Human Gene PPIAL4B (uc001esj.3) Description and Page Index
  Description: Homo sapiens peptidylprolyl isomerase A (cyclophilin A)-like 4B (PPIAL4B), mRNA.
Transcript (Including UTRs)
   Position: hg19 chr1:149,553,003-149,553,787 Size: 785 Total Exon Count: 1 Strand: +
Coding Region
   Position: hg19 chr1:149,553,078-149,553,572 Size: 495 Coding Exon Count: 1 

Page IndexSequence and LinksUniProtKB CommentsCTDGene AllelesRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
Other NamesModel InformationMethods
Data last updated: 2013-06-14

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr1:149,553,003-149,553,787)mRNA (may differ from genome)Protein (164 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaBioGPS
CGAPEnsemblEntrez GeneExonPrimerGeneCardsHGNC
HPRDLynxMGIneXtProtPubMedStanford SOURCE

-  Comments and Description Text from UniProtKB
DESCRIPTION: RecName: Full=Peptidyl-prolyl cis-trans isomerase A-like 4A/B/C; Short=PPIase A-like 4A; EC=; AltName: Full=Chromosome 1-amplified sequence 2; Short=COAS-2; AltName: Full=Cyclophilin homolog overexpressed in liver cancer;
FUNCTION: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity).
CATALYTIC ACTIVITY: Peptidylproline (omega=180) = peptidylproline (omega=0).
SUBCELLULAR LOCATION: Cytoplasm (By similarity).
TISSUE SPECIFICITY: Highly expressed in brain, ovary and mammary gland. Moderately expressed in lung, salivary gland, kidney, skin, adipose tissue, intestine and spleen. Weakly expressed in skeletal muscle, liver and stomach. Expressed in pleiomorphic and undifferentiated liposarcomas, osteosarcomas and breast carcinomas.
MISCELLANEOUS: It is one of seven related genes or pseudogenes found in a cluster, thought to result from gene duplication, on chromosome 1.
SIMILARITY: Belongs to the cyclophilin-type PPIase family. PPIase A subfamily.
SIMILARITY: Contains 1 PPIase cyclophilin-type domain.

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
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-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 0.00 RPKM in Adipose - Subcutaneous
Total median expression: 0.00 RPKM

View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -11.3075-0.151 Picture PostScript Text
3' UTR -50.19215-0.233 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR002130 - Cyclophilin-like_PPIase_dom
IPR024936 - Cyclophilin-type_PPIase
IPR020892 - Cyclophilin-type_PPIase_CS

Pfam Domains:
PF00160 - Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD

SCOP Domains:
50891 - Cyclophilin-like

ModBase Predicted Comparative 3D Structure on Q9Y536
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0003755 peptidyl-prolyl cis-trans isomerase activity
GO:0016853 isomerase activity

Biological Process:
GO:0000413 protein peptidyl-prolyl isomerization
GO:0006457 protein folding

Cellular Component:
GO:0005737 cytoplasm
GO:0070062 extracellular exosome

-  Descriptions from all associated GenBank mRNAs
  AB084917 - Homo sapiens mRNA for Cyclophilin-LC, complete cds.
BC130376 - Homo sapiens peptidylprolyl isomerase A (cyclophilin A)-like 4A, mRNA (cDNA clone MGC:163248 IMAGE:40146407), complete cds.
BC130378 - Homo sapiens peptidylprolyl isomerase A (cyclophilin A)-like 4A, mRNA (cDNA clone MGC:163250 IMAGE:40146409), complete cds.
BC172332 - Synthetic construct Homo sapiens clone IMAGE:100069026, MGC:199037 peptidylprolyl isomerase A (cyclophilin A)-like 4A (PPIAL4A) mRNA, encodes complete protein.
JD280425 - Sequence 261449 from Patent EP1572962.
JD146806 - Sequence 127830 from Patent EP1572962.
JD273789 - Sequence 254813 from Patent EP1572962.
JD451832 - Sequence 432856 from Patent EP1572962.
JD500334 - Sequence 481358 from Patent EP1572962.
JD297753 - Sequence 278777 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: COAS2, NM_001143883, NP_839944, PAL4A_HUMAN, PPIAL4A, PPIAL4C, Q9Y536
UCSC ID: uc001esj.3
RefSeq Accession: NM_001143883
Protein: Q9Y536 (aka PAL4A_HUMAN)

-  Gene Model Information
category: coding nonsense-mediated-decay: no RNA accession: NM_001143883.2
exon count: 1CDS single in 3' UTR: no RNA size: 785
ORF size: 495CDS single in intron: no Alignment % ID: 99.87
txCdsPredict score: 1091.00frame shift in genome: no % Coverage: 100.00
has start codon: yes stop codon in genome: no # of Alignments: 3
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
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-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.