Description: Homo sapiens lymphotoxin beta receptor (TNFR superfamily, member 3) (LTBR), transcript variant 1, mRNA. RefSeq Summary (NM_002342): This gene encodes a member of the tumor necrosis factor receptor superfamily. The major ligands of this receptor include lymphotoxin alpha/beta and tumor necrosis factor ligand superfamily member 14. The encoded protein plays a role in signalling during the development of lymphoid and other organs, lipid metabolism, immune response, and programmed cell death. Activity of this receptor has also been linked to carcinogenesis. Alternatively spliced transcript variants encoding multiple isoforms have been observed. [provided by RefSeq, Aug 2012]. Transcript (Including UTRs) Position: hg19 chr12:6,493,199-6,500,737 Size: 7,539 Total Exon Count: 10 Strand: + Coding Region Position: hg19 chr12:6,493,525-6,500,103 Size: 6,579 Coding Exon Count: 10
ID:TNR3_HUMAN DESCRIPTION: RecName: Full=Tumor necrosis factor receptor superfamily member 3; AltName: Full=Lymphotoxin-beta receptor; AltName: Full=Tumor necrosis factor C receptor; AltName: Full=Tumor necrosis factor receptor 2-related protein; AltName: Full=Tumor necrosis factor receptor type III; Short=TNF-RIII; Short=TNFR-III; Flags: Precursor; FUNCTION: Receptor for the heterotrimeric lymphotoxin containing LTA and LTB, and for TNFS14/LIGHT. Promotes apoptosis via TRAF3 and TRAF5. May play a role in the development of lymphoid organs. SUBUNIT: Self-associates. Associates with TRAF3, TRAF4 and TRAF5. Interacts with HCV core protein. INTERACTION: Self; NbExp=2; IntAct=EBI-3509981, EBI-3509981; Q15326:ZMYND11; NbExp=5; IntAct=EBI-3509981, EBI-2799565; SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein. SIMILARITY: Contains 4 TNFR-Cys repeats.
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Genetic Association Studies of Complex Diseases and Disorders
Genetic Association Database (archive): LTBR CDC HuGE Published Literature: LTBR Positive Disease Associations: Spondylitis, Ankylosing Related Studies:
Spondylitis, Ankylosing David M Evans et al. Nature genetics 2011, Interaction between ERAP1 and HLA-B27 in ankylosing spondylitis implicates peptide handling in the mechanism for HLA-B27 in disease susceptibility., Nature genetics.
[PubMed 21743469]
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P36941
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
L04489 - Homo sapiens (clone NCD18) tumor necrosis factor receptor related protein mRNA, complete exon and repeat region. AK293187 - Homo sapiens cDNA FLJ55950 complete cds, highly similar to Tumor necrosis factor receptor superfamily member 3 precursor. AK095418 - Homo sapiens cDNA FLJ38099 fis, clone D3OST1000238, highly similar to Tumor necrosis factor receptor superfamily member 3 precursor. BC026262 - Homo sapiens lymphotoxin beta receptor (TNFR superfamily, member 3), mRNA (cDNA clone MGC:22593 IMAGE:4703362), complete cds. AK027080 - Homo sapiens cDNA: FLJ23427 fis, clone HRC04788, highly similar to HUMTNFRRP Homo sapiens tumor necrosis factor receptor 2 related protein mRNA. L04270 - Homo sapiens (clone CD18) tumor necrosis factor receptor 2 related protein mRNA, complete cds. JD158149 - Sequence 139173 from Patent EP1572962. JD401118 - Sequence 382142 from Patent EP1572962. JD079745 - Sequence 60769 from Patent EP1572962. JD464995 - Sequence 446019 from Patent EP1572962. JD257138 - Sequence 238162 from Patent EP1572962. JD195365 - Sequence 176389 from Patent EP1572962. JD129331 - Sequence 110355 from Patent EP1572962. AB527559 - Synthetic construct DNA, clone: pF1KB6620, Homo sapiens LTBR gene for lymphotoxin beta receptor, without stop codon, in Flexi system. DQ891995 - Synthetic construct clone IMAGE:100004625; FLH182159.01X; RZPDo839D03138D lymphotoxin beta receptor (TNFR superfamily, member 3) (LTBR) gene, encodes complete protein. DQ895185 - Synthetic construct Homo sapiens clone IMAGE:100009645; FLH182156.01L; RZPDo839D03137D lymphotoxin beta receptor (TNFR superfamily, member 3) (LTBR) gene, encodes complete protein. CU693188 - Synthetic construct Homo sapiens gateway clone IMAGE:100022265 5' read LTBR mRNA. KJ897148 - Synthetic construct Homo sapiens clone ccsbBroadEn_06542 LTBR gene, encodes complete protein. AK128019 - Homo sapiens cDNA FLJ46138 fis, clone TESTI2052525, highly similar to Lymphotoxin-beta receptor precursor. BX648074 - Homo sapiens mRNA; cDNA DKFZp686M07210 (from clone DKFZp686M07210). JD345802 - Sequence 326826 from Patent EP1572962. JD372799 - Sequence 353823 from Patent EP1572962. JD418456 - Sequence 399480 from Patent EP1572962. JD365694 - Sequence 346718 from Patent EP1572962. JD218335 - Sequence 199359 from Patent EP1572962. JD176837 - Sequence 157861 from Patent EP1572962. JD500118 - Sequence 481142 from Patent EP1572962. JD226322 - Sequence 207346 from Patent EP1572962.
Biochemical and Signaling Pathways
KEGG - Kyoto Encyclopedia of Genes and Genomes hsa04060 - Cytokine-cytokine receptor interaction hsa04672 - Intestinal immune network for IgA production
Reactome (by CSHL, EBI, and GO)
Protein P36941 (Reactome details) participates in the following event(s):
R-HSA-5668789 LA,TNFSF14 binds LTBR R-HSA-5676591 2xLTBR binds LTBR:lymphotoxin,TNFSF14 trimer R-HSA-5676593 TRAF2:TRAF1:cIAP1,2:TRAF3:NIK regulatory complex binds LTBR R-HSA-5676594 TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway R-HSA-5668541 TNFR2 non-canonical NF-kB pathway R-HSA-1280215 Cytokine Signaling in Immune system R-HSA-168256 Immune System