Human Gene PI4KAP2 (uc011aie.1)
  Description: Homo sapiens phosphatidylinositol 4-kinase, catalytic, alpha pseudogene 2 (PI4KAP2), non-coding RNA.
Transcript (Including UTRs)
   Position: hg19 chr22:21,830,665-21,846,383 Size: 15,719 Total Exon Count: 13 Strand: -
Coding Region
   Position: hg19 chr22:21,830,874-21,842,641 Size: 11,768 Coding Exon Count: 12 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr22:21,830,665-21,846,383)mRNA (may differ from genome)Protein (460 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
BioGPSEnsemblExonPrimerGeneCardsH-INVHGNC
LynxMGIPubMedUniProtKBWikipedia

-  Comments and Description Text from UniProtKB
  ID: B4DSG9_HUMAN
DESCRIPTION: SubName: Full=cDNA FLJ60854, highly similar to Phosphatidylinositol 4-kinase alpha (EC 2.7.1.67);
SIMILARITY: Contains 1 PI3K/PI4K domain.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 6.54 RPKM in Pituitary
Total median expression: 142.05 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -50.00130-0.385 Picture PostScript Text
3' UTR -96.90209-0.464 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR011009 - Kinase-like_dom
IPR000403 - PI3/4_kinase_cat_dom
IPR018936 - PI3/4_kinase_CS
IPR015433 - PI_Kinase

Pfam Domains:
PF00454 - Phosphatidylinositol 3- and 4-kinase

SCOP Domains:
56112 - Protein kinase-like (PK-like)

ModBase Predicted Comparative 3D Structure on B4DSG9
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
      
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0016301 kinase activity
GO:0016740 transferase activity

Biological Process:
GO:0016310 phosphorylation
GO:0046854 phosphatidylinositol phosphorylation
GO:0048015 phosphatidylinositol-mediated signaling

Cellular Component:
GO:0005622 intracellular


-  Descriptions from all associated GenBank mRNAs
  BC020225 - Homo sapiens phosphatidylinositol 4-kinase, catalytic, alpha pseudogene 2, mRNA (cDNA clone IMAGE:4565073).
AK024034 - Homo sapiens cDNA FLJ13972 fis, clone Y79AA1001548, highly similar to PHOSPHATIDYLINOSITOL 4-KINASE ALPHA (EC 2.7.1.67).
AK298744 - Homo sapiens cDNA FLJ61336 complete cds, highly similar to Phosphatidylinositol 4-kinase alpha (EC 2.7.1.67).
CR456378 - Homo sapiens Em:AP000557.3 full length open reading frame (ORF) cDNA clone (cDNA clone C22ORF:pGEM.Em:AP000557.3.V6).
BC141652 - Synthetic construct Homo sapiens clone IMAGE:100000342, MGC:164686 phosphatidylinositol 4-kinase, catalytic, alpha pseudogene 2 (PI4KAP2) mRNA, encodes complete protein.
CU013083 - Homo sapiens Em:AP000557.C22.3, mRNA (cDNA clone IMAGE:100000342), complete cds, with stop codon, in Gateway system.
KJ904239 - Synthetic construct Homo sapiens clone ccsbBroadEn_13633 PI4KAP2 gene, encodes complete protein.
KJ905648 - Synthetic construct Homo sapiens clone ccsbBroadEn_15289 PI4KAP2 gene, encodes complete protein.
BC139841 - Homo sapiens similar to phosphatidylinositol 4-kinase alpha, mRNA (cDNA clone IMAGE:100000246), partial cds.
CU013371 - Homo sapiens Em:AP000557.C22.3, mRNA (cDNA clone IMAGE:100000246), complete cds, without stop codon, in Gateway system.
AK297163 - Homo sapiens cDNA FLJ59121 complete cds, highly similar to Phosphatidylinositol 4-kinase alpha (EC 2.7.1.67).
AK299734 - Homo sapiens cDNA FLJ60854 complete cds, highly similar to Phosphatidylinositol 4-kinase alpha (EC 2.7.1.67).
AK303215 - Homo sapiens cDNA FLJ57694 complete cds, highly similar to Phosphatidylinositol 4-kinase alpha (EC 2.7.1.67).
DI487283 - KR 1020100056450-A/379: DSRNA FOR TREATING VIRAL INFECTION.
AK126860 - Homo sapiens cDNA FLJ44912 fis, clone BRAMY3009491, highly similar to Phosphatidylinositol 4-kinase alpha (EC 2.7.1.67).
CU676516 - Synthetic construct Homo sapiens gateway clone IMAGE:100019903 5' read PI4KAP2 mRNA.
DI487263 - KR 1020100056450-A/359: DSRNA FOR TREATING VIRAL INFECTION.
DI487242 - KR 1020100056450-A/338: DSRNA FOR TREATING VIRAL INFECTION.
DI487301 - KR 1020100056450-A/397: DSRNA FOR TREATING VIRAL INFECTION.
DI487304 - KR 1020100056450-A/400: DSRNA FOR TREATING VIRAL INFECTION.
DI487307 - KR 1020100056450-A/403: DSRNA FOR TREATING VIRAL INFECTION.
HV593195 - JP 2010532163-A/316: dsRNA for treating viral infection.
HW663743 - JP 2013212113-A/212: dsRNA for treating viral infection.
JD275230 - Sequence 256254 from Patent EP1572962.
JD528084 - Sequence 509108 from Patent EP1572962.
JD225880 - Sequence 206904 from Patent EP1572962.
DI487258 - KR 1020100056450-A/354: DSRNA FOR TREATING VIRAL INFECTION.
JD406145 - Sequence 387169 from Patent EP1572962.
JD389964 - Sequence 370988 from Patent EP1572962.
JD091914 - Sequence 72938 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: AK299734, B4DSG9, B4DSG9_HUMAN
UCSC ID: uc011aie.1
RefSeq Accession: NR_003700
Protein: B4DSG9

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: AK299734.1
exon count: 13CDS single in 3' UTR: no RNA size: 1710
ORF size: 1383CDS single in intron: no Alignment % ID: 99.47
txCdsPredict score: 2731.50frame shift in genome: no % Coverage: 98.01
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.