association of Cyclin A with the APC/C R-HSA-112342 Inactivation of MAP2K1 by CDK1 R-HSA-170076 CAK-mediated phosphorylation of Cyclin B1:Cdc2 complexes R-HSA-170087 CAK-mediated phosphorylation of Cyclin A:Cdc2 complexes R-HSA-170088 Translocation of Cyclin A:phospho-Cdc2 (Thr 14) to the nucleus R-HSA-170055 Myt-1 mediated phosphorylation of Cyclin B:Cdc2 complexes R-HSA-170116 Myt-1 mediated phosphorylation of Cyclin A:Cdc2 R-HSA-170158 Dephosphorylation of nuclear Cyclin A:phospho-Cdc2 complexes R-HSA-170153 Dephosphorylation of nuclear Cyclin B1:phospho-Cdc2 (Thr 14, Tyr15) complexes by Cdc25 phosphatases R-HSA-5692755 CDK1 phosphorylates MAPK6 R-HSA-170072 Translocation of Cyclin B1:phospho-Cdc2 to the cytoplasm R-HSA-170070 Wee1-mediated phosphorylation of Cyclin B1:phospho-Cdc2 complexes R-HSA-170156 Wee1-mediated phosphorylation of Cyclin A:phospho-Cdc2 complexes R-HSA-380272 Plk1-mediated phosphorylation of Nlp R-HSA-380283 Recruitment of additional gamma tubulin/ gamma TuRC to the centrosome R-HSA-380294 Loss of C-Nap-1 from centrosomes R-HSA-380311 Recruitment of Plk1 to centrosomes R-HSA-380455 Recruitment of CDK11p58 to the centrosomes R-HSA-380303 Dissociation of Phospho-Nlp from the centrosome R-HSA-5626220 C2CD3 binds the mother centriole R-HSA-6803875 SFN dimer binds CDK1 and CCNB1 R-HSA-8940100 CDK1 phosphorylates VCPIP1 R-HSA-170161 Dephosphorylation of cytoplasmic Cyclin B1/B2:phospho-Cdc2 (Thr 14, Tyr 15) complexes by CDC25B R-HSA-174227 Ubiquitination of Cyclin B by phospho-APC/C:Cdc20 complex R-HSA-170044 Translocation of Cyclin B1:phospho-Cdc2 complexes to the nucleus R-HSA-174104 Ubiquitination of Cyclin A by APC/C:Cdc20 complex R-HSA-69754 Phosphorylation of proteins involved in G2/M transition by active Cyclin A1:Cdc2 complexes R-HSA-69756 Phosphorylation of proteins involved in G2/M transition by active Cyclin A2:Cdc2 complexes R-HSA-174122 Phosphorylation of the Emi1 DSGxxS degron by Cyclin B:Cdc2 R-HSA-174132 Free APC/C phosphorylated by Cyclin B:Cdc2 R-HSA-174251 Phosphorylation of Cdh1 by Cyclin B1:Cdc2 R-HSA-380278 CCNB1:p-T160-CDK1 phosphorylates NUMA1 R-HSA-2245218 CDK1 phosphorylates PHF8 R-HSA-2294600 CDK1 phosphorylates condensin II subunit NCAPD3 R-HSA-2430533 CDK1 phosphorylates MASTL R-NUL-2434198 CDK1 phosphorylates Mastl R-HSA-5195402 CDK1 phosphorylates LPIN R-HSA-5244669 CDK1 phosphorylates lamins and facilitates depolymerization of lamin filaments R-HSA-9009282 CDK1 phosphorylates RUNX2 R-HSA-380508 Translocation of NuMA to the centrosomes R-HSA-2574845 AJUBA binds centrosome-associated AURKA R-HSA-8853405 TPX2 binds AURKA at centrosomes R-HSA-3000319 BORA binds PLK1 and AURKA R-HSA-2574840 AJUBA facilitates AURKA autophosphorylation R-HSA-3000310 AURKA phosphorylates PLK1 R-HSA-5626223 C2CD3 and OFD1 recruit 5 distal appendage proteins to the centriole R-HSA-5626681 Recruitment of transition zone proteins R-HSA-5626227 CP110 and CEP97 dissociate from the centriole R-HSA-2172183 Phosphorylation of GORASP1, GOLGA2 and RAB1A by CDK1:CCNB R-NUL-2422970 Phosphorylation of Gorasp1, Golga2 and RAB1A by CDK1:CCNB R-HSA-2468287 CDK1 phosphorylates CDCA5 (Sororin) at centromeres R-HSA-2468293 CDK1 phosphorylates CDCA5 (Sororin) at chromosomal arms R-HSA-2514854 CDK1 phosphorylates condensin I R-HSA-2984220 CDK1:CCNB phosphorylates NEK9 R-HSA-2990882 CDK1 phosphorylates NUP98 R-HSA-4086410 CDK1 phosphorylates BORA R-HSA-6793661 (CDK1,CDK2):CCNA phosphorylates MDM2 at T218 R-HSA-4088024 CCNA:CDK1/2 complexes and CCNB1:CDK1 complexes phosphorylate FOXM1 R-HSA-380316 Association of NuMA with microtubules R-HSA-8853419 TPX2 promotes AURKA autophosphorylation R-HSA-5626228 The distal appendage proteins recruit TTBK2 R-HSA-5638009 CEP164 recruits RAB3IP-carrying Golgi-derived vesicles to the basal