Description: Homo sapiens zinc finger protein 644 (ZNF644), transcript variant 1, mRNA. RefSeq Summary (NM_201269): The protein encoded by this gene is a zinc finger transcription factor that may play a role in eye development. Defects in this gene have been associated with high myopia. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]. Transcript (Including UTRs) Position: hg19 chr1:91,380,857-91,487,812 Size: 106,956 Total Exon Count: 6 Strand: - Coding Region Position: hg19 chr1:91,382,355-91,447,910 Size: 65,556 Coding Exon Count: 5
ID:ZN644_HUMAN DESCRIPTION: RecName: Full=Zinc finger protein 644; AltName: Full=Zinc finger motif enhancer-binding protein 2; Short=Zep-2; FUNCTION: May be involved in transcriptional regulation. SUBCELLULAR LOCATION: Nucleus. TISSUE SPECIFICITY: Expressed in liver, placenta, retina and retinal pigment epithelium. DISEASE: Defects in ZNF644 are the cause of myopia type 21 (MYP21) [MIM:614167]. A refractive error of the eye, in which parallel rays from a distant object come to focus in front of the retina, vision being better for near objects than for far. SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein family. SIMILARITY: Contains 7 C2H2-type zinc fingers.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9H582
Front
Top
Side
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding GO:0003676 nucleic acid binding GO:0003677 DNA binding GO:0046872 metal ion binding
Biological Process: GO:0006351 transcription, DNA-templated GO:0006355 regulation of transcription, DNA-templated GO:0006357 regulation of transcription from RNA polymerase II promoter