Description: Homo sapiens SEC16 homolog B (S. cerevisiae) (CRYZL2P-SEC16B), mRNA. RefSeq Summary (NM_033127): SEC16B is a mammalian homolog of S. cerevisiae Sec16 that is required for organization of transitional endoplasmic reticulum (ER) sites and protein export (Bhattacharyya and Glick, 2007 [PubMed 17192411]).[supplied by OMIM, Jun 2009]. Transcript (Including UTRs) Position: hg19 chr1:177,897,489-177,939,050 Size: 41,562 Total Exon Count: 26 Strand: - Coding Region Position: hg19 chr1:177,898,993-177,937,116 Size: 38,124 Coding Exon Count: 25
ID:SC16B_HUMAN DESCRIPTION: RecName: Full=Protein transport protein Sec16B; AltName: Full=Leucine zipper transcription regulator 2; AltName: Full=Regucalcin gene promoter region-related protein p117; Short=RGPR-p117; AltName: Full=SEC16 homolog B; FUNCTION: Required for secretory cargo traffic from the endoplasmic reticulum to the Golgi apparatus and for normal transitional endoplasmic reticulum (tER) organization. SUBUNIT: SEC16A and SEC16B are each present in multiple copies in a heteromeric complex. SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Peripheral membrane protein (By similarity). Golgi apparatus membrane; Peripheral membrane protein (By similarity). TISSUE SPECIFICITY: Ubiquitous. SIMILARITY: Belongs to the SEC16 family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF12931 - Sec23-binding domain of Sec16 PF12932 - Vesicle coat trafficking protein Sec16 mid-region
ModBase Predicted Comparative 3D Structure on Q96JE7
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0007029 endoplasmic reticulum organization GO:0007031 peroxisome organization GO:0010628 positive regulation of gene expression GO:0015031 protein transport GO:0016192 vesicle-mediated transport GO:0016559 peroxisome fission GO:0048208 COPII vesicle coating GO:0070863 positive regulation of protein exit from endoplasmic reticulum
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