Human Gene GPR89C (uc001eou.4)
  Description: Homo sapiens G protein-coupled receptor 89C (GPR89C), mRNA.
Transcript (Including UTRs)
   Position: hg19 chr1:145,883,868-145,924,049 Size: 40,182 Total Exon Count: 9 Strand: +
Coding Region
   Position: hg19 chr1:145,883,868-145,923,443 Size: 39,576 Coding Exon Count: 9 

Page IndexSequence and LinksUniProtKB CommentsPrimersGene AllelesRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesmRNA DescriptionsOther Names
Model InformationMethods
Data last updated at UCSC: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr1:145,883,868-145,924,049)mRNA (may differ from genome)Protein (320 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
BioGPSEnsemblExonPrimerGeneCardsGeneNetworkH-INV
HGNCHPRDLynxMGIneXtProtPubMed
UniProtKBWikipedia

-  Comments and Description Text from UniProtKB
  ID: GPHRC_HUMAN
DESCRIPTION: RecName: Full=Putative Golgi pH regulator C; AltName: Full=Protein GPR89C;
SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein (Potential).
SIMILARITY: Belongs to the Golgi pH regulator (TC 1.A.38) family.
CAUTION: Could be the product of a pseudogene.
SEQUENCE CAUTION: Sequence=CAI17085.1; Type=Erroneous gene model prediction;

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 0.30 RPKM in Kidney - Cortex
Total median expression: 4.78 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
3' UTR -175.44606-0.290 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR025969 - ABA_GPCR_dom
IPR022535 - Golgi_pH-regulator_cons_dom
IPR015672 - GPCR89-rel

Pfam Domains:
PF12430 - Abscisic acid G-protein coupled receptor
PF12537 - The Golgi pH Regulator (GPHR) Family N-terminal

ModBase Predicted Comparative 3D Structure on A6NKF9
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
      
      
      

-  Descriptions from all associated GenBank mRNAs
  LP895152 - Sequence 16 from Patent EP3253886.
AF151035 - Homo sapiens HSPC201 mRNA, complete cds.
JD225141 - Sequence 206165 from Patent EP1572962.
JD323430 - Sequence 304454 from Patent EP1572962.
JD377575 - Sequence 358599 from Patent EP1572962.
JD111077 - Sequence 92101 from Patent EP1572962.
JD064920 - Sequence 45944 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: A6NKF9, GPHRC, GPHRC_HUMAN, NM_001097616, NP_001091085
UCSC ID: uc001eou.4
RefSeq Accession: NM_001097616
Protein: A6NKF9 (aka GPHRC_HUMAN)

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: NM_001097616.1
exon count: 9CDS single in 3' UTR: no RNA size: 1569
ORF size: 963CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 2026.00frame shift in genome: no % Coverage: 100.00
has start codon: yes stop codon in genome: no # of Alignments: 2
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.