Human Gene HIST2H4A (uc001ess.3) Description and Page Index
  Description: Homo sapiens histone cluster 2, H4a (HIST2H4A), mRNA.
RefSeq Summary (NM_003548): Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. This structure consists of approximately 146 bp of DNA wrapped around a nucleosome, an octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H4 family. Transcripts from this gene lack polyA tails; instead, they contain a palindromic termination element. This gene is found in a histone cluster on chromosome 1. This gene is one of four histone genes in the cluster that are duplicated; this record represents the centromeric copy. [provided by RefSeq, Aug 2015]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: HY098221.1 [ECO:0000345] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript replication-dependent histone :: PMID: 12408966 ##RefSeq-Attributes-END##
Transcript (Including UTRs)
   Position: hg19 chr1:149,804,221-149,804,616 Size: 396 Total Exon Count: 1 Strand: +
Coding Region
   Position: hg19 chr1:149,804,249-149,804,560 Size: 312 Coding Exon Count: 1 

Page IndexSequence and LinksUniProtKB CommentsCTDGene AllelesMicroarray Expression
RNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA DescriptionsPathways
Other NamesModel InformationMethods
Data last updated: 2013-06-14

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr1:149,804,221-149,804,616)mRNA (may differ from genome)Protein (103 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaBioGPS
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PubMedReactomeStanford SOURCEUniProtKBWikipedia

-  Comments and Description Text from UniProtKB
DESCRIPTION: RecName: Full=Histone H4;
FUNCTION: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
SUBUNIT: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
INTERACTION: Q12830:BPTF; NbExp=3; IntAct=EBI-302023, EBI-1560273; Q12830-4:BPTF; NbExp=16; IntAct=EBI-302023, EBI-4288838; P49450:CENPA; NbExp=4; IntAct=EBI-302023, EBI-1751979; O14929:HAT1; NbExp=4; IntAct=EBI-302023, EBI-2339359; Q9Y468:L3MBTL1; NbExp=3; IntAct=EBI-302023, EBI-1265089; P49736:MCM2; NbExp=3; IntAct=EBI-302023, EBI-374819; P25205:MCM3; NbExp=2; IntAct=EBI-302023, EBI-355153; P33992:MCM5; NbExp=2; IntAct=EBI-302023, EBI-359410; O14744:PRMT5; NbExp=3; IntAct=EBI-302023, EBI-351098; Q16576:RBBP7; NbExp=4; IntAct=EBI-302023, EBI-352227; Q9NQR1:SETD8; NbExp=4; IntAct=EBI-302023, EBI-1268946;
SUBCELLULAR LOCATION: Nucleus. Chromosome.
PTM: Acetylation at Lys-6 (H4K5ac), Lys-9 (H4K8ac), Lys-13 (H4K12ac) and Lys-17 (H4K16ac) occurs in coding regions of the genome but not in heterochromatin.
PTM: Citrullination at Arg-4 (H4R3ci) by PADI4 impairs methylation.
PTM: Monomethylation and asymmetric dimethylation at Arg-4 (H4R3me1 and H4R3me2a, respectively) by PRMT1 favors acetylation at Lys-9 (H4K8ac) and Lys-13 (H4K12ac). Demethylation is performed by JMJD6. Symmetric dimethylation on Arg-4 (H4R3me2s) by the PRDM1/PRMT5 complex may play a crucial role in the germ-cell lineage.
PTM: Monomethylated, dimethylated or trimethylated at Lys-21 (H4K20me1, H4K20me2, H4K20me3). Monomethylation is performed by SET8. Trimethylation is performed by SUV420H1 and SUV420H2 and induces gene silencing.
PTM: Phosphorylated by PAK2 at Ser-48 (H4S47ph). This phosphorylation increases the association of H3.3-H4 with the histone chaperone HIRA, thus promoting nucleosome assembly of H3.3-H4 and inhibiting nucleosome assembly of H3.1-H4.
PTM: Ubiquitinated by the CUL4-DDB-RBX1 complex in response to ultraviolet irradiation. This may weaken the interaction between histones and DNA and facilitate DNA accessibility to repair proteins. Monoubiquitinated at Lys-92 of histone H4 (H4K91ub1) in response to DNA damage. The exact role of H4K91ub1 in DNA damage response is still unclear but it may function as a licensing signal for additional histone H4 post-translational modifications such as H4 Lys-21 methylation (H4K20me).
PTM: Sumoylated, which is associated with transcriptional repression.
PTM: Crotonylation (Kcr) is specifically present in male germ cells and marks testis-specific genes in post-meiotic cells, including X-linked genes that escape sex chromosome inactivation in haploid cells. Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors. It is also associated with post-meiotically activated genes on autosomes.
SIMILARITY: Belongs to the histone H4 family.
SEQUENCE CAUTION: Sequence=AAI28106.1; Type=Frameshift; Positions=3;

