Human Gene GRIP2 (uc021wtn.1)
  Description: Homo sapiens glutamate receptor interacting protein 2 (GRIP2), mRNA.
Transcript (Including UTRs)
   Position: hg19 chr3:14,530,619-14,583,588 Size: 52,970 Total Exon Count: 26 Strand: -
Coding Region
   Position: hg19 chr3:14,535,173-14,583,588 Size: 48,416 Coding Exon Count: 26 

Page IndexSequence and LinksUniProtKB CommentsPrimersGenetic AssociationsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
GO AnnotationsmRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated at UCSC: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr3:14,530,619-14,583,588)mRNA (may differ from genome)Protein (1140 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
GeneNetworkH-INVHGNCHPRDHuman Cortex Gene ExpressionLynx
MGIneXtProtPubMedReactomeTreefamUniProtKB
WikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: GRIP2_HUMAN
DESCRIPTION: RecName: Full=Glutamate receptor-interacting protein 2; Short=GRIP-2;
FUNCTION: May play a role as a localized scaffold for the assembly of a multiprotein signaling complex and as mediator of the trafficking of its binding partners at specific subcellular location in neurons (By similarity).
SUBUNIT: Interacts with EFNB1, EFNB3, GRIA2, GRIA3, CSPG4 and GRIPAP1. Can form homomultimers and heteromultimers with GRIP1 (By similarity). Interacts with the C-terminal tail of PRLHR.
SUBCELLULAR LOCATION: Cytoplasm (By similarity). Membrane; Peripheral membrane protein (By similarity).
DOMAIN: PDZ 5 mediates the C-terminal binding of GRIA2 and GRIA3. PDZ 6 mediates interaction with the PDZ recognition motif of EFNB1. PDZ 7 mediates interaction with CSPG4 (By similarity).
SIMILARITY: Belongs to the GRIP2 family.
SIMILARITY: Contains 7 PDZ (DHR) domains.
SEQUENCE CAUTION: Sequence=BAB21810.2; Type=Erroneous initiation;

-  Primer design for this transcript
 

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Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database (archive): GRIP2
CDC HuGE Published Literature: GRIP2
Positive Disease Associations: Cognitive performance , Psychomotor Performance
Related Studies:
  1. Cognitive performance
    Need ,et al. 2009, A Genome-wide Study of Common SNPs and CNVs in Cognitive Performance in the CANTAB battery, Human molecular genetics 2009 18- 23 : 4650-61. [PubMed 19734545]
  2. Psychomotor Performance
    Anna C Need et al. Human molecular genetics 2009, A genome-wide study of common SNPs and CNVs in cognitive performance in the CANTAB., Human molecular genetics. [PubMed 19734545]

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 4.65 RPKM in Heart - Left Ventricle
Total median expression: 55.40 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
3' UTR -1903.104554-0.418 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR001478 - PDZ

Pfam Domains:
PF00595 - PDZ domain (Also known as DHR or GLGF)

SCOP Domains:
50156 - PDZ domain-like

Protein Data Bank (PDB) 3-D Structure
MuPIT help
1V62 - NMR MuPIT 1X5R - NMR MuPIT


ModBase Predicted Comparative 3D Structure on Q9C0E4
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologGenome BrowserGenome BrowserNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGDEnsembl   
 Protein SequenceProtein Sequence   
 AlignmentAlignment   

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0030159 receptor signaling complex scaffold activity

Cellular Component:
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0016020 membrane


