Human Gene NBR2 (uc002idf.3)
  Description: Homo sapiens neighbor of BRCA1 gene 2 (non-protein coding) (NBR2), non-coding RNA.
RefSeq Summary (NR_003108): This gene was identified by its close proximity on chromosome 17 to tumor suppressor gene BRCA1. Experimental evidence indicates that the two genes share a bi-directional promoter. Transcription for either gene is controlled individually by distinct transcriptional repressor factors. A short (112 amino acid) open reading frame is observed which includes a region derived from a LINE1 element. A strong Kozak signal is not observed for the putative ORF and the stop codon is more than 55 nucleotides upstream of the last splice site for the transcript, suggesting that the transcript is subject to nonsense-mediated decay. Therefore, this gene does not appear to encode a protein. Glucose starvation induces the expression of this gene and the long non-coding RNA transcribed by it functions with AMP-activated protein kinase in mediating the energy stress response. [provided by RefSeq, Aug 2016].
Transcript (Including UTRs)
   Position: hg19 chr17:41,277,600-41,292,342 Size: 14,743 Total Exon Count: 4 Strand: +


Page IndexSequence and LinksPrimersCTDRNA-Seq ExpressionMicroarray Expression
Other SpeciesmRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr17:41,277,600-41,292,342)mRNA (may differ from genome)No protein
Gene SorterGenome BrowserOther Species FASTATable SchemaBioGPSEnsembl
ExonPrimerGeneNetworkH-INVHGNCLynxPubMed
Treefam

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 5.03 RPKM in Thyroid
Total median expression: 130.46 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
      
      
      
      
      

-  Descriptions from all associated GenBank mRNAs
  CR936675 - Homo sapiens mRNA; cDNA DKFZp686F081 (from clone DKFZp686F081).
U88573 - Human NBR2 mRNA, complete cds.
BC107773 - Homo sapiens neighbor of BRCA1 gene 2, mRNA (cDNA clone IMAGE:6452095).
BC034248 - Homo sapiens neighbor of BRCA1 gene 2, mRNA (cDNA clone IMAGE:4339497), partial cds.
BC022065 - Homo sapiens neighbor of BRCA1 gene 2, mRNA (cDNA clone IMAGE:4826858), with apparent retained intron.
AK310868 - Homo sapiens cDNA, FLJ17910.
JD193890 - Sequence 174914 from Patent EP1572962.
JD399623 - Sequence 380647 from Patent EP1572962.
DQ600548 - Homo sapiens piRNA piR-38614, complete sequence.
JD292986 - Sequence 274010 from Patent EP1572962.
JD358948 - Sequence 339972 from Patent EP1572962.
KJ902079 - Synthetic construct Homo sapiens clone ccsbBroadEn_11473 NBR2 gene, encodes complete protein.
AY597810 - Homo sapiens chromosome 17 neighbor of BRCA1 gene 2 (NBR2) mRNA, complete cds, alternatively spliced.
JD273793 - Sequence 254817 from Patent EP1572962.
JD544619 - Sequence 525643 from Patent EP1572962.
JD176921 - Sequence 157945 from Patent EP1572962.
JD470624 - Sequence 451648 from Patent EP1572962.
JD246322 - Sequence 227346 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: BC034248
UCSC ID: uc002idf.3
RefSeq Accession: NR_003108

-  Gene Model Information
 
category: noncoding nonsense-mediated-decay: no RNA accession: BC034248.1
exon count: 4CDS single in 3' UTR: no RNA size: 2054
ORF size: 0CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 204.50frame shift in genome: no % Coverage: 99.37
has start codon: no stop codon in genome: no # of Alignments: 1
has end codon: no retained intron: yes # AT/AC introns 0
selenocysteine: no end bleed into intron: 1403# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.