Description: Homo sapiens CCR4-NOT transcription complex, subunit 2 (CNOT2), transcript variant 2, mRNA. RefSeq Summary (NM_014515): This gene encodes a subunit of the multi-component CCR4-NOT complex. The CCR4-NOT complex regulates mRNA synthesis and degradation and is also thought to be involved in mRNA splicing, transport and localization. The encoded protein interacts with histone deacetylases and functions as a repressor of polymerase II transcription. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Dec 2010]. Transcript (Including UTRs) Position: hg19 chr12:70,636,774-70,748,773 Size: 112,000 Total Exon Count: 16 Strand: + Coding Region Position: hg19 chr12:70,672,007-70,747,695 Size: 75,689 Coding Exon Count: 15
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9NZN8
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0001104 RNA polymerase II transcription cofactor activity GO:0001226 RNA polymerase II transcription corepressor binding GO:0005515 protein binding GO:0004535 poly(A)-specific ribonuclease activity
Biological Process: GO:0000122 negative regulation of transcription from RNA polymerase II promoter GO:0000288 nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay GO:0000289 nuclear-transcribed mRNA poly(A) tail shortening GO:0001829 trophectodermal cell differentiation GO:0006351 transcription, DNA-templated GO:0006355 regulation of transcription, DNA-templated GO:0006357 regulation of transcription from RNA polymerase II promoter GO:0006417 regulation of translation GO:0006977 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest GO:0007275 multicellular organism development GO:0010606 positive regulation of cytoplasmic mRNA processing body assembly GO:0017148 negative regulation of translation GO:0031047 gene silencing by RNA GO:0033147 negative regulation of intracellular estrogen receptor signaling pathway GO:0090503 RNA phosphodiester bond hydrolysis, exonucleolytic GO:2000036 regulation of stem cell population maintenance
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Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
