Description: Homo sapiens squamous cell carcinoma antigen recognized by T cells 3 (SART3), mRNA. RefSeq Summary (NM_014706): The protein encoded by this gene is an RNA-binding nuclear protein that is a tumor-rejection antigen. This antigen possesses tumor epitopes capable of inducing HLA-A24-restricted and tumor-specific cytotoxic T lymphocytes in cancer patients and may be useful for specific immunotherapy. This gene product is found to be an important cellular factor for HIV-1 gene expression and viral replication. It also associates transiently with U6 and U4/U6 snRNPs during the recycling phase of the spliceosome cycle. This encoded protein is thought to be involved in the regulation of mRNA splicing. [provided by RefSeq, Jul 2008]. Transcript (Including UTRs) Position: hg19 chr12:108,915,991-108,955,165 Size: 39,175 Total Exon Count: 19 Strand: - Coding Region Position: hg19 chr12:108,917,234-108,954,930 Size: 37,697 Coding Exon Count: 19
ID:SART3_HUMAN DESCRIPTION: RecName: Full=Squamous cell carcinoma antigen recognized by T-cells 3; Short=SART-3; Short=hSART-3; AltName: Full=Tat-interacting protein of 110 kDa; Short=Tip110; FUNCTION: Regulates Tat transactivation activity through direct interaction. May be a cellular factor for HIV-1 gene expression and viral replication. SUBUNIT: Component of the 7SK snRNP complex at least composed of P-TEFb (composed of CDK9 and CCNT1/cyclin-T1), HEXIM1, HEXIM2, BCDIN3, SART3 proteins and 7SK and U6 snRNAs. Interacts with HIV-1 Tat. Interacts with EIF2C1 and EIF2C2. INTERACTION: Q15287:RNPS1; NbExp=5; IntAct=EBI-308619, EBI-395959; SUBCELLULAR LOCATION: Cytoplasm. Nucleus speckle. Note=Localized in speckles. Expressed in the nucleus of all of the malignant tumor cell lines tested and the majority of cancer tissues with various histologies, including squamous cell carcinomas (SCC), adenocarcinomas, melanomas and leukemias cells. However, this protein is undetectable in the nucleus of any cell lines of nonmalignant cells or normal tissues, except for the testis. Expressed in the cytoplasm of all the proliferating cells, including normal and malignant cells, but not in normal tissues, except for the testis and the fetal liver. TISSUE SPECIFICITY: Ubiquitously expressed. PTM: Phosphorylated upon DNA damage, probably by ATM or ATR. DISEASE: Defects in SART3 are the cause of disseminated superficial actinic porokeratosis type 1 (DSAP1) [MIM:175900]. DSAP1 is an autosomal dominant disorder, characterized by multiple superficial keratotic lesions surrounded by a slightly raised keratotic border, developing during the third or fourth decade of life on sun-exposed areas of skin. SIMILARITY: Contains 8 HAT repeats. SIMILARITY: Contains 2 RRM (RNA recognition motif) domains.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q15020
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
