Description: Homo sapiens kinase non-catalytic C-lobe domain (KIND) containing 1 (KNDC1), mRNA. RefSeq Summary (NM_152643): The protein encoded by this gene is a Ras guanine nucleotide exchange factor that appears to negatively regulate dendritic growth in the brain. Knockdown of this gene in senescent umbilical vein endothelial cells partially reversed the senescence, showing that this gene could potentially be targeted by anti-aging therapies. [provided by RefSeq, Dec 2016]. Transcript (Including UTRs) Position: hg19 chr10:134,973,971-135,039,916 Size: 65,946 Total Exon Count: 30 Strand: + Coding Region Position: hg19 chr10:134,973,972-135,038,394 Size: 64,423 Coding Exon Count: 30
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q76NI1
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0001934 positive regulation of protein phosphorylation GO:0007264 small GTPase mediated signal transduction GO:0008150 biological_process GO:0021707 cerebellar granule cell differentiation GO:0048814 regulation of dendrite morphogenesis GO:0050773 regulation of dendrite development