Human Gene SNX12 (uc004dyr.2)
  Description: Homo sapiens sorting nexin 12 (SNX12), transcript variant 2, mRNA.
RefSeq Summary (NM_013346): This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This protein does not contain a coiled coil region, like some family members. A similar protein in mouse may be involved in regulating the neurite outgrowth. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2012].
Transcript (Including UTRs)
   Position: hg19 chrX:70,279,097-70,288,298 Size: 9,202 Total Exon Count: 4 Strand: -
Coding Region
   Position: hg19 chrX:70,280,866-70,288,156 Size: 7,291 Coding Exon Count: 4 

Page IndexSequence and LinksPrimersCTDGene AllelesRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
Other NamesModel InformationMethods
Data last updated at UCSC: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chrX:70,279,097-70,288,298)mRNA (may differ from genome)Protein (162 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
GeneNetworkH-INVHGNCHPRDLynxMGI
OMIMPubMedUniProtKBBioGrid CRISPR DB

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 29.28 RPKM in Adrenal Gland
Total median expression: 1068.93 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -57.00142-0.401 Picture PostScript Text
3' UTR -630.271769-0.356 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR001683 - Phox

Pfam Domains:
PF00787 - PX domain

SCOP Domains:
64268 - PX domain

ModBase Predicted Comparative 3D Structure on Q3SYF1
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
      
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0035091 phosphatidylinositol binding


-  Descriptions from all associated GenBank mRNAs
  BC020559 - Homo sapiens sorting nexin 12, mRNA (cDNA clone IMAGE:3453724).
KJ902519 - Synthetic construct Homo sapiens clone ccsbBroadEn_11913 SNX12 gene, encodes complete protein.
BT007203 - Homo sapiens sorting nexin 12 mRNA, complete cds.
AK025781 - Homo sapiens cDNA: FLJ22128 fis, clone HEP19543.
BC108323 - Homo sapiens cDNA clone IMAGE:5000525.
BC063716 - Homo sapiens cDNA clone IMAGE:4998193, partial cds.
BC024301 - Homo sapiens, clone IMAGE:5429831, mRNA.
BC033809 - Homo sapiens, clone IMAGE:5183772, mRNA.
BC044059 - Homo sapiens, clone IMAGE:5211207, mRNA.
BC080535 - Homo sapiens cDNA clone IMAGE:4901571.
JD285307 - Sequence 266331 from Patent EP1572962.
JD154738 - Sequence 135762 from Patent EP1572962.
JD132454 - Sequence 113478 from Patent EP1572962.
BC103847 - Homo sapiens sorting nexin 12, mRNA (cDNA clone MGC:118982 IMAGE:40002749), complete cds.
BC103848 - Homo sapiens sorting nexin 12, mRNA (cDNA clone MGC:118983 IMAGE:40002752), complete cds.
AF171229 - Homo sapiens sorting nexin 12 (SNX12) mRNA, complete cds.
AK312977 - Homo sapiens cDNA, FLJ93438, Homo sapiens sorting nexin 12 (SNX12), mRNA.
KJ893716 - Synthetic construct Homo sapiens clone ccsbBroadEn_03110 SNX12 gene, encodes complete protein.

-  Other Names for This Gene
  Alternate Gene Symbols: hCG_1990496, NM_013346, NP_037478, Q3SYF1, Q3SYF1_HUMAN, uc004dyr.1
UCSC ID: uc004dyr.2
RefSeq Accession: NM_013346
Protein: Q3SYF1 CCDS: CCDS14405.1, CCDS59169.1

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: NM_013346.3
exon count: 4CDS single in 3' UTR: no RNA size: 2416
ORF size: 489CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 1178.00frame shift in genome: no % Coverage: 99.34
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 1907# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.