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -3.9028-0.139 Picture PostScript Text
3' UTR -14.7056-0.262 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR009072 - Histone-fold
IPR007125 - Histone_core_D
IPR001951 - Histone_H4
IPR019809 - Histone_H4_CS

Pfam Domains:
PF02969 - TATA box binding protein associated factor (TAF)
PF15511 - Centromere kinetochore component CENP-T histone fold

SCOP Domains:
47113 - Histone-fold

Protein Data Bank (PDB) 3-D Structure
MuPIT help

- X-ray MuPIT

- X-ray MuPIT

To conserve bandwidth, only the images from the first 3 structures are shown.
3A6N - X-ray MuPIT 3AFA - X-ray MuPIT 3AN2 - X-ray MuPIT
3AV1 - X-ray MuPIT 3AV2 - X-ray MuPIT 3AYW - X-ray MuPIT
3AZE - X-ray MuPIT 3AZF - X-ray MuPIT 3AZG - X-ray MuPIT
3AZH - X-ray MuPIT 3AZI - X-ray MuPIT 3AZJ - X-ray MuPIT
3AZK - X-ray MuPIT 3AZL - X-ray MuPIT 3AZM - X-ray MuPIT
3AZN - X-ray MuPIT 3CFS - X-ray MuPIT 3CFV - X-ray MuPIT
3F9W - X-ray MuPIT 3F9X - X-ray MuPIT 3F9Y - X-ray MuPIT
3F9Z - X-ray MuPIT 3NQJ - X-ray MuPIT 3NQU - X-ray MuPIT
3O36 - X-ray MuPIT 3QZS - X-ray MuPIT 3QZT - X-ray MuPIT
3QZV - X-ray MuPIT 3R45 - X-ray MuPIT 3UVW - X-ray MuPIT
3UVX - X-ray MuPIT 3UVY - X-ray MuPIT 3UW9 - X-ray MuPIT
4H9N - X-ray 4H9O - X-ray

ModBase Predicted Comparative 3D Structure on P62805
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0003677 DNA binding
GO:0003723 RNA binding
GO:0005515 protein binding
GO:0019904 protein domain specific binding
GO:0042393 histone binding
GO:0046982 protein heterodimerization activity

Biological Process:
GO:0000183 chromatin silencing at rDNA
GO:0006303 double-strand break repair via nonhomologous end joining
GO:0006334 nucleosome assembly
GO:0006335 DNA replication-dependent nucleosome assembly
GO:0006336 DNA replication-independent nucleosome assembly
GO:0006352 DNA-templated transcription, initiation
GO:0016233 telomere capping
GO:0032200 telomere organization
GO:0034080 CENP-A containing nucleosome assembly
GO:0044267 cellular protein metabolic process
GO:0045652 regulation of megakaryocyte differentiation
GO:0045653 negative regulation of megakaryocyte differentiation
GO:0045814 negative regulation of gene expression, epigenetic
GO:0051290 protein heterotetramerization
GO:0060964 regulation of gene silencing by miRNA

Cellular Component:
GO:0000228 nuclear chromosome
GO:0000784 nuclear chromosome, telomeric region
GO:0000786 nucleosome
GO:0000788 nuclear nucleosome
GO:0005576 extracellular region
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005694 chromosome
GO:0016020 membrane
GO:0032991 macromolecular complex
GO:0070062 extracellular exosome

