Description: Homo sapiens chromatin accessibility complex 1 (CHRAC1), transcript variant 1, mRNA. RefSeq Summary (NM_017444): CHRAC1 is a histone-fold protein that interacts with other histone-fold proteins to bind DNA in a sequence-independent manner. These histone-fold protein dimers combine within larger enzymatic complexes for DNA transcription, replication, and packaging.[supplied by OMIM, Apr 2004]. Transcript (Including UTRs) Position: hg19 chr8:141,521,397-141,527,252 Size: 5,856 Total Exon Count: 3 Strand: + Coding Region Position: hg19 chr8:141,521,599-141,525,346 Size: 3,748 Coding Exon Count: 3
ID:CHRC1_HUMAN DESCRIPTION: RecName: Full=Chromatin accessibility complex protein 1; Short=CHRAC-1; AltName: Full=Chromatin accessibility complex 15 kDa protein; Short=CHRAC-15; Short=HuCHRAC15; AltName: Full=DNA polymerase epsilon subunit p15; FUNCTION: Forms a complex with DNA polymerase epsilon subunit POLE3 and binds naked DNA, which is then incorporated into chromatin, aided by the nucleosome remodeling activity of ISWI/SNF2H and ACF1. SUBUNIT: Interacts with POLE3. Together with POLE3, ACF1 and ISWI/SNF2H proteins, it forms the ISWI chromatin-remodeling complex, CHRAC. SUBCELLULAR LOCATION: Nucleus (Potential). TISSUE SPECIFICITY: Expressed in all tissues tested, including, heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9NRG0
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.