Human Gene DNAJC16 (uc001aws.3)
  Description: Homo sapiens DnaJ (Hsp40) homolog, subfamily C, member 16 (DNAJC16), mRNA.
Transcript (Including UTRs)
   Position: hg19 chr1:15,853,352-15,898,228 Size: 44,877 Total Exon Count: 15 Strand: +
Coding Region
   Position: hg19 chr1:15,855,601-15,894,672 Size: 39,072 Coding Exon Count: 14 

Page IndexSequence and LinksUniProtKB CommentsPrimersGenetic AssociationsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
GO AnnotationsmRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr1:15,853,352-15,898,228)mRNA (may differ from genome)Protein (782 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
GeneNetworkH-INVHGNCHPRDLynxMGI
neXtProtPubMedTreefamUniProtKBBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: DJC16_HUMAN
DESCRIPTION: RecName: Full=DnaJ homolog subfamily C member 16; Flags: Precursor;
SUBCELLULAR LOCATION: Membrane; Single-pass type IV membrane protein (Potential).
SIMILARITY: Contains 1 J domain.
SIMILARITY: Contains 1 thioredoxin domain.
SEQUENCE CAUTION: Sequence=BAA76806.2; Type=Erroneous initiation;

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database (archive): DNAJC16
CDC HuGE Published Literature: DNAJC16

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 4.79 RPKM in Thyroid
Total median expression: 166.13 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -52.40120-0.437 Picture PostScript Text
3' UTR -1059.073556-0.298 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR001623 - DnaJ_N
IPR018253 - Heat_shock_DnaJ_CS
IPR003095 - Hsp_DnaJ
IPR012336 - Thioredoxin-like_fold
IPR013766 - Thioredoxin_domain

Pfam Domains:
PF00085 - Thioredoxin
PF00226 - DnaJ domain

SCOP Domains:
46565 - Chaperone J-domain
52833 - Thioredoxin-like

ModBase Predicted Comparative 3D Structure on Q9Y2G8
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologGenome BrowserGenome BrowserGenome BrowserGenome BrowserNo ortholog
Gene DetailsGene Details Gene DetailsGene Details 
Gene SorterGene Sorter Gene SorterGene Sorter 
 RGDEnsemblFlyBaseWormBase 
 Protein SequenceProtein SequenceProtein SequenceProtein Sequence 
 AlignmentAlignmentAlignmentAlignment 

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Biological Process:
GO:0045454 cell redox homeostasis

Cellular Component:
GO:0005829 cytosol
GO:0016020 membrane
GO:0016021 integral component of membrane