-  Descriptions from all associated GenBank mRNAs
  LP895153 - Sequence 17 from Patent EP3253886.
LP895175 - Sequence 39 from Patent EP3253886.
AK316561 - Homo sapiens cDNA, FLJ92294, Homo sapiens H4 histone family, member N (H4FN), mRNA.
BC093969 - Homo sapiens histone cluster 2, H4b, mRNA (cDNA clone MGC:121004 IMAGE:7939814), complete cds.
BC112193 - Homo sapiens histone cluster 2, H4b, mRNA (cDNA clone MGC:138398 IMAGE:8327661), complete cds.
BC108260 - Homo sapiens histone cluster 2, H4b, mRNA (cDNA clone IMAGE:6011519).
JD149522 - Sequence 130546 from Patent EP1572962.
BC019846 - Homo sapiens histone cluster 2, H4b, mRNA (cDNA clone IMAGE:5113140).
AB590914 - Synthetic construct DNA, clone: pFN21AE1601, Homo sapiens HIST2H4A gene for histone cluster 2, H4a, without stop codon, in Flexi system.
KJ896309 - Synthetic construct Homo sapiens clone ccsbBroadEn_05703 HIST2H4B gene, encodes complete protein.
BC146448 - Synthetic construct Homo sapiens clone IMAGE:100015142, MGC:180220 histone cluster 2, H4a (HIST2H4A) mRNA, encodes complete protein.
BC153063 - Synthetic construct Homo sapiens clone IMAGE:100016351, MGC:184285 histone cluster 2, H4a (HIST2H4A) mRNA, encodes complete protein.
CR542172 - Homo sapiens full open reading frame cDNA clone RZPDo834C0824D for gene HIST2H4, histone 2, H4; complete cds, incl. stopcodon.

-  Biochemical and Signaling Pathways
  KEGG - Kyoto Encyclopedia of Genes and Genomes
hsa05322 - Systemic lupus erythematosus

Reactome (by CSHL, EBI, and GO)

Protein P62805 (Reactome details) participates in the following event(s):

