Description: Homo sapiens RAB40A, member RAS oncogene family-like (RAB40AL), mRNA. RefSeq Summary (NM_001031834): This gene encodes a member of the Rab40 subfamily of Rab small GTP-binding proteins that contains a C-terminal suppressors of cytokine signaling box. Disruptions in this gene are associated with Duchenne muscular dystrophy. [provided by RefSeq, Apr 2010]. Transcript (Including UTRs) Position: hg19 chrX:102,192,200-102,193,228 Size: 1,029 Total Exon Count: 1 Strand: + Coding Region Position: hg19 chrX:102,192,247-102,193,083 Size: 837 Coding Exon Count: 1
ID:RB40L_HUMAN DESCRIPTION: RecName: Full=Ras-related protein Rab-40A-like; AltName: Full=Ras-like GTPase; FUNCTION: May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). PATHWAY: Protein modification; protein ubiquitination. SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor; Cytoplasmic side (Potential). Mitochondrion. TISSUE SPECIFICITY: Expressed in brain, heart, skeletal muscle, kidney and liver. Highest expression in brain. DOMAIN: The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin ligase complexes (By similarity). SIMILARITY: Belongs to the small GTPase superfamily. Rab family. SIMILARITY: Contains 1 SOCS box domain.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P0C0E4
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0016567 protein ubiquitination GO:0035556 intracellular signal transduction GO:0072659 protein localization to plasma membrane GO:0006904 vesicle docking involved in exocytosis GO:0009306 protein secretion GO:0017157 regulation of exocytosis
US Server
