Human Gene FERMT2 (uc001xac.3)
  Description: Homo sapiens fermitin family member 2 (FERMT2), transcript variant 2, mRNA.
Transcript (Including UTRs)
   Position: hg19 chr14:53,323,989-53,417,815 Size: 93,827 Total Exon Count: 16 Strand: -
Coding Region
   Position: hg19 chr14:53,325,095-53,417,286 Size: 92,192 Coding Exon Count: 15 

Page IndexSequence and LinksPrimersMalaCardsCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesmRNA Descriptions
PathwaysOther NamesModel InformationMethods
Data last updated at UCSC: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr14:53,323,989-53,417,815)mRNA (may differ from genome)Protein (687 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
GeneNetworkH-INVHGNCHPRDLynxMalacards
MGIOMIMPubMedReactomeTreefamUniProtKB
WikipediaBioGrid CRISPR DB

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: FERMT2
Diseases sorted by gene-association score: leukocyte adhesion deficiency, type iii (1)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 42.77 RPKM in Artery - Tibial
Total median expression: 754.71 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -96.35186-0.518 Picture PostScript Text
3' UTR -247.261106-0.224 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  Pfam Domains:
PF00169 - PH domain
PF00373 - FERM central domain

SCOP Domains:
47031 - Second domain of FERM
50729 - PH domain-like

ModBase Predicted Comparative 3D Structure on Q96AC1-3
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologGenome BrowserGenome BrowserNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGDEnsembl   
 Protein SequenceProtein Sequence   
 AlignmentAlignment   

-  Descriptions from all associated GenBank mRNAs
  AK091532 - Homo sapiens cDNA FLJ34213 fis, clone FCBBF3021524, highly similar to Mitogen inducible gene mig-2.
AX747041 - Sequence 566 from Patent EP1308459.
CU675940 - Synthetic construct Homo sapiens gateway clone IMAGE:100018414 5' read PLEKHC1 mRNA.
Z24725 - H.sapiens mitogen inducible gene mig-2, complete CDS.
AF443279 - Homo sapiens mitogen inducible 2 (MIG2) mRNA, complete cds.
AK291738 - Homo sapiens cDNA FLJ77570 complete cds, highly similar to Homo sapiens pleckstrin homology domain containing, family C (with FERM domain) member 1 (PLEKHC1), mRNA.
BC017327 - Homo sapiens fermitin family homolog 2 (Drosophila), mRNA (cDNA clone MGC:29726 IMAGE:4547604), complete cds.
EU831994 - Synthetic construct Homo sapiens clone HAIB:100067023; DKFZo008H1123 fermitin family homolog 2 (Drosophila) protein (FERMT2) gene, encodes complete protein.
EU979385 - Homo sapiens KINDLIN2 isoform 2 (FERMT2) mRNA, complete cds.
KJ898324 - Synthetic construct Homo sapiens clone ccsbBroadEn_07718 FERMT2 gene, encodes complete protein.
EU832087 - Synthetic construct Homo sapiens clone HAIB:100067116; DKFZo004H1124 fermitin family homolog 2 (Drosophila) protein (FERMT2) gene, encodes complete protein.
BX161467 - human full-length cDNA clone CS0DI065YG09 of Placenta of Homo sapiens (human).
BC011125 - Homo sapiens cDNA clone IMAGE:3445964, containing frame-shift errors.
AK126426 - Homo sapiens cDNA FLJ44462 fis, clone UTERU2024881, highly similar to Mitogen inducible gene mig-2.
CR749486 - Homo sapiens mRNA; cDNA DKFZp686G11125 (from clone DKFZp686G11125).
JD325517 - Sequence 306541 from Patent EP1572962.
JD345156 - Sequence 326180 from Patent EP1572962.
JD426890 - Sequence 407914 from Patent EP1572962.
JD228009 - Sequence 209033 from Patent EP1572962.
JD293699 - Sequence 274723 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein Q96AC1 (Reactome details) participates in the following event(s):

R-HSA-430341 Mig-2 recruits Migfilin to the cell-ECM adhesions
R-HSA-446353 Cell-extracellular matrix interactions
R-HSA-446728 Cell junction organization
R-HSA-1500931 Cell-Cell communication

-  Other Names for This Gene
  Alternate Gene Symbols: KIND2, MIG2, NM_001134999, NP_001128471, PLEKHC1, Q96AC1-3
UCSC ID: uc001xac.3
RefSeq Accession: NM_001134999
Protein: Q96AC1-3, splice isoform of Q96AC1 CCDS: CCDS9713.1, CCDS45107.1

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: NM_001134999.1
exon count: 16CDS single in 3' UTR: no RNA size: 3372
ORF size: 2064CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 4328.00frame shift in genome: no % Coverage: 99.53
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.