R-HSA-3321805 NSL acetylates histone H4
R-HSA-3321883 MSL acetylates histone H4
R-HSA-3662318 Type B histone acetlytransferase complex acetylates histone H4
R-HSA-4570485 SUMOylation of Histone H4 with SUMO3
R-HSA-4570496 SUMOylation of Histone H4 with SUMO1
R-HSA-5205798 PRMT1,PRMT6 methylate arginine-4 of histone H4
R-HSA-5423038 SETD8 (KMT5A) methylates lysine-21 of histone H4 (H4K20)
R-HSA-5423117 PHF8 demethylates MeK21-histone H4
R-HSA-5661124 JMJD6 demethylates MeR4-HIST1H4
R-HSA-5661126 PRMT1,PRMT6 methylate methyl-lysine-4 of histone H4
R-HSA-5661125 JMJD6 demethylates Me2sR4-HIST1H4
R-HSA-5212679 DNMT3A binds Me2sR4-HIST1H4
R-HSA-5651654 SUV420H1 (KMT5B), SUV420H2 (KMT5C), (possibly SMYD3 (KMT3E)) methylate methyl-lysine-21 of histone H4 (H4K20)
R-HSA-5651657 SUV420H1, SUV420H2, (possibly SMYD3 (KMT3E)) methylate dimethyl-lysine-21 of histone H4 (H4K20)
R-HSA-176700 Incorporation Of Extended And Processed Telomere End Into Higher Order T-Loop And Associated Protein Structure
R-HSA-181450 Incorporation Of Extended And Processed Telomere End Into Associated Protein Structure
R-HSA-5250938 B-WICH:histone acetyltransferase acetylates histone H3 at lysine-9
R-HSA-5683930 WICH phosphorylates H2AFX on Y142
R-HSA-1214188 PRDM9 trimethylates histone H3
R-HSA-8935730 RUNX1:CBFB, SIN3A(SIN3B), PRMT6 and HDAC1 bind the ITGA2B promoter
R-HSA-8935740 RUNX1 and GATA1 bind the promoter of the ITGA2B gene
R-HSA-8936599 RUNX1:CBFB, SIN3A(SIN3B), PRMT6 and HDAC1 bind the GP1BA promoter
R-HSA-8936616 RUNX1 and GATA1 bind the promoter of the GP1BA gene
R-HSA-8936979 RUNX1 and GATA1 bind the promoter of the THBS1 gene
R-HSA-8936989 RUNX1:CBFB, SIN3A(SIN3B), PRMT6 and HDAC1 bind the THBS1 gene promoter
R-HSA-8937037 RUNX1 and GATA1 bind the promoter of the MIR27A gene
R-HSA-8937118 RUNX1:CBFB, SIN3A(SIN3B), PRMT6 and HDAC1 bind the MIR27A gene promoter
R-HSA-5693602 ATM recognizes H2AFX-Nucleosomes
R-HSA-3318415 ATF2 acetylates histone H2B, H4
R-HSA-3301345 Elongator complex acetylates replicative histone H3, H4
R-HSA-3697920 CLOCK acetylates lysine-10 of histone H3, H4
R-NUL-4549261 Elongator complex acetylates H3, H4
R-NUL-4568946 Clock acetylates histones H3, H4
R-HSA-5144542 CLOCK acetylates lysine-15 of histone H3, H4
R-HSA-3321975 NuA4 complex acetylates histone H2A, HIST1H4
R-HSA-3697008 CREBBP acetylates histone H2B, H3, H4
R-HSA-3662335 EP300 acetylates histone H2A, H2B, H3, H4
R-HSA-5205861 COPRS:CCND1:CDK4:PRMT5:pT5-WDR77 methylates arginine-4 of histone H4 (H4R3)
R-HSA-2288097 Condensin II complex binds H4K20me1-containing nucleosomes
R-HSA-2245218 CDK1 phosphorylates PHF8
R-HSA-5684071 RNF4 ubiquitinates MDC1
R-HSA-5693599 Association of Ku heterodimer with ends of DNA double-strand break
R-HSA-3451147 KAT5 HAT complex acetylates TCF4 gene at histone H4
R-HSA-427383 CBX3 (HP1gamma) binds histone H3 dimethylated at lysine-9
R-HSA-427528 Formation of energy-dependent Nucleolar Silencing Complex (eNoSC)
R-HSA-5227490 NoRC:HDAC:DNMT methylates cytosine of the rRNA genes
R-HSA-427336 TTF1:rRNA promoter:ERCC6:EHMT2 complex dimethylates histone H3 at lysine-9.
R-HSA-427527 eNoSC dimethylates histone H3 at lysine-9
R-HSA-3788748 EHMT1:EHMT2 methylates IL6 promoter
R-HSA-3788745 EHMT1:EHMT2 methylates IL8 promoter
R-HSA-427337 MBD2 binds methylcytosine in chromatin
R-HSA-9011983 Overexpressed HIST1H2AC and ESR1:ESTG bind MYC and BCL2 genes
R-HSA-5334164 DNMT3B:DNMT3L binds chromatin
R-HSA-5334179 DNMT3A:DNMT3L binds chromatin
R-HSA-5578742 AGO1,2:small RNA complexes interact with chromatin
R-HSA-427514 eNoSC deacetylates histone H3
R-HSA-3240295 PRC2-EZH2 trimethylates nucleosomes associated with CDKN2A promoter
R-HSA-3222593 KDM6B demethylates H3K27me3 on p16-INK4A promoter
R-HSA-5334151 DNMT1 methylates cytosine in hemimethylated DNA
R-HSA-5334160 UHRF1:Chromatin binds DNMT1
R-HSA-5334099 UHRF1 binds chromatin with hemimethylated cytosine
R-HSA-8865491 RUNX1:CBFB:KMT2A binds SPI1 (PU.1) gene
R-HSA-9011949 KDM4B demethylates H3K9me3 on estrogen-responsive target enhancers
