Description: Homo sapiens interleukin 18 receptor accessory protein (IL18RAP), mRNA. RefSeq Summary (NM_003853): The protein encoded by this gene is an accessory subunit of the heterodimeric receptor for interleukin 18 (IL18), a proinflammatory cytokine involved in inducing cell-mediated immunity. This protein enhances the IL18-binding activity of the IL18 receptor and plays a role in signaling by IL18. Mutations in this gene are associated with Crohn's disease and inflammatory bowel disease, and susceptibility to celiac disease and leprosy. Alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Feb 2014]. Transcript (Including UTRs) Position: hg19 chr2:103,035,254-103,069,024 Size: 33,771 Total Exon Count: 12 Strand: + Coding Region Position: hg19 chr2:103,039,738-103,068,641 Size: 28,904 Coding Exon Count: 10
ID:I18RA_HUMAN DESCRIPTION: RecName: Full=Interleukin-18 receptor accessory protein; Short=IL-18 receptor accessory protein; Short=IL-18RAcP; AltName: Full=Accessory protein-like; Short=AcPL; AltName: Full=CD218 antigen-like family member B; AltName: Full=CDw218b; AltName: Full=IL-1R accessory protein-like; Short=IL-1RAcPL; AltName: Full=Interleukin-1 receptor 7; Short=IL-1R-7; Short=IL-1R7; AltName: Full=Interleukin-18 receptor accessory protein-like; AltName: Full=Interleukin-18 receptor beta; Short=IL-18R-beta; Short=IL-18Rbeta; AltName: CD_antigen=CD218b; Flags: Precursor; FUNCTION: Required for the high affinity binding of interleukin 18 (IL-18) to its receptor complex (By similarity). Together with IL18R1 mediates IL-18-dependent activation of NF-kappa-B and JNK. SUBUNIT: Together with IL18R1, probably belongs to the IL-18 receptor complex. Seems not to interact directly with IL-18. SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein (Potential). TISSUE SPECIFICITY: Strongly expressed in peripheral blood leukocytes, spleen, lung, and, to a lesser extent, in colon, but not in any other tissue tested. Strongly expressed in T-cells polarized with IL-12. Specifically coexpressed with IL18R1 in Th1 cells. INDUCTION: Induced by IFN-alpha and IL12/interleukin-12 in natural killer (NK) cells and T-cells. SIMILARITY: Belongs to the interleukin-1 receptor family. SIMILARITY: Contains 2 Ig-like C2-type (immunoglobulin-like) domains. SIMILARITY: Contains 1 TIR domain.
Celiac Disease Patrick C A Dubois et al. Nature genetics 2010, Multiple common variants for celiac disease influencing immune gene expression., Nature genetics.
[PubMed 20190752]
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on O95256
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Mouse
Rat
Zebrafish
D. melanogaster
C. elegans
S. cerevisiae
No ortholog
No ortholog
No ortholog
No ortholog
No ortholog
No ortholog
Gene Ontology (GO) Annotations with Structured Vocabulary
US Server
