Human Gene EXOC3L4 (uc001ymk.3)
  Description: Homo sapiens exocyst complex component 3-like 4 (EXOC3L4), mRNA.
Transcript (Including UTRs)
   Position: hg19 chr14:103,566,481-103,576,894 Size: 10,414 Total Exon Count: 11 Strand: +
Coding Region
   Position: hg19 chr14:103,566,557-103,576,560 Size: 10,004 Coding Exon Count: 11 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr14:103,566,481-103,576,894)mRNA (may differ from genome)Protein (722 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
GeneNetworkH-INVHGNCHPRDLynxMGI
neXtProtPubMedTreefamUniProtKBBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: EX3L4_HUMAN
DESCRIPTION: RecName: Full=Exocyst complex component 3-like protein 4;
SIMILARITY: Belongs to the SEC6 family.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 25.29 RPKM in Liver
Total median expression: 61.75 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -17.6076-0.232 Picture PostScript Text
3' UTR -149.80334-0.449 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR010326 - Sec6

Pfam Domains:
PF06046 - Exocyst complex component Sec6

ModBase Predicted Comparative 3D Structure on Q17RC7
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologGenome BrowserGenome BrowserNo orthologNo orthologNo ortholog
 Gene Details    
 Gene Sorter    
 RGDEnsembl   
 Protein SequenceProtein Sequence   
 AlignmentAlignment   

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0000149 SNARE binding

Biological Process:
GO:0006887 exocytosis
GO:0051601 exocyst localization

Cellular Component:
GO:0000145 exocyst


-  Descriptions from all associated GenBank mRNAs
  BC113655 - Homo sapiens chromosome 14 open reading frame 73, mRNA (cDNA clone MGC:142215 IMAGE:8322707), complete cds.
BC117375 - Homo sapiens chromosome 14 open reading frame 73, mRNA (cDNA clone MGC:150984 IMAGE:40125926), complete cds.
HQ258590 - Synthetic construct Homo sapiens clone IMAGE:100073125 chromosome 14 open reading frame 73 (C14orf73) gene, encodes complete protein.
KJ905590 - Synthetic construct Homo sapiens clone ccsbBroadEn_15216 EXOC3L4 gene, encodes complete protein.
KJ906394 - Synthetic construct Homo sapiens clone ccsbBroadEn_16064 EXOC3L4 gene, encodes complete protein.
AK000671 - Homo sapiens cDNA FLJ20664 fis, clone KAIA795.
JD391585 - Sequence 372609 from Patent EP1572962.
JD461632 - Sequence 442656 from Patent EP1572962.
JD370138 - Sequence 351162 from Patent EP1572962.
JD368025 - Sequence 349049 from Patent EP1572962.
JD060639 - Sequence 41663 from Patent EP1572962.
JD481010 - Sequence 462034 from Patent EP1572962.
JD478381 - Sequence 459405 from Patent EP1572962.
JD140043 - Sequence 121067 from Patent EP1572962.
JD164396 - Sequence 145420 from Patent EP1572962.
JD163285 - Sequence 144309 from Patent EP1572962.
JD471779 - Sequence 452803 from Patent EP1572962.
JD124738 - Sequence 105762 from Patent EP1572962.
JD095463 - Sequence 76487 from Patent EP1572962.
JD147478 - Sequence 128502 from Patent EP1572962.
JD518673 - Sequence 499697 from Patent EP1572962.
JD275219 - Sequence 256243 from Patent EP1572962.
JD108454 - Sequence 89478 from Patent EP1572962.
JD545740 - Sequence 526764 from Patent EP1572962.
JD492805 - Sequence 473829 from Patent EP1572962.
JD376196 - Sequence 357220 from Patent EP1572962.
JD347208 - Sequence 328232 from Patent EP1572962.
JD334746 - Sequence 315770 from Patent EP1572962.
JD186981 - Sequence 168005 from Patent EP1572962.
JD065270 - Sequence 46294 from Patent EP1572962.
JD246287 - Sequence 227311 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: C14orf73, EX3L4_HUMAN, NM_001077594, NP_001071062, Q14CR2, Q17RC7
UCSC ID: uc001ymk.3
RefSeq Accession: NM_001077594
Protein: Q17RC7 (aka EX3L4_HUMAN)
CCDS: CCDS32163.1

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: NM_001077594.1
exon count: 11CDS single in 3' UTR: no RNA size: 2591
ORF size: 2169CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 4305.00frame shift in genome: no % Coverage: 99.54
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.