R-HSA-3229089 PRC1.4 complex binds H3K27Me3 nucleosomes on CDKN2A promoter
R-HSA-3229102 p-MAPKAPK3 phosphorylates BMI1
R-HSA-606326 HJURP:CENPA complex localizes to the centromere
R-HSA-912467 BRCA1 is recruited to unsynapsed regions
R-HSA-912470 ATR phosphorylates Histone H2A.X at unsynapsed regions
R-HSA-5693583 MDC1 associates with gamma-H2AFX at nuclear foci
R-HSA-5683967 EYA1-4 dephosphorylates tyrosine Y142 of H2AFX
R-HSA-8936481 Core MLL complex methylates H3K4Me2-Nucleosome at the ITGA2B gene promoter
R-HSA-8936621 Core MLL complex methylates H3K4Me2-Nucleosome at the GP1BA gene promoter
R-HSA-8937016 Core MLL complex methylates H3K4Me2-Nucleosome at the THBS1 gene promoter
R-HSA-8937050 Core MLL complex methylates H3K4Me2-Nucleosome at the MIR27A gene promoter
R-HSA-8936584 PRMT6 arginine methylates H3K4me2-Nucleosome at the ITGA2B gene promoter
R-HSA-8936608 PRMT6 arginine methylates H3K4me2-Nucleosome at the GP1BA gene promoter
R-HSA-8937022 PRMT6 arginine methylates H3K4me2-Nucleosome at the THBS1 gene promoter
R-HSA-8937113 PRMT6 arginine methylates H3K4me2-Nucleosome at the MIR27A gene promoter
R-HSA-9009371 Binding of AP1 transcriptional activator complexes to CCND1 promoter
R-HSA-9009065 FOXA1 and GATA3 bind to CCND1 promoter
R-HSA-2301205 SETD8 monomethylates histone H4
R-HSA-2172678 PHF8 demethylates histone H4K20me1
R-HSA-3364026 SET1 complex trimethylates H3K4 at the MYC gene
R-HSA-3769447 HDAC1/2 containing-complexes deacetylate histones
R-HSA-3777129 HDAC3 containing complexes deacetylate histone
R-HSA-3782637 HDAC8 deacetylates histones
R-HSA-3782655 HDAC10 deacetylates histone
R-HSA-5625774 PKN1:AR complex binds promoters of KLK2 and KLK3 genes
R-HSA-9011952 ESR1:ESTG and KDM4B bind H3K9me3 target gene enhancers
R-HSA-5625849 Demethylase KDM1A binds KLK2 and KLK3 promoters
R-HSA-5625797 KDM4C demethylates Me3K-10-H3 associated with KLK2 and KLK3 promoters
R-HSA-5625870 KDM1A demethylates monomethylated H3K9 (MeK-10-H3) at KLK2 and KLK3 promoters
R-HSA-5693549 ATM phosphorylates histone H2AFX on S139 at DNA DSBs
R-HSA-5683986 APBB1 and MAPK8 bind diphosphorylated H2AFX
R-HSA-9011984 KDM1A is recruited to MYC and BCL2 genes
R-HSA-9011981 EP300 is recruited to MYC and BCL2 genes
R-HSA-9011985 KDM1A demethylates H3 on MYC and BCL genes in response to estrogen
R-HSA-2294600 CDK1 phosphorylates condensin II subunit NCAPD3
R-HSA-2294580 PLK1 hyperphosphorylates Condensin II complex
R-HSA-2294590 PLK1 binds phosphorylated condensin II complex
R-HSA-212263 PRC2 trimethylates histone H3 at lysine-27
R-HSA-212222 PRC2 recruits DNA methyltransferases
R-HSA-5334097 DNMT3B:DNMT3L methylates cytosine in DNA
R-HSA-5334152 DNMT3A:DNMT3L methylates cytosine in DNA
R-HSA-8865498 KMT2A trimethylates nucleosomes at the SPI1 gene locus producing H3K4Me3 mark
R-HSA-912450 ATR Kinase is recruited to unsynapsed regions
R-HSA-5682967 WHSC1 binds DNA DSBs
R-HSA-5693536 ATM phosphorylates MDC1
R-HSA-5625784 PKN1 phosphorylates histone 3 of nucleosomes associate with KLK2 and KLK3 promoters
R-HSA-5625796 Demethylase KDM4C binds KLK2 and KLK3 promoters
R-HSA-5625848 KDM1A demethylates dimethylated H3K9 (Me2K-10-H3) at KLK2 and KLK3 promoters
R-HSA-5683964 ATM phosphorylates EYA1-4
R-HSA-977224 Serum amyloid P binds DNA and chromatin
R-HSA-5682983 ATM phosphorylates WHSC1
R-HSA-5682965 WHSC1 dimethylates histone H4 on lysine K21 at DSBs
R-HSA-5682992 KDM4A,B bind H4K20Me2
R-HSA-5682588 RNF8 binds phosphorylated MDC1 at DNA DSBs
R-HSA-5693566 TP53BP1 associates with H4K20Me2 at DNA DSBs
R-HSA-5683077 RNF8 and RNF168 ubiquitinate KDM4A,B
R-HSA-5682586 HERC2 and PIAS4 are recruited to DNA DSBs
R-HSA-5682629 HERC2 facilitates UBE2N:UBE2V2 binding to RNF8
R-HSA-5682607 PIAS4 SUMOylates HERC2 with SUMO1 at DNA DSBs
R-HSA-5682863 RNF168 binds DNA DSBs
R-HSA-5682858 RNF8 and RNF168 ubiquitinate H2AFX
R-HSA-5683384 UIMC1 and FAM175A bind DNA DSBs
R-HSA-5683405 PPP5C dephosphorylates TP53BP1
R-HSA-5683425 ATM phosphorylates TP53BP1 at DNA DSBs
