Human Gene TMEM198 (uc002vmf.3)
  Description: Homo sapiens transmembrane protein 198 (TMEM198), mRNA.
Transcript (Including UTRs)
   Position: hg19 chr2:220,408,745-220,415,317 Size: 6,573 Total Exon Count: 5 Strand: +
Coding Region
   Position: hg19 chr2:220,409,450-220,414,576 Size: 5,127 Coding Exon Count: 4 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr2:220,408,745-220,415,317)mRNA (may differ from genome)Protein (360 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
GeneNetworkH-INVHGNCHPRDLynxMGI
neXtProtPubMedTreefamUniProtKBBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: TM198_HUMAN
DESCRIPTION: RecName: Full=Transmembrane protein 198;
SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein (Potential).
SIMILARITY: Belongs to the TMEM198 family.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 18.02 RPKM in Pituitary
Total median expression: 225.90 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -191.60394-0.486 Picture PostScript Text
3' UTR -335.30741-0.452 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR025256 - DUF4203

Pfam Domains:
PF13886 - Domain of unknown function (DUF4203)

ModBase Predicted Comparative 3D Structure on Q66K66
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologGenome BrowserGenome BrowserNo orthologNo ortholog
Gene Details  Gene Details  
Gene Sorter  Gene Sorter  
  EnsemblFlyBase  
  Protein SequenceProtein Sequence  
  AlignmentAlignment  

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Biological Process:
GO:0007275 multicellular organism development
GO:0016055 Wnt signaling pathway
GO:0090263 positive regulation of canonical Wnt signaling pathway

Cellular Component:
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0031410 cytoplasmic vesicle


-  Descriptions from all associated GenBank mRNAs
  LF205258 - JP 2014500723-A/12761: Polycomb-Associated Non-Coding RNAs.
BC068567 - Homo sapiens similar to RIKEN cDNA A230078I05 gene, mRNA (cDNA clone IMAGE:5275321).
BC080573 - Homo sapiens transmembrane protein 198, mRNA (cDNA clone MGC:99813 IMAGE:6569597), complete cds.
JD514838 - Sequence 495862 from Patent EP1572962.
JD075895 - Sequence 56919 from Patent EP1572962.
JD550485 - Sequence 531509 from Patent EP1572962.
JD125333 - Sequence 106357 from Patent EP1572962.
JD210467 - Sequence 191491 from Patent EP1572962.
JD260624 - Sequence 241648 from Patent EP1572962.
JD451053 - Sequence 432077 from Patent EP1572962.
JD193508 - Sequence 174532 from Patent EP1572962.
JD296972 - Sequence 277996 from Patent EP1572962.
JD104315 - Sequence 85339 from Patent EP1572962.
CU687342 - Synthetic construct Homo sapiens gateway clone IMAGE:100023127 5' read MGC99813 mRNA.
HQ447518 - Synthetic construct Homo sapiens clone IMAGE:100070857; CCSB015008_01 similar to RIKEN cDNA A230078I05 gene (TMEM198) gene, encodes complete protein.
LF318663 - JP 2014500723-A/126166: Polycomb-Associated Non-Coding RNAs.
AK302369 - Homo sapiens cDNA FLJ55861 complete cds.
AK123175 - Homo sapiens cDNA FLJ41180 fis, clone BRACE2043142.
LF318664 - JP 2014500723-A/126167: Polycomb-Associated Non-Coding RNAs.
JD086673 - Sequence 67697 from Patent EP1572962.
JD398953 - Sequence 379977 from Patent EP1572962.
JD167558 - Sequence 148582 from Patent EP1572962.
JD383914 - Sequence 364938 from Patent EP1572962.
JD101255 - Sequence 82279 from Patent EP1572962.
JD120880 - Sequence 101904 from Patent EP1572962.
JD528035 - Sequence 509059 from Patent EP1572962.
JD485869 - Sequence 466893 from Patent EP1572962.
JD472937 - Sequence 453961 from Patent EP1572962.
JD066895 - Sequence 47919 from Patent EP1572962.
JD190604 - Sequence 171628 from Patent EP1572962.
JD487532 - Sequence 468556 from Patent EP1572962.
JD240239 - Sequence 221263 from Patent EP1572962.
JD164239 - Sequence 145263 from Patent EP1572962.
JD148112 - Sequence 129136 from Patent EP1572962.
JD477208 - Sequence 458232 from Patent EP1572962.
JD112749 - Sequence 93773 from Patent EP1572962.
JD492983 - Sequence 474007 from Patent EP1572962.
JD273574 - Sequence 254598 from Patent EP1572962.
MA440835 - JP 2018138019-A/12761: Polycomb-Associated Non-Coding RNAs.
MA554240 - JP 2018138019-A/126166: Polycomb-Associated Non-Coding RNAs.
MA554241 - JP 2018138019-A/126167: Polycomb-Associated Non-Coding RNAs.

-  Other Names for This Gene
  Alternate Gene Symbols: NM_001005209, NP_001005209, Q66K66, TM198_HUMAN
UCSC ID: uc002vmf.3
RefSeq Accession: NM_001005209
Protein: Q66K66 (aka TM198_HUMAN)
CCDS: CCDS33385.1

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: NM_001005209.1
exon count: 5CDS single in 3' UTR: no RNA size: 2239
ORF size: 1083CDS single in intron: no Alignment % ID: 99.91
txCdsPredict score: 2057.00frame shift in genome: no % Coverage: 99.06
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 123# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.