Description: Homo sapiens protein kinase, cAMP-dependent, regulatory, type I, beta (PRKAR1B), transcript variant 3, mRNA. RefSeq Summary (NM_001164758): The protein encoded by this gene is a regulatory subunit of cyclic AMP-dependent protein kinase A (PKA), which is involved in the signaling pathway of the second messenger cAMP. Two regulatory and two catalytic subunits form the PKA holoenzyme, disbands after cAMP binding. The holoenzyme is involved in many cellular events, including ion transport, metabolism, and transcription. Several transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Aug 2015]. Transcript (Including UTRs) Position: hg19 chr7:588,834-767,313 Size: 178,480 Total Exon Count: 11 Strand: - Coding Region Position: hg19 chr7:590,067-751,142 Size: 161,076 Coding Exon Count: 10
ID:KAP1_HUMAN DESCRIPTION: RecName: Full=cAMP-dependent protein kinase type I-beta regulatory subunit; FUNCTION: Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells. SUBUNIT: The inactive holoenzyme is composed of two regulatory chains and two catalytic chains. Activation by cAMP releases the two active catalytic monomers and the regulatory dimer. Interacts with PRKX; regulates this cAMP-dependent protein kinase. TISSUE SPECIFICITY: Four types of regulatory chains are found: I- alpha, I-beta, II-alpha, and II-beta. Their expression varies among tissues and is in some cases constitutive and in others inducible. PTM: The pseudophosphorylation site binds to the substrate-binding region of the catalytic chain, resulting in the inhibition of its activity. SIMILARITY: Belongs to the cAMP-dependent kinase regulatory chain family. SIMILARITY: Contains 2 cyclic nucleotide-binding domains.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P31321
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0000166 nucleotide binding GO:0004862 cAMP-dependent protein kinase inhibitor activity GO:0005515 protein binding GO:0008603 cAMP-dependent protein kinase regulator activity GO:0030552 cAMP binding GO:0034236 protein kinase A catalytic subunit binding
Biological Process: GO:0001932 regulation of protein phosphorylation GO:0003091 renal water homeostasis GO:0006468 protein phosphorylation GO:0007596 blood coagulation GO:0007611 learning or memory GO:0034199 activation of protein kinase A activity GO:0071377 cellular response to glucagon stimulus GO:2000480 negative regulation of cAMP-dependent protein kinase activity
BC013368 - Homo sapiens cDNA clone IMAGE:3677877, containing frame-shift errors. AL833563 - Homo sapiens mRNA; cDNA DKFZp686J1344 (from clone DKFZp686J1344). M65066 - Human cAMP-dependent protein kinase regulatory subunit RI-beta mRNA, 3' end. BC026734 - Homo sapiens protein kinase, cAMP-dependent, regulatory, type I, beta, mRNA (cDNA clone MGC:34656 IMAGE:5141110), complete cds. BC036828 - Homo sapiens protein kinase, cAMP-dependent, regulatory, type I, beta, mRNA (cDNA clone MGC:46241 IMAGE:5247772), complete cds. AK289464 - Homo sapiens cDNA FLJ77959 complete cds, highly similar to Homo sapiens protein kinase, cAMP-dependent, regulatory, type I, beta (PRKAR1B), mRNA. AK297337 - Homo sapiens cDNA FLJ52674 complete cds, highly similar to cAMP-dependent protein kinase type I-beta regulatory subunit. AK098822 - Homo sapiens cDNA FLJ25956 fis, clone TST03939, highly similar to CAMP-DEPENDENT PROTEIN KINASE TYPE I-BETA REGULATORY CHAIN. AK315990 - Homo sapiens cDNA, FLJ78889 complete cds, highly similar to cAMP-dependent protein kinase type I-beta regulatory subunit. AK315951 - Homo sapiens cDNA, FLJ78850 complete cds, highly similar to cAMP-dependent protein kinase type I-beta regulatory subunit. EU832098 - Synthetic construct Homo sapiens clone HAIB:100067127; DKFZo008A1125 protein kinase, cAMP-dependent, regulatory, type I, beta protein (PRKAR1B) gene, encodes complete protein. EU832191 - Synthetic construct Homo sapiens clone HAIB:100067220; DKFZo004A1126 protein kinase, cAMP-dependent, regulatory, type I, beta protein (PRKAR1B) gene, encodes complete protein. AB385544 - Synthetic construct DNA, clone: pF1KB5260, Homo sapiens PRKAR1B gene for cAMP-dependent protein kinase type I-beta regulatory subunit, complete cds, without stop codon, in Flexi system. BC002470 - Homo sapiens mRNA similar to protein kinase, cAMP dependent regulatory, type I beta (cDNA clone IMAGE:3349336). JD030269 - Sequence 11293 from Patent EP1572962. JD021365 - Sequence 2389 from Patent EP1572962. BC070478 - Homo sapiens protein kinase, cAMP-dependent, regulatory, type I, beta, mRNA (cDNA clone IMAGE:6095844), complete cds. JD408790 - Sequence 389814 from Patent EP1572962.
Biochemical and Signaling Pathways
KEGG - Kyoto Encyclopedia of Genes and Genomes hsa04210 - Apoptosis hsa04910 - Insulin signaling pathway
BioCarta from NCI Cancer Genome Anatomy Project h_dreampathway - Repression of Pain Sensation by the Transcriptional Regulator DREAM h_chrebpPathway - ChREBP regulation by carbohydrates and cAMP h_GATA3pathway - GATA3 participate in activating the Th2 cytokine genes expression h_crebPathway - Transcription factor CREB and its extracellular signals h_gpcrPathway - Signaling Pathway from G-Protein Families h_igf1rPathway - Multiple antiapoptotic pathways from IGF-1R signaling lead to BAD phosphorylation h_mPRPathway - How Progesterone Initiates the Oocyte Maturation h_agpcrPathway - Attenuation of GPCR Signaling h_badPathway - Regulation of BAD phosphorylation h_carm1Pathway - Transcription Regulation by Methyltransferase of CARM1 h_no1Pathway - Actions of Nitric Oxide in the Heart h_stathminPathway - Stathmin and breast cancer resistance to antimicrotubule agents h_CSKPathway - Activation of Csk by cAMP-dependent Protein Kinase Inhibits Signaling through the T Cell Receptor h_ck1Pathway - Regulation of ck1/cdk5 by type 1 glutamate receptors h_pparaPathway - Mechanism of Gene Regulation by Peroxisome Proliferators via PPARa(alpha) h_shhPathway - Sonic Hedgehog (Shh) Pathway h_nos1Pathway - Nitric Oxide Signaling Pathway h_cftrPathway - Cystic fibrosis transmembrane conductance regulator (CFTR) and beta 2 adrenergic receptor (b2AR) pathway h_nfatPathway - NFAT and Hypertrophy of the heart (Transcription in the broken heart) h_plcePathway - Phospholipase C-epsilon pathway h_vipPathway - Neuropeptides VIP and PACAP inhibit the apoptosis of activated T cells h_mCalpainPathway - mCalpain and friends in Cell motility
Reactome (by CSHL, EBI, and GO)
Protein P31321 (Reactome details) participates in the following event(s):