R-HSA-5682598 ATM phosphorylates HERC2
R-HSA-5693551 Phosphorylation of BRCA1-A complex at multiple sites by ATM
R-HSA-5683385 Formation of BRCA1-A complex at DNA DSBs
R-HSA-5683735 CHEK2 is recruited to DNA DSBs
R-HSA-5683801 CHEK2 phosphorylates BRCA1
R-HSA-69891 Phosphorylation and activation of CHEK2 by ATM
R-HSA-5684052 PIAS4 SUMOylates MDC1
R-HSA-5686685 RIF1 and PAX1IP bind TP53BP1 at DNA DSBs
R-HSA-5686900 TP53BP1 recruits DCLRE1C to ATM
R-HSA-5686704 Activated ATM phosphorylates DCLRE1C
R-HSA-3214847 HATs acetylate histones
R-HSA-4551638 SUMOylation of chromatin organization proteins
R-HSA-3214858 RMTs methylate histone arginines
R-HSA-3214841 PKMTs methylate histone lysines
R-HSA-3214842 HDMs demethylate histones
R-HSA-171306 Packaging Of Telomere Ends
R-HSA-5250924 B-WICH complex positively regulates rRNA expression
R-HSA-912446 Meiotic recombination
R-HSA-5693565 Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
R-HSA-8936459 RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
R-HSA-3247509 Chromatin modifying enzymes
R-HSA-3108232 SUMO E3 ligases SUMOylate target proteins
R-HSA-2299718 Condensation of Prophase Chromosomes
R-HSA-5693607 Processing of DNA double-strand break ends
R-HSA-5693571 Nonhomologous End-Joining (NHEJ)
R-HSA-1221632 Meiotic synapsis
R-HSA-2559586 DNA Damage/Telomere Stress Induced Senescence
R-HSA-201722 Formation of the beta-catenin:TCF transactivating complex
R-HSA-157579 Telomere Maintenance
R-HSA-427389 ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression
R-HSA-427359 SIRT1 negatively regulates rRNA expression
R-HSA-427413 NoRC negatively regulates rRNA expression
R-HSA-2559582 Senescence-Associated Secretory Phenotype (SASP)
R-HSA-9018519 Estrogen-dependent gene expression
R-HSA-212300 PRC2 methylates histones and DNA
R-HSA-5334118 DNA methylation
R-HSA-5578749 Transcriptional regulation by small RNAs
R-HSA-2559580 Oxidative Stress Induced Senescence
R-HSA-8939236 RUNX1 regulates transcription of genes involved in differentiation of HSCs
R-HSA-5250913 Positive epigenetic regulation of rRNA expression
R-HSA-606279 Deposition of new CENPA-containing nucleosomes at the centromere
R-HSA-1500620 Meiosis
R-HSA-5693606 DNA Double Strand Break Response
R-HSA-5617472 Activation of anterior HOX genes in hindbrain development during early embryogenesis
R-HSA-8878171 Transcriptional regulation by RUNX1
R-HSA-3214815 HDACs deacetylate histones
R-HSA-5625886 Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
R-HSA-4839726 Chromatin organization
R-HSA-2990846 SUMOylation
R-HSA-68875 Mitotic Prophase
R-HSA-5693567 HDR through Homologous Recombination (HR) or Single Strand Annealing (SSA)
R-HSA-5693532 DNA Double-Strand Break Repair
R-HSA-2559583 Cellular Senescence
R-HSA-201681 TCF dependent signaling in response to WNT
R-HSA-73886 Chromosome Maintenance
R-HSA-5250941 Negative epigenetic regulation of rRNA expression
R-HSA-8939211 ESR-mediated signaling
R-HSA-212165 Epigenetic regulation of gene expression
R-HSA-211000 Gene Silencing by RNA
R-HSA-774815 Nucleosome assembly
R-HSA-1474165 Reproduction
R-HSA-1640170 Cell Cycle
R-HSA-5619507 Activation of HOX genes during differentiation
R-HSA-212436 Generic Transcription Pathway
R-HSA-5625740 RHO GTPases activate PKNs
R-HSA-597592 Post-translational protein modification
R-HSA-977225 Amyloid fiber formation
R-HSA-68886 M Phase
R-HSA-5693538 Homology Directed Repair
R-HSA-73894 DNA Repair
R-HSA-2262752 Cellular responses to stress
R-HSA-195721 Signaling by WNT
R-HSA-9006931 Signaling by Nuclear Receptors
R-HSA-74160 Gene expression (Transcription)
R-HSA-1266738 Developmental Biology
R-HSA-73857 RNA Polymerase II Transcription
R-HSA-195258 RHO GTPase Effectors
R-HSA-392499 Metabolism of proteins
R-HSA-69278 Cell Cycle (Mitotic)
R-HSA-8953897 Cellular responses to external stimuli
R-HSA-162582 Signal Transduction
R-HSA-194315 Signaling by Rho GTPases
R-HSA-69473 G2/M DNA damage checkpoint
R-HSA-69481 G2/M Checkpoints
R-HSA-69620 Cell Cycle Checkpoints

