Description: Homo sapiens asialoglycoprotein receptor 2 (ASGR2), transcript variant H2', mRNA. RefSeq Summary (NM_080912): This gene encodes a subunit of the asialoglycoprotein receptor. This receptor is a transmembrane protein that plays a critical role in serum glycoprotein homeostasis by mediating the endocytosis and lysosomal degradation of glycoproteins with exposed terminal galactose or N-acetylgalactosamine residues. The asialoglycoprotein receptor may facilitate hepatic infection by multiple viruses including hepatitis B, and is also a target for liver-specific drug delivery. The asialoglycoprotein receptor is a hetero-oligomeric protein composed of major and minor subunits, which are encoded by different genes. The protein encoded by this gene is the less abundant minor subunit. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2011]. Transcript (Including UTRs) Position: hg19 chr17:7,004,641-7,018,130 Size: 13,490 Total Exon Count: 9 Strand: - Coding Region Position: hg19 chr17:7,004,894-7,017,559 Size: 12,666 Coding Exon Count: 8
ID:ASGR2_HUMAN DESCRIPTION: RecName: Full=Asialoglycoprotein receptor 2; Short=ASGP-R 2; Short=ASGPR 2; AltName: Full=C-type lectin domain family 4 member H2; AltName: Full=Hepatic lectin H2; Short=HL-2; FUNCTION: Mediates the endocytosis of plasma glycoproteins to which the terminal sialic acid residue on their complex carbohydrate moieties has been removed. The receptor recognizes terminal galactose and N-acetylgalactosamine units. After ligand binding to the receptor, the resulting complex is internalized and transported to a sorting organelle, where receptor and ligand are disassociated. The receptor then returns to the cell membrane surface. SUBUNIT: The functioning ligand-binding unit of this receptor is thought to be at least a dimer. Interacts with LASS2. INTERACTION: Q96G23:CERS2; NbExp=3; IntAct=EBI-1172636, EBI-1057080; SUBCELLULAR LOCATION: Membrane; Single-pass type II membrane protein. TISSUE SPECIFICITY: Expressed exclusively in hepatic parenchymal cells. MISCELLANEOUS: Calcium is required for ligand binding. SIMILARITY: Contains 1 C-type lectin domain. WEB RESOURCE: Name=Functional Glycomics Gateway - Glycan Binding; Note=Hepatic asialoglycoprotein receptor subunit 2; URL="http://www.functionalglycomics.org/glycomics/GBPServlet?&operationType=view&cbpId=cbp_hum_Ctlect_216";
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P07307
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0006897 endocytosis GO:0006898 receptor-mediated endocytosis GO:0007166 cell surface receptor signaling pathway GO:0009100 glycoprotein metabolic process GO:0018279 protein N-linked glycosylation via asparagine GO:0030282 bone mineralization GO:0031647 regulation of protein stability GO:0055088 lipid homeostasis
Cellular Component: GO:0005886 plasma membrane GO:0016020 membrane GO:0016021 integral component of membrane GO:0044322 endoplasmic reticulum quality control compartment GO:0048471 perinuclear region of cytoplasm
Descriptions from all associated GenBank mRNAs
M11025 - Human asialoglycoprotein receptor H2 mRNA, complete cds. LF384759 - JP 2014500723-A/192262: Polycomb-Associated Non-Coding RNAs. BC017251 - Homo sapiens asialoglycoprotein receptor 2, mRNA (cDNA clone MGC:29619 IMAGE:5087419), complete cds. X55284 - Human H2' mRNA coding for an asialoglycoprotein receptor. X55283 - Human L-H2 mRNA coding for an asialoglycoprotein receptor. JD509235 - Sequence 490259 from Patent EP1572962. JD038939 - Sequence 19963 from Patent EP1572962. JD278636 - Sequence 259660 from Patent EP1572962. JD303438 - Sequence 284462 from Patent EP1572962. JD359505 - Sequence 340529 from Patent EP1572962. AF529374 - Homo sapiens HBxAg-binding protein (HBXBP) mRNA, complete cds. U97197 - Homo sapiens asialoglycoprotein receptor (ASGPR) mRNA, complete cds. KJ890716 - Synthetic construct Homo sapiens clone ccsbBroadEn_00110 ASGR2 gene, encodes complete protein. DQ892652 - Synthetic construct clone IMAGE:100005282; FLH188670.01X; RZPDo839E1073D asialoglycoprotein receptor 2 (ASGR2) gene, encodes complete protein. DQ895891 - Synthetic construct Homo sapiens clone IMAGE:100010351; FLH188666.01L; RZPDo839E1063D asialoglycoprotein receptor 2 (ASGR2) gene, encodes complete protein. AB528625 - Synthetic construct DNA, clone: pF1KB6427, Homo sapiens ASGR2 gene for asialoglycoprotein receptor 2, without stop codon, in Flexi system. CU677885 - Synthetic construct Homo sapiens gateway clone IMAGE:100018074 5' read ASGR2 mRNA. LF326488 - JP 2014500723-A/133991: Polycomb-Associated Non-Coding RNAs. LF326487 - JP 2014500723-A/133990: Polycomb-Associated Non-Coding RNAs. AK310123 - Homo sapiens cDNA, FLJ17165. AK303787 - Homo sapiens cDNA FLJ60040 complete cds, highly similar to Homo sapiens asialoglycoprotein receptor 2 (ASGR2), transcript variant 2, mRNA. JD337957 - Sequence 318981 from Patent EP1572962. JD371454 - Sequence 352478 from Patent EP1572962. JD387367 - Sequence 368391 from Patent EP1572962. JD306763 - Sequence 287787 from Patent EP1572962. JD100134 - Sequence 81158 from Patent EP1572962. JD525965 - Sequence 506989 from Patent EP1572962. JD495969 - Sequence 476993 from Patent EP1572962. JD150580 - Sequence 131604 from Patent EP1572962. JD149016 - Sequence 130040 from Patent EP1572962. JD335895 - Sequence 316919 from Patent EP1572962. MA620336 - JP 2018138019-A/192262: Polycomb-Associated Non-Coding RNAs. MA562065 - JP 2018138019-A/133991: Polycomb-Associated Non-Coding RNAs. MA562064 - JP 2018138019-A/133990: Polycomb-Associated Non-Coding RNAs.
Biochemical and Signaling Pathways
Reactome (by CSHL, EBI, and GO)
Protein P07307 (Reactome details) participates in the following event(s):
R-HSA-8855711 PALM-C36-ASGR1:PALM-C54,58-ASGR2 binds desialated glycoproteins R-HSA-446203 Asparagine N-linked glycosylation R-HSA-597592 Post-translational protein modification R-HSA-392499 Metabolism of proteins
US Server
