Description: Homo sapiens protease, serine, 3 (PRSS3), transcript variant 1, mRNA. RefSeq Summary (NM_007343): This gene encodes a trypsinogen, which is a member of the trypsin family of serine proteases. This enzyme is expressed in the brain and pancreas and is resistant to common trypsin inhibitors. It is active on peptide linkages involving the carboxyl group of lysine or arginine. This gene is localized to the locus of T cell receptor beta variable orphans on chromosome 9. Four transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Oct 2010]. Transcript (Including UTRs) Position: hg19 chr9:33,750,464-33,799,229 Size: 48,766 Total Exon Count: 5 Strand: + Coding Region Position: hg19 chr9:33,750,515-33,799,178 Size: 48,664 Coding Exon Count: 5
ID:TRY3_HUMAN DESCRIPTION: RecName: Full=Trypsin-3; EC=3.4.21.4; AltName: Full=Brain trypsinogen; AltName: Full=Mesotrypsinogen; AltName: Full=Serine protease 3; AltName: Full=Serine protease 4; AltName: Full=Trypsin III; AltName: Full=Trypsin IV; Flags: Precursor; FUNCTION: Digestive protease specialized for the degradation of trypsin inhibitors. In the ileum, may be involved in defensin processing, including DEFA5. CATALYTIC ACTIVITY: Preferential cleavage: Arg-|-Xaa, Lys-|-Xaa. COFACTOR: Binds 1 calcium ion per subunit. SUBCELLULAR LOCATION: Secreted. TISSUE SPECIFICITY: Expressed in pancreas and brain. Also expressed in Paneth cells, at the base of small intestinal crypts. SIMILARITY: Belongs to the peptidase S1 family. SIMILARITY: Contains 1 peptidase S1 domain.
To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3
Genetic Association Studies of Complex Diseases and Disorders
Genetic Association Database (archive): PRSS3 CDC HuGE Published Literature: PRSS3 Positive Disease Associations: Bipolar Disorder Related Studies:
Bipolar Disorder Manuel A R Ferreira et al. Nature genetics 2008, Collaborative genome-wide association analysis supports a role for ANK3 and CACNA1C in bipolar disorder., Nature genetics.
[PubMed 18711365]
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P35030
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Mouse
Rat
Zebrafish
D. melanogaster
C. elegans
S. cerevisiae
No ortholog
No ortholog
No ortholog
No ortholog
No ortholog
No ortholog
Gene Ontology (GO) Annotations with Structured Vocabulary
US Server
