ID:TIKI2_HUMAN DESCRIPTION: RecName: Full=Metalloprotease TIKI2; EC=3.4.-.-; AltName: Full=TRAB domain-containing protein 2B; Flags: Precursor; FUNCTION: Metalloprotease that acts as a negative regulator of the Wnt signaling pathway by mediating the cleavage of the 8 N- terminal residues of a subset of Wnt proteins. Following cleavage, Wnt proteins become oxidized and form large disulfide-bond oligomers, leading to their inactivation. Able to cleave WNT3A, WNT5, but not WNT11. Required for head formation. COFACTOR: Divalent metal cations. Manganese or cobalt. ENZYME REGULATION: Inhibited by 1,10-phenanthroline, a metalloprotease inhibitor which is a divalent metal chelator. Also inhibited by EDTA. Not inhibited by Bestatin, an aminopeptidase inhibitor, nor to a mixture of inhibitors for serine, cysteine, and aspartic proteases and aminopeptidases. INTERACTION: P27467:Wnt3a (xeno); NbExp=2; IntAct=EBI-6257471, EBI-2899665; SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane protein. MISCELLANEOUS: Was named TIKI in reference to large-headed humanoid in Polynesian mythology (PubMed:22726442). SIMILARITY: Belongs to the TIKI family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on A6NFA1
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0006508 proteolysis GO:0016055 Wnt signaling pathway GO:0030178 negative regulation of Wnt signaling pathway GO:0032461 positive regulation of protein oligomerization GO:1904808 positive regulation of protein oxidation
Cellular Component: GO:0005886 plasma membrane GO:0005887 integral component of plasma membrane GO:0016020 membrane GO:0016021 integral component of membrane GO:0031301 integral component of organelle membrane
Descriptions from all associated GenBank mRNAs
JQ653416 - Homo sapiens TIKI2 (TIKI2) mRNA, complete cds. AK090467 - Homo sapiens mRNA for FLJ00388 protein. JD268784 - Sequence 249808 from Patent EP1572962. JD368230 - Sequence 349254 from Patent EP1572962. JD340259 - Sequence 321283 from Patent EP1572962. JD444470 - Sequence 425494 from Patent EP1572962. JD283057 - Sequence 264081 from Patent EP1572962. JD112844 - Sequence 93868 from Patent EP1572962. JD202161 - Sequence 183185 from Patent EP1572962. JD332733 - Sequence 313757 from Patent EP1572962. JD495354 - Sequence 476378 from Patent EP1572962. JD500655 - Sequence 481679 from Patent EP1572962. JD454265 - Sequence 435289 from Patent EP1572962. JD194424 - Sequence 175448 from Patent EP1572962. JD422908 - Sequence 403932 from Patent EP1572962. JD173228 - Sequence 154252 from Patent EP1572962. JD530129 - Sequence 511153 from Patent EP1572962. JD195281 - Sequence 176305 from Patent EP1572962. JD555936 - Sequence 536960 from Patent EP1572962. JD323611 - Sequence 304635 from Patent EP1572962. JD264361 - Sequence 245385 from Patent EP1572962. JD225518 - Sequence 206542 from Patent EP1572962. JD347261 - Sequence 328285 from Patent EP1572962. JD484273 - Sequence 465297 from Patent EP1572962. JD044712 - Sequence 25736 from Patent EP1572962. JD045604 - Sequence 26628 from Patent EP1572962. JD507340 - Sequence 488364 from Patent EP1572962. JD352285 - Sequence 333309 from Patent EP1572962. JD178619 - Sequence 159643 from Patent EP1572962. JD037347 - Sequence 18371 from Patent EP1572962. JD281853 - Sequence 262877 from Patent EP1572962. JD429201 - Sequence 410225 from Patent EP1572962. JD061773 - Sequence 42797 from Patent EP1572962. JD275399 - Sequence 256423 from Patent EP1572962. JD312673 - Sequence 293697 from Patent EP1572962. JD437329 - Sequence 418353 from Patent EP1572962. JD101589 - Sequence 82613 from Patent EP1572962. JD394324 - Sequence 375348 from Patent EP1572962. JD200161 - Sequence 181185 from Patent EP1572962. JD346897 - Sequence 327921 from Patent EP1572962. JD443335 - Sequence 424359 from Patent EP1572962. JD087650 - Sequence 68674 from Patent EP1572962. JD411649 - Sequence 392673 from Patent EP1572962. JD245018 - Sequence 226042 from Patent EP1572962. JD318814 - Sequence 299838 from Patent EP1572962. JD425641 - Sequence 406665 from Patent EP1572962. JD474207 - Sequence 455231 from Patent EP1572962. JD259472 - Sequence 240496 from Patent EP1572962. JD411260 - Sequence 392284 from Patent EP1572962. JD080618 - Sequence 61642 from Patent EP1572962. JD507464 - Sequence 488488 from Patent EP1572962. JD133883 - Sequence 114907 from Patent EP1572962. JD234504 - Sequence 215528 from Patent EP1572962. JD363126 - Sequence 344150 from Patent EP1572962. JD131364 - Sequence 112388 from Patent EP1572962. JD264537 - Sequence 245561 from Patent EP1572962. JD119521 - Sequence 100545 from Patent EP1572962. JD383643 - Sequence 364667 from Patent EP1572962. JD505023 - Sequence 486047 from Patent EP1572962. JD483265 - Sequence 464289 from Patent EP1572962. JD210224 - Sequence 191248 from Patent EP1572962. JD092690 - Sequence 73714 from Patent EP1572962. JD474852 - Sequence 455876 from Patent EP1572962. JD164439 - Sequence 145463 from Patent EP1572962. JD324916 - Sequence 305940 from Patent EP1572962. JD400353 - Sequence 381377 from Patent EP1572962. JD512012 - Sequence 493036 from Patent EP1572962. JD407748 - Sequence 388772 from Patent EP1572962. JD256876 - Sequence 237900 from Patent EP1572962. JD362760 - Sequence 343784 from Patent EP1572962. JD471638 - Sequence 452662 from Patent EP1572962. JD323136 - Sequence 304160 from Patent EP1572962. JD039054 - Sequence 20078 from Patent EP1572962. JD440549 - Sequence 421573 from Patent EP1572962. JD039493 - Sequence 20517 from Patent EP1572962. JD267865 - Sequence 248889 from Patent EP1572962. JD530197 - Sequence 511221 from Patent EP1572962. JD154938 - Sequence 135962 from Patent EP1572962. JD450162 - Sequence 431186 from Patent EP1572962. JD360934 - Sequence 341958 from Patent EP1572962. JD236083 - Sequence 217107 from Patent EP1572962. JD121526 - Sequence 102550 from Patent EP1572962. JD544933 - Sequence 525957 from Patent EP1572962. JD396683 - Sequence 377707 from Patent EP1572962.