ID:SHOT1_HUMAN DESCRIPTION: RecName: Full=Shootin-1; FUNCTION: Involved in the generation of internal asymmetric signals required for neuronal polarization. Acts upstream of PI3K (phosphoinositide 3-kinase), by being required for spatially localized PI3K activity. Accumulates asymmetrically in a single neurite before polarization, leading to axon induction for polarization, its absence from the nascent axon's siblings by competition preventing the formation of surplus axons (By similarity). SUBUNIT: Interacts with RUFY3 (By similarity). SUBCELLULAR LOCATION: Cell projection, axon (By similarity). SIMILARITY: Belongs to the shootin family. SEQUENCE CAUTION: Sequence=AAH22348.1; Type=Erroneous initiation; Sequence=BAA92019.1; Type=Erroneous initiation; Sequence=BAG53052.1; Type=Erroneous initiation; Sequence=BAG53110.1; Type=Erroneous initiation;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on A0MZ66
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