body R-HSA-8852306 Mitotic phosphorylation-induced dissociation of GTSE1 from microtubule plus ends R-HSA-5626699 MARK4 binds ODF2 in the centriole R-HSA-5617816 RAB3IP stimulates nucleotide exchange on RAB8A R-HSA-539107 Activation of E2F1 target genes at G1/S R-HSA-1362300 Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 R-HSA-174048 APC/C:Cdc20 mediated degradation of Cyclin B R-HSA-174184 Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-HSA-69273 Cyclin A/B1/B2 associated events during G2/M transition R-HSA-113507 E2F-enabled inhibition of pre-replication complex formation R-HSA-69205 G1/S-Specific Transcription R-HSA-1538133 G0 and Early G1 R-HSA-176409 APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-179419 APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint R-HSA-110056 MAPK3 (ERK1) activation R-HSA-69478 G2/M DNA replication checkpoint R-HSA-5687128 MAPK6/MAPK4 signaling R-HSA-75035 Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex R-HSA-380259 Loss of Nlp from mitotic centrosomes R-HSA-380270 Recruitment of mitotic centrosome proteins and complexes R-HSA-380284 Loss of proteins required for interphase microtubule organization from the centrosome R-HSA-5620912 Anchoring of the basal body to the plasma membrane R-HSA-6804114 TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest R-HSA-69275 G2/M Transition R-HSA-5689896 Ovarian tumor domain proteases R-HSA-113510 E2F mediated regulation of DNA replication R-HSA-69206 G1/S Transition R-HSA-453279 Mitotic G1-G1/S phases R-HSA-176814 Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-112409 RAF-independent MAPK1/3 activation R-HSA-69481 G2/M Checkpoints R-HSA-170145 Phosphorylation of proteins involved in the G2/M transition by Cyclin A:Cdc2 complexes R-HSA-176417 Phosphorylation of Emi1 R-HSA-176412 Phosphorylation of the APC/C R-HSA-176408 Regulation of APC/C activators between G1/S and early anaphase R-HSA-68875 Mitotic Prophase R-HSA-2299718 Condensation of Prophase Chromosomes R-HSA-2465910 MASTL Facilitates Mitotic Progression R-HSA-4419969 Depolymerisation of the Nuclear Lamina R-HSA-8878166 Transcriptional regulation by RUNX2 R-HSA-5683057 MAPK family signaling cascades R-HSA-69473 G2/M DNA damage checkpoint R-HSA-380320 Recruitment of NuMA to mitotic centrosomes R-HSA-2565942 Regulation of PLK1 Activity at G2/M Transition R-HSA-8854518 AURKA Activation by TPX2 R-HSA-380287 Centrosome maturation R-HSA-5617833 Cilium Assembly R-HSA-6791312 TP53 Regulates Transcription of Cell Cycle Genes R-HSA-453274 Mitotic G2-G2/M phases R-HSA-5688426 Deubiquitination R-HSA-69278 Cell Cycle (Mitotic) R-HSA-162658 Golgi Cisternae Pericentriolar Stack Reorganization R-HSA-2500257 Resolution of Sister Chromatid Cohesion R-HSA-2514853 Condensation of Prometaphase Chromosomes R-HSA-2980767 Activation of NIMA Kinases NEK9, NEK6, NEK7 R-HSA-3301854 Nuclear Pore Complex (NPC) Disassembly R-HSA-174143 APC/C-mediated degradation of cell cycle proteins R-HSA-5684996 MAPK1/MAPK3 signaling R-HSA-69620 Cell Cycle Checkpoints R-HSA-6804757 Regulation of TP53 Degradation R-HSA-68886 M Phase R-HSA-2980766 Nuclear Envelope Breakdown R-HSA-212436 Generic Transcription Pathway R-HSA-162582 Signal Transduction R-HSA-68877 Mitotic Prometaphase R-HSA-1852241 Organelle biogenesis and maintenance R-HSA-3700989 Transcriptional Regulation by TP53 R-HSA-597592 Post-translational protein modification R-HSA-1640170 Cell Cycle R-HSA-8852276 The role of GTSE1 in G2/M progression after G2 checkpoint R-HSA-453276 Regulation of mitotic cell cycle R-HSA-6806003 Regulation of TP53 Expression and Degradation R-HSA-73857 RNA Polymerase II Transcription R-HSA-392499 Metabolism of proteins R-HSA-5633007 Regulation of TP53 Activity R-HSA-74160 Gene expression (Transcription)
US Server
