ID:K1967_HUMAN DESCRIPTION: RecName: Full=DBIRD complex subunit KIAA1967; AltName: Full=Deleted in breast cancer gene 1 protein; Short=DBC-1; Short=DBC.1; AltName: Full=p30 DBC; FUNCTION: Core component of the DBIRD complex, a multiprotein complex that acts at the interface between core mRNP particles and RNA polymerase II (RNAPII) and integrates transcript elongation with the regulation of alternative splicing: the DBIRD complex affects local transcript elongation rates and alternative splicing of a large set of exons embedded in (A + T)-rich DNA regions. Inhibits SIRT1 deacetylase activity leading to increasing levels of p53/TP53 acetylation and p53-mediated apoptosis. Inhibits SUV39H1 methyltransferase activity. SUBUNIT: Component of the DBIRD complex. Interacts with ZNF326/ZIRD; the interaction is direct. Interacts (via N-terminus) with SIRT1. Interacts (via N-terminus) with SUV39H1; this interaction abolishes the interaction with SIRT1. INTERACTION: P01106:MYC; NbExp=8; IntAct=EBI-355410, EBI-447544; Q9Q2G4:ORF (xeno); NbExp=5; IntAct=EBI-355410, EBI-6248094; Q96EB6:SIRT1; NbExp=9; IntAct=EBI-355410, EBI-1802965; SUBCELLULAR LOCATION: Nucleus (Probable). TISSUE SPECIFICITY: Expressed ubiquitously in normal tissues. Expressed in 84 to 100% of neoplastic breast, lung, and colon tissues. SEQUENCE CAUTION: Sequence=AAG02472.1; Type=Frameshift; Positions=610, 622, 794, 810; Sequence=BAB85553.1; Type=Erroneous initiation;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q8N163
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0006351 transcription, DNA-templated GO:0006355 regulation of transcription, DNA-templated GO:0006397 mRNA processing GO:0006915 apoptotic process GO:0006974 cellular response to DNA damage stimulus GO:0007049 cell cycle GO:0008380 RNA splicing GO:0009411 response to UV GO:0016055 Wnt signaling pathway GO:0030308 negative regulation of cell growth GO:0031647 regulation of protein stability GO:0032435 negative regulation of proteasomal ubiquitin-dependent protein catabolic process GO:0032784 regulation of DNA-templated transcription, elongation GO:0042752 regulation of circadian rhythm GO:0043065 positive regulation of apoptotic process GO:0043086 negative regulation of catalytic activity GO:0043653 mitochondrial fragmentation involved in apoptotic process GO:0045892 negative regulation of transcription, DNA-templated GO:0048511 rhythmic process GO:0090263 positive regulation of canonical Wnt signaling pathway GO:0090311 regulation of protein deacetylation GO:1900034 regulation of cellular response to heat GO:1902230 negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage GO:2000003 positive regulation of DNA damage checkpoint
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