Description: Homo sapiens glutathione S-transferase theta 2 (GSTT2), mRNA. RefSeq Summary (NM_000854): The protein encoded by this gene, glutathione S-transferase (GST) theta 2 (GSTT2), is a member of a superfamily of proteins that catalyze the conjugation of reduced glutathione to a variety of electrophilic and hydrophobic compounds. Human GSTs can be divided into five main classes: alpha, mu, pi, theta, and zeta. The theta class includes GSTT1, GSTT2, and GSTT2B. GSTT2 and GSTT2B are nearly identical to each other, and share 55% amino acid identity with GSTT1. All three genes may play a role in human carcinogenesis. The GSTT2 gene is a pseudogene in some populations. [provided by RefSeq, Sep 2015]. Transcript (Including UTRs) Position: hg19 chr22:24,322,314-24,326,106 Size: 3,793 Total Exon Count: 5 Strand: + Coding Region Position: hg19 chr22:24,322,389-24,325,797 Size: 3,409 Coding Exon Count: 5
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Genetic Association Studies of Complex Diseases and Disorders
Genetic Association Database (archive): GSTT2 CDC HuGE Published Literature: GSTT2 Positive Disease Associations: colorectal cancer Related Studies:
colorectal cancer Jang, S. G. et al. 2007, GSTT2 promoter polymorphisms and colorectal cancer risk, BMC Cancer 2007 7(1) 16.
[PubMed 17250773]
Our results collectively suggest that SNPs and haplotypes of the GSTT2 promoter region are associated with colorectal cancer risk in the Korean population.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P0CG30
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
