Human Gene PRAMEF9 (uc001ava.1) Description and Page Index
  Description: Homo sapiens PRAME family member 9 (PRAMEF9), mRNA.
Transcript (Including UTRs)
   Position: hg19 chr1:13,641,973-13,648,988 Size: 7,016 Total Exon Count: 4 Strand: +
Coding Region
   Position: hg19 chr1:13,644,800-13,648,656 Size: 3,857 Coding Exon Count: 3 

Page IndexSequence and LinksUniProtKB CommentsGene AllelesRNA-Seq ExpressionMicroarray Expression
RNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA DescriptionsOther Names
Model InformationMethods
Data last updated: 2013-06-14

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr1:13,641,973-13,648,988)mRNA (may differ from genome)Protein (478 aa)
Gene SorterGenome BrowserOther Species FASTATable SchemaBioGPSCGAP
EnsemblEntrez GeneExonPrimerGeneCardsH-INVHGNC
HPRDLynxMGIneXtProtPubMedStanford SOURCE

-  Comments and Description Text from UniProtKB
DESCRIPTION: RecName: Full=PRAME family member 9/15;
SIMILARITY: Belongs to the PRAME family.
SIMILARITY: Contains 6 LRR (leucine-rich) repeats.

+  Common Gene Haplotype Alleles
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-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 0.00 RPKM in Adipose - Subcutaneous
Total median expression: 0.00 RPKM

View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -22.7094-0.241 Picture PostScript Text
3' UTR -94.90332-0.286 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR026292 - PRAME/Leu_rich_rep-con_p14
IPR026271 - PRAME_family

SCOP Domains:
52047 - RNI-like
52058 - L domain-like
52075 - Outer arm dynein light chain 1

ModBase Predicted Comparative 3D Structure on Q5VWM5
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Biological Process:
GO:0008284 positive regulation of cell proliferation
GO:0043066 negative regulation of apoptotic process
GO:0045596 negative regulation of cell differentiation
GO:0045892 negative regulation of transcription, DNA-templated

-  Descriptions from all associated GenBank mRNAs
  AK124292 - Homo sapiens cDNA FLJ42298 fis, clone TLIVE2009163, moderately similar to MELANOMA ANTIGEN PREFERENTIALLY EXPRESSED IN TUMORS.
BC137391 - Homo sapiens PRAME family member 9, mRNA (cDNA clone MGC:169012 IMAGE:9021389), complete cds.
BC171794 - Homo sapiens PRAME family member 9, mRNA (cDNA clone MGC:198509 IMAGE:9054448), complete cds.
BC101343 - Homo sapiens PRAME family member 9, mRNA (cDNA clone MGC:120474 IMAGE:40025151), complete cds.
JD519644 - Sequence 500668 from Patent EP1572962.
KJ896095 - Synthetic construct Homo sapiens clone ccsbBroadEn_05489 PRAMEF9 gene, encodes complete protein.
JD130563 - Sequence 111587 from Patent EP1572962.
JD507245 - Sequence 488269 from Patent EP1572962.
JD280995 - Sequence 262019 from Patent EP1572962.
JD226122 - Sequence 207146 from Patent EP1572962.
JD510285 - Sequence 491309 from Patent EP1572962.
JD274246 - Sequence 255270 from Patent EP1572962.
JD563781 - Sequence 544805 from Patent EP1572962.
JD326062 - Sequence 307086 from Patent EP1572962.
JD099835 - Sequence 80859 from Patent EP1572962.
JD045886 - Sequence 26910 from Patent EP1572962.
JD043213 - Sequence 24237 from Patent EP1572962.
JD455983 - Sequence 437007 from Patent EP1572962.
JD304218 - Sequence 285242 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: B2RPE1, NM_001010890, NP_001091846, PRAM9_HUMAN, PRAMEF15, Q08EQ1, Q5VWM5
UCSC ID: uc001ava.1
RefSeq Accession: NM_001010890
Protein: Q5VWM5 (aka PRAM9_HUMAN)
CCDS: CCDS44059.1

-  Gene Model Information
category: coding nonsense-mediated-decay: no RNA accession: NM_001010890.1
exon count: 4CDS single in 3' UTR: no RNA size: 1863
ORF size: 1437CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 3056.00frame shift in genome: no % Coverage: 100.00
has start codon: yes stop codon in genome: no # of Alignments: 2
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.