Description: Homo sapiens matrilin 4 (MATN4), transcript variant 1, mRNA. RefSeq Summary (NM_003833): This gene encodes a member of von Willebrand factor A domain-containing protein family. The proteins of this family are thought to be involved in the formation of filamentous networks in the extracellular matrices of various tissues. This family member is thought to be play a role in reorganizing and regenerating the corneal matrix in granular and lattice type I dystrophies. It may also be involved in wound healing in the dentin-pulp complex. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2013]. Transcript (Including UTRs) Position: hg19 chr20:43,922,087-43,936,967 Size: 14,881 Total Exon Count: 10 Strand: - Coding Region Position: hg19 chr20:43,922,407-43,934,222 Size: 11,816 Coding Exon Count: 9
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Protein Domain and Structure Information
Pfam Domains: PF00092 - von Willebrand factor type A domain PF07645 - Calcium-binding EGF domain PF10393 - Trimeric coiled-coil oligomerisation domain of matrilin PF13519 - von Willebrand factor type A domain PF13768 - von Willebrand factor type A domain PF14670 - Coagulation Factor Xa inhibitory site
ModBase Predicted Comparative 3D Structure on O95460-2
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