-  Descriptions from all associated GenBank mRNAs
  BC047363 - Homo sapiens DnaJ (Hsp40) homolog, subfamily C, member 16, mRNA (cDNA clone MGC:48460 IMAGE:5269539), complete cds.
AK091848 - Homo sapiens cDNA FLJ34529 fis, clone HLUNG2008139, highly similar to DnaJ homolog subfamily C member 16 precursor.
AX747219 - Sequence 744 from Patent EP1308459.
AB023179 - Homo sapiens KIAA0962 mRNA for KIAA0962 protein.
CR749567 - Homo sapiens mRNA; cDNA DKFZp686N0387 (from clone DKFZp686N0387).
CR749259 - Homo sapiens mRNA; cDNA DKFZp781I1547 (from clone DKFZp781I1547).
AL833299 - Homo sapiens mRNA; cDNA DKFZp451K019 (from clone DKFZp451K019).
AK292479 - Homo sapiens cDNA FLJ77609 complete cds, highly similar to Homo sapiens DnaJ (Hsp40) homolog, subfamily C, member 16 (DNAJC16), mRNA.
BX648982 - Homo sapiens mRNA; cDNA DKFZp686G1298 (from clone DKFZp686G1298).
CU690398 - Synthetic construct Homo sapiens gateway clone IMAGE:100020953 5' read DNAJC16 mRNA.
AB384062 - Synthetic construct DNA, clone: pF1KSDA0962, Homo sapiens DNAJC16 gene for DnaJ homolog, subfamily C, member 16, complete cds, without stop codon, in Flexi system.
JF432399 - Synthetic construct Homo sapiens clone IMAGE:100073601 DnaJ (Hsp40) homolog, subfamily C, member 16 (DNAJC16) gene, encodes complete protein.
KJ893360 - Synthetic construct Homo sapiens clone ccsbBroadEn_02754 DNAJC16 gene, encodes complete protein.
JD336663 - Sequence 317687 from Patent EP1572962.
JD129792 - Sequence 110816 from Patent EP1572962.
AK023805 - Homo sapiens cDNA FLJ13743 fis, clone PLACE3000226, highly similar to DnaJ homolog subfamily C member 16 precursor.
AL137715 - Homo sapiens mRNA; cDNA DKFZp434K0423 (from clone DKFZp434K0423).
DQ584767 - Homo sapiens piRNA piR-51879, complete sequence.
DQ582139 - Homo sapiens piRNA piR-32251, complete sequence.
BC031991 - Homo sapiens DnaJ (Hsp40) homolog, subfamily C, member 16, mRNA (cDNA clone IMAGE:4746620), partial cds.
AK022530 - Homo sapiens cDNA FLJ12468 fis, clone NT2RM1000857, highly similar to DnaJ homolog subfamily C member 16 precursor.
JD562742 - Sequence 543766 from Patent EP1572962.
JD359353 - Sequence 340377 from Patent EP1572962.
JD551759 - Sequence 532783 from Patent EP1572962.
JD062169 - Sequence 43193 from Patent EP1572962.
JD436047 - Sequence 417071 from Patent EP1572962.
DQ601048 - Homo sapiens piRNA piR-39114, complete sequence.
JD330245 - Sequence 311269 from Patent EP1572962.
JD249121 - Sequence 230145 from Patent EP1572962.
JD165935 - Sequence 146959 from Patent EP1572962.
JD413105 - Sequence 394129 from Patent EP1572962.
JD132021 - Sequence 113045 from Patent EP1572962.
JD195010 - Sequence 176034 from Patent EP1572962.
JD535778 - Sequence 516802 from Patent EP1572962.
JD554699 - Sequence 535723 from Patent EP1572962.
JD400231 - Sequence 381255 from Patent EP1572962.
JD308403 - Sequence 289427 from Patent EP1572962.
JD201052 - Sequence 182076 from Patent EP1572962.
JD210550 - Sequence 191574 from Patent EP1572962.
JD171197 - Sequence 152221 from Patent EP1572962.
JD496231 - Sequence 477255 from Patent EP1572962.
JD532037 - Sequence 513061 from Patent EP1572962.
JD106390 - Sequence 87414 from Patent EP1572962.
JD089963 - Sequence 70987 from Patent EP1572962.
JD090249 - Sequence 71273 from Patent EP1572962.
JD162897 - Sequence 143921 from Patent EP1572962.
JD369510 - Sequence 350534 from Patent EP1572962.
JD310886 - Sequence 291910 from Patent EP1572962.
JD302630 - Sequence 283654 from Patent EP1572962.
JD239840 - Sequence 220864 from Patent EP1572962.
JD304134 - Sequence 285158 from Patent EP1572962.
JD507223 - Sequence 488247 from Patent EP1572962.
JD286344 - Sequence 267368 from Patent EP1572962.
JD564806 - Sequence 545830 from Patent EP1572962.
JD486024 - Sequence 467048 from Patent EP1572962.
JD248537 - Sequence 229561 from Patent EP1572962.
JD346850 - Sequence 327874 from Patent EP1572962.
JD326178 - Sequence 307202 from Patent EP1572962.
JD154326 - Sequence 135350 from Patent EP1572962.
JD262515 - Sequence 243539 from Patent EP1572962.
JD562130 - Sequence 543154 from Patent EP1572962.
JD293294 - Sequence 274318 from Patent EP1572962.
JD258929 - Sequence 239953 from Patent EP1572962.
JD257354 - Sequence 238378 from Patent EP1572962.
JD142671 - Sequence 123695 from Patent EP1572962.
JD321699 - Sequence 302723 from Patent EP1572962.
JD505505 - Sequence 486529 from Patent EP1572962.
JD359687 - Sequence 340711 from Patent EP1572962.
JD242706 - Sequence 223730 from Patent EP1572962.
JD330996 - Sequence 312020 from Patent EP1572962.
JD482512 - Sequence 463536 from Patent EP1572962.
JD184398 - Sequence 165422 from Patent EP1572962.
JD342077 - Sequence 323101 from Patent EP1572962.
JD513915 - Sequence 494939 from Patent EP1572962.
JD460121 - Sequence 441145 from Patent EP1572962.
JD414794 - Sequence 395818 from Patent EP1572962.
JD120551 - Sequence 101575 from Patent EP1572962.
JD379647 - Sequence 360671 from Patent EP1572962.
JD356302 - Sequence 337326 from Patent EP1572962.
JD505734 - Sequence 486758 from Patent EP1572962.
JD107502 - Sequence 88526 from Patent EP1572962.
JD036702 - Sequence 17726 from Patent EP1572962.
JD304322 - Sequence 285346 from Patent EP1572962.
JD059985 - Sequence 41009 from Patent EP1572962.
JD305548 - Sequence 286572 from Patent EP1572962.
JD543512 - Sequence 524536 from Patent EP1572962.
JD504142 - Sequence 485166 from Patent EP1572962.
JD263264 - Sequence 244288 from Patent EP1572962.
JD330948 - Sequence 311972 from Patent EP1572962.
JD538805 - Sequence 519829 from Patent EP1572962.
JD342081 - Sequence 323105 from Patent EP1572962.
JD346741 - Sequence 327765 from Patent EP1572962.
JD183398 - Sequence 164422 from Patent EP1572962.
JD186626 - Sequence 167650 from Patent EP1572962.
JD299715 - Sequence 280739 from Patent EP1572962.
JD534014 - Sequence 515038 from Patent EP1572962.
JD044819 - Sequence 25843 from Patent EP1572962.
JD335069 - Sequence 316093 from Patent EP1572962.
JD492999 - Sequence 474023 from Patent EP1572962.
JD463441 - Sequence 444465 from Patent EP1572962.
JD299485 - Sequence 280509 from Patent EP1572962.
JD024728 - Sequence 5752 from Patent EP1572962.
JD067580 - Sequence 48604 from Patent EP1572962.
JD338635 - Sequence 319659 from Patent EP1572962.
JD034815 - Sequence 15839 from Patent EP1572962.
JD187661 - Sequence 168685 from Patent EP1572962.
JD423847 - Sequence 404871 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: DJC16_HUMAN, KIAA0962, NM_015291, NP_056106, Q68D57, Q86X32, Q8N5P4, Q9Y2G8
UCSC ID: uc001aws.3
RefSeq Accession: NM_015291
Protein: Q9Y2G8 (aka DJC16_HUMAN)
CCDS: CCDS30606.1

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: NM_015291.2
exon count: 15CDS single in 3' UTR: no RNA size: 6035
ORF size: 2349CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 4821.00frame shift in genome: no % Coverage: 99.83
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: yes # AT/AC introns 0
selenocysteine: no end bleed into intron: 3498# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.