Human Gene GRM5 (uc001pcq.3) Description and Page Index
Description: Homo sapiens glutamate receptor, metabotropic 5 (GRM5), transcript variant a, mRNA. RefSeq Summary (NM_001143831): This gene encodes a member of the G-protein coupled receptor 3 protein family. The encoded protein is a metabatropic glutamate receptor, whose signaling activates a phosphatidylinositol-calcium second messenger system. This protein may be involved in the regulation of neural network activity and synaptic plasticity. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. A pseudogene of this gene has been defined on chromosome 11. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]. Transcript (Including UTRs) Position: hg19 chr11:88,237,744-88,781,240 Size: 543,497 Total Exon Count: 9 Strand: - Coding Region Position: hg19 chr11:88,241,760-88,781,040 Size: 539,281 Coding Exon Count: 9
ID:GRM5_HUMAN DESCRIPTION: RecName: Full=Metabotropic glutamate receptor 5; Short=mGluR5; Flags: Precursor; FUNCTION: Receptor for glutamate. The activity of this receptor is mediated by a G-protein that activates a phosphatidylinositol- calcium second messenger system and generates a calcium-activated chloride current. SUBUNIT: The PPXXF motif binds HOMER1, HOMER2 and HOMER3. Interacts with SIAH1, RYR1, RYR2, ITPR1, SHANK1, SHANK3 and GRASP. Interacts with NCDN (By similarity). SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. SIMILARITY: Belongs to the G-protein coupled receptor 3 family.
Genetic Association Studies of Complex Diseases and Disorders
Alcohol dependence Bierut ,et al. Proc Natl Acad Sci USA 2010, A genome-wide association study of alcohol dependence , Proceedings of the National Academy of Sciences of the United States of America 2010 107- 11 : 5082-7.
Attention Deficit Disorder with Hyperactivity Anke Hinney et al. American journal of medical genetics. Part B, Neuropsychiatric genetics 2011, Genome-wide association study in German patients with attention deficit/hyperactivity disorder., American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetic.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF00003 - 7 transmembrane sweet-taste receptor of 3 GCPR PF01094 - Receptor family ligand binding region PF07562 - Nine Cysteines Domain of family 3 GPCR PF10606 - Homer-binding domain of metabotropic glutamate receptor
ModBase Predicted Comparative 3D Structure on P41594
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.