Description: Homo sapiens UFM1-specific peptidase 2 (UFSP2), transcript variant 1, mRNA. RefSeq Summary (NM_018359): This gene encodes a highly conserved cysteine protease. The protein cleaves two C-terminal residues from ubiquitin-fold modifier 1, a ubiquitin-like post-translational modifier protein. Activation of ubiquitin-fold modifier 1 by the encoded protein exposes a C-terminal glycine residue that allows interaction with other proteins and transfer to its target protein. An allelic variant of this gene has been associated with Beukes hip dysplasia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2016]. Transcript (Including UTRs) Position: hg19 chr4:186,320,694-186,347,139 Size: 26,446 Total Exon Count: 12 Strand: - Coding Region Position: hg19 chr4:186,321,546-186,347,022 Size: 25,477 Coding Exon Count: 12
ID:UFSP2_HUMAN DESCRIPTION: RecName: Full=Ufm1-specific protease 2; Short=UfSP2; EC=3.4.22.-; FUNCTION: Thiol protease which recognizes and hydrolyzes the peptide bond at the C-terminal Gly of UFM1, an ubiquitin-like modifier protein bound to a number of target proteins. Does not hydrolyze SUMO1 or ISG15 ubiquitin-like proteins (By similarity). SUBUNIT: Interacts with DDRGK1 (By similarity). SUBCELLULAR LOCATION: Cytoplasm (By similarity). Endoplasmic reticulum (By similarity). Nucleus (By similarity). SIMILARITY: Belongs to the peptidase C78 family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9NUQ7
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
