Description: Homo sapiens tumor necrosis factor (ligand) superfamily, member 14 (TNFSF14), transcript variant 1, mRNA. RefSeq Summary (NM_003807): The protein encoded by this gene is a member of the tumor necrosis factor (TNF) ligand family. This protein is a ligand for TNFRSF14, which is a member of the tumor necrosis factor receptor superfamily, and which is also known as a herpesvirus entry mediator (HVEM). This protein may function as a costimulatory factor for the activation of lymphoid cells and as a deterrent to infection by herpesvirus. This protein has been shown to stimulate the proliferation of T cells, and trigger apoptosis of various tumor cells. This protein is also reported to prevent tumor necrosis factor alpha mediated apoptosis in primary hepatocyte. Two alternatively spliced transcript variant encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]. Transcript (Including UTRs) Position: hg19 chr19:6,663,148-6,670,599 Size: 7,452 Total Exon Count: 5 Strand: - Coding Region Position: hg19 chr19:6,664,937-6,670,080 Size: 5,144 Coding Exon Count: 4
ID:TNF14_HUMAN DESCRIPTION: RecName: Full=Tumor necrosis factor ligand superfamily member 14; AltName: Full=Herpes virus entry mediator ligand; Short=HVEM-L; Short=Herpesvirus entry mediator ligand; AltName: CD_antigen=CD258; Contains: RecName: Full=Tumor necrosis factor ligand superfamily member 14, membrane form; Contains: RecName: Full=Tumor necrosis factor ligand superfamily member 14, soluble form; FUNCTION: Cytokine that binds to TNFRSF3/LTBR. Binding to the decoy receptor TNFRSF6B modulates its effects. Activates NFKB, stimulates the proliferation of T-cells, and inhibits growth of the adenocarcinoma HT-29. Acts as a receptor for Herpes simplex virus. SUBUNIT: Homotrimer. INTERACTION: Q92956:TNFRSF14; NbExp=2; IntAct=EBI-524131, EBI-1056653; O95407:TNFRSF6B; NbExp=2; IntAct=EBI-524131, EBI-524171; SUBCELLULAR LOCATION: Tumor necrosis factor ligand superfamily member 14, membrane form: Cell membrane; Single-pass type II membrane protein. SUBCELLULAR LOCATION: Tumor necrosis factor ligand superfamily member 14, soluble form: Secreted. SUBCELLULAR LOCATION: Isoform 2: Cytoplasm. TISSUE SPECIFICITY: Predominantly expressed in the spleen but also found in the brain. Weakly expressed in peripheral lymphoid tissues and in heart, placenta, liver, lung, appendix, and kidney, and no expression seen in fetal tissues, endocrine glands, or nonhematopoietic tumor lines. INDUCTION: Up-regulated after T-cell activation. PTM: N-glycosylated. PTM: The soluble form of isoform 1 derives from the membrane form by proteolytic processing. SIMILARITY: Belongs to the tumor necrosis factor family.
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Genetic Association Studies of Complex Diseases and Disorders
Genetic Association Database (archive): TNFSF14 CDC HuGE Published Literature: TNFSF14 Positive Disease Associations: Multiple Sclerosis Related Studies:
Multiple Sclerosis Stephen Sawcer et al. Nature 2011, Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis., Nature.
[PubMed 21833088]
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on O43557
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Mouse
Rat
Zebrafish
D. melanogaster
C. elegans
S. cerevisiae
No ortholog
No ortholog
No ortholog
No ortholog
No ortholog
No ortholog
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0005102 receptor binding GO:0005125 cytokine activity GO:0005164 tumor necrosis factor receptor binding GO:0005515 protein binding GO:0042802 identical protein binding GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process
Biological Process: GO:0006915 apoptotic process GO:0006955 immune response GO:0007165 signal transduction GO:0010469 regulation of receptor activity GO:0010820 positive regulation of T cell chemotaxis GO:0031295 T cell costimulation GO:0033209 tumor necrosis factor-mediated signaling pathway GO:0042098 T cell proliferation GO:0042110 T cell activation GO:0043029 T cell homeostasis GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process GO:0045663 positive regulation of myoblast differentiation GO:0071260 cellular response to mechanical stimulus GO:1901224 positive regulation of NIK/NF-kappaB signaling GO:1901741 positive regulation of myoblast fusion
US Server