-  Descriptions from all associated GenBank mRNAs
  AB051506 - Homo sapiens KIAA1719 mRNA for KIAA1719 protein.
AK024507 - Homo sapiens mRNA for FLJ00117 protein, partial cds.
AB384271 - Synthetic construct DNA, clone: pF1KSDA1719, Homo sapiens GRIP2 gene for glutamate receptor interacting protein 2, complete cds, without stop codon, in Flexi system.
LF207296 - JP 2014500723-A/14799: Polycomb-Associated Non-Coding RNAs.
JD330165 - Sequence 311189 from Patent EP1572962.
JD067055 - Sequence 48079 from Patent EP1572962.
JD409832 - Sequence 390856 from Patent EP1572962.
JD069687 - Sequence 50711 from Patent EP1572962.
JD310901 - Sequence 291925 from Patent EP1572962.
JD239805 - Sequence 220829 from Patent EP1572962.
JD344608 - Sequence 325632 from Patent EP1572962.
JD423934 - Sequence 404958 from Patent EP1572962.
JD043646 - Sequence 24670 from Patent EP1572962.
JD374702 - Sequence 355726 from Patent EP1572962.
JD515608 - Sequence 496632 from Patent EP1572962.
JD508486 - Sequence 489510 from Patent EP1572962.
JD527816 - Sequence 508840 from Patent EP1572962.
JD179390 - Sequence 160414 from Patent EP1572962.
JD471871 - Sequence 452895 from Patent EP1572962.
JD064337 - Sequence 45361 from Patent EP1572962.
JD344784 - Sequence 325808 from Patent EP1572962.
JD186772 - Sequence 167796 from Patent EP1572962.
JD062674 - Sequence 43698 from Patent EP1572962.
JD440113 - Sequence 421137 from Patent EP1572962.
JD336823 - Sequence 317847 from Patent EP1572962.
JD450531 - Sequence 431555 from Patent EP1572962.
JD350336 - Sequence 331360 from Patent EP1572962.
JD090218 - Sequence 71242 from Patent EP1572962.
JD184306 - Sequence 165330 from Patent EP1572962.
JD565302 - Sequence 546326 from Patent EP1572962.
JD358928 - Sequence 339952 from Patent EP1572962.
JD160612 - Sequence 141636 from Patent EP1572962.
JD357388 - Sequence 338412 from Patent EP1572962.
AF052177 - Homo sapiens clone 24510 mRNA sequence.
JD219074 - Sequence 200098 from Patent EP1572962.
JD262995 - Sequence 244019 from Patent EP1572962.
JD494739 - Sequence 475763 from Patent EP1572962.
JD410832 - Sequence 391856 from Patent EP1572962.
JD258124 - Sequence 239148 from Patent EP1572962.
JD141060 - Sequence 122084 from Patent EP1572962.
JD491389 - Sequence 472413 from Patent EP1572962.
JD116318 - Sequence 97342 from Patent EP1572962.
JD547221 - Sequence 528245 from Patent EP1572962.
JD554731 - Sequence 535755 from Patent EP1572962.
JD276500 - Sequence 257524 from Patent EP1572962.
JD248894 - Sequence 229918 from Patent EP1572962.
JD188312 - Sequence 169336 from Patent EP1572962.
JD372785 - Sequence 353809 from Patent EP1572962.
JD201742 - Sequence 182766 from Patent EP1572962.
JD218370 - Sequence 199394 from Patent EP1572962.
JD110459 - Sequence 91483 from Patent EP1572962.
JD220120 - Sequence 201144 from Patent EP1572962.
JD300664 - Sequence 281688 from Patent EP1572962.
JD564703 - Sequence 545727 from Patent EP1572962.
JD280427 - Sequence 261451 from Patent EP1572962.
JD392544 - Sequence 373568 from Patent EP1572962.
JD192396 - Sequence 173420 from Patent EP1572962.
JD422630 - Sequence 403654 from Patent EP1572962.
JD399734 - Sequence 380758 from Patent EP1572962.
JD158152 - Sequence 139176 from Patent EP1572962.
JD483839 - Sequence 464863 from Patent EP1572962.
JD076683 - Sequence 57707 from Patent EP1572962.
JD375408 - Sequence 356432 from Patent EP1572962.
JD299788 - Sequence 280812 from Patent EP1572962.
JD096259 - Sequence 77283 from Patent EP1572962.
JD380265 - Sequence 361289 from Patent EP1572962.
JD527753 - Sequence 508777 from Patent EP1572962.
JD527752 - Sequence 508776 from Patent EP1572962.
JD301849 - Sequence 282873 from Patent EP1572962.
JD537196 - Sequence 518220 from Patent EP1572962.
JD427277 - Sequence 408301 from Patent EP1572962.
JD367353 - Sequence 348377 from Patent EP1572962.
JD328717 - Sequence 309741 from Patent EP1572962.