-  Other Names for This Gene
  Alternate Gene Symbols: A2VCL0, H4/A, H4/B, H4/C, H4/D, H4/E, H4/G, H4/H, H4/I, H4/J, H4/K, H4/M, H4/N, H4/O, H4F2, H4FA, H4FB, H4FC, H4FD, H4FE, H4FG, H4FH, H4FI, H4FJ, H4FK, H4FM, H4FN, H4FO, H4_HUMAN, HIST1H4A, HIST1H4B, HIST1H4C, HIST1H4D, HIST1H4E, HIST1H4F, HIST1H4H, HIST1H4I, HIST1H4J, HIST1H4K, HIST1H4L, HIST2H4, HIST2H4B, HIST4H4, NM_003548, NP_778224, P02304, P02305, P62805, Q6DRA9, Q6FGB8, Q6NWP7
UCSC ID: uc001ess.3
RefSeq Accession: NM_003548
Protein: P62805 (aka H4_HUMAN)
CCDS: CCDS30847.1

-  Gene Model Information
category: coding nonsense-mediated-decay: no RNA accession: NM_003548.2
exon count: 1CDS single in 3' UTR: no RNA size: 396
ORF size: 312CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 512.00frame shift in genome: no % Coverage: 100.00
has start codon: yes stop codon in genome: no # of Alignments: 2
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.