JD339446 - Sequence 320470 from Patent EP1572962.
JD073725 - Sequence 54749 from Patent EP1572962.
JD471158 - Sequence 452182 from Patent EP1572962.
JD346888 - Sequence 327912 from Patent EP1572962.
JD084825 - Sequence 65849 from Patent EP1572962.
JD382747 - Sequence 363771 from Patent EP1572962.
JD076607 - Sequence 57631 from Patent EP1572962.
JD439853 - Sequence 420877 from Patent EP1572962.
JD396933 - Sequence 377957 from Patent EP1572962.
JD287775 - Sequence 268799 from Patent EP1572962.
JD457897 - Sequence 438921 from Patent EP1572962.
JD201078 - Sequence 182102 from Patent EP1572962.
JD364842 - Sequence 345866 from Patent EP1572962.
JD507331 - Sequence 488355 from Patent EP1572962.
JD377682 - Sequence 358706 from Patent EP1572962.
JD465750 - Sequence 446774 from Patent EP1572962.
JD215786 - Sequence 196810 from Patent EP1572962.
JD522119 - Sequence 503143 from Patent EP1572962.
JD485194 - Sequence 466218 from Patent EP1572962.
JD072458 - Sequence 53482 from Patent EP1572962.
JD382175 - Sequence 363199 from Patent EP1572962.
JD388548 - Sequence 369572 from Patent EP1572962.
MA442873 - JP 2018138019-A/14799: Polycomb-Associated Non-Coding RNAs.
JD125292 - Sequence 106316 from Patent EP1572962.
JD210633 - Sequence 191657 from Patent EP1572962.
JD191074 - Sequence 172098 from Patent EP1572962.
JD382667 - Sequence 363691 from Patent EP1572962.
JD480049 - Sequence 461073 from Patent EP1572962.
JD248183 - Sequence 229207 from Patent EP1572962.
JD451895 - Sequence 432919 from Patent EP1572962.
JD443964 - Sequence 424988 from Patent EP1572962.
JD310008 - Sequence 291032 from Patent EP1572962.
JD426141 - Sequence 407165 from Patent EP1572962.
JD088796 - Sequence 69820 from Patent EP1572962.
AK074145 - Homo sapiens mRNA for FLJ00218 protein.
AK095762 - Homo sapiens cDNA FLJ38443 fis, clone FEBRA2018433, highly similar to Rattus norvegicus glutamate receptor interacting protein 2 (GRIP2) mRNA.
JD159115 - Sequence 140139 from Patent EP1572962.
JD377954 - Sequence 358978 from Patent EP1572962.
JD383359 - Sequence 364383 from Patent EP1572962.
JD209384 - Sequence 190408 from Patent EP1572962.
JD278233 - Sequence 259257 from Patent EP1572962.
JD510873 - Sequence 491897 from Patent EP1572962.
JD084966 - Sequence 65990 from Patent EP1572962.
JD544259 - Sequence 525283 from Patent EP1572962.
JD207250 - Sequence 188274 from Patent EP1572962.
JD138991 - Sequence 120015 from Patent EP1572962.
JD368764 - Sequence 349788 from Patent EP1572962.
JD519801 - Sequence 500825 from Patent EP1572962.
JD057047 - Sequence 38071 from Patent EP1572962.
JD139478 - Sequence 120502 from Patent EP1572962.
JD071534 - Sequence 52558 from Patent EP1572962.
JD206462 - Sequence 187486 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein Q9C0E4 (Reactome details) participates in the following event(s):

R-HSA-416985 Trafficking of GluR2-containing AMPA receptors to synapse
R-HSA-421007 Endocytosis of Ca impermeable AMPA receptors
R-HSA-416639 Trafficking of GluR2-containing AMPA receptors to extrasynaptic sites
R-HSA-416993 Trafficking of GluR2-containing AMPA receptors
R-HSA-399719 Trafficking of AMPA receptors
R-HSA-399721 Glutamate binding, activation of AMPA receptors and synaptic plasticity
R-HSA-112314 Neurotransmitter receptors and postsynaptic signal transmission
R-HSA-112315 Transmission across Chemical Synapses
R-HSA-112316 Neuronal System

-  Other Names for This Gene
  Alternate Gene Symbols: GRIP2_HUMAN, KIAA1719, NM_001080423, NP_001073892, Q8TEH9, Q9C0E4, Q9H7H3
UCSC ID: uc021wtn.1
RefSeq Accession: NM_001080423
Protein: Q9C0E4 (aka GRIP2_HUMAN or GRI2_HUMAN)

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: NM_001080423.2
exon count: 25CDS single in 3' UTR: no RNA size: 7977
ORF size: 3422CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 2975.00frame shift in genome: yes % Coverage: 99